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68Ga-PSMA-11 uptake in tracheal mucus plug – a potential pitfall
Kunal Ramesh Chandekar,Apurva Sood,Kumar Rajender,Singh Harmandeep,Shrawan Kumar Singh 대한핵의학회 2022 핵의학 분자영상 Vol.56 No.1
Prostate-specific membrane antigen (PSMA) PET/CT is a well-acclaimed imaging modality for prostate cancer (PCa). However, many reports have highlighted PSMA radioligand uptake in a variety of benign tumors and lesions. We report a case of PCa in which 68 Ga-PSMA-11 uptake was noted in the tracheal lumen. However, 18F-PSMA-1007 PET/CT was done on a subsequent day, which demonstrated no abnormal radiotracer uptake or morphological lesion within the tracheal lumen. This case highlights an uncommon finding of PSMA ligand uptake in a tracheal mucus plug (non-prostatic benign uptake), which may be misinterpreted as a false-positive finding.
Kunal Ramesh Chandekar,Sindhu Tanigassalam,Anwin Joseph Kavanal,Singh Harmandeep,Anish Bhattacharya,Ravimohan Suryanarayan Mavuduru 대한핵의학회 2022 핵의학 분자영상 Vol.56 No.2
The rapidly evolving clinical utility of prostate-specific membrane antigen (PSMA) PET/CT as an imaging modality for prostate cancer (PCa) has brought to the forefront a multitude of non-prostatic diseases also exhibiting PSMA radioligand uptake. We report a case of a 71-year-old male with PCa who underwent PSMA PET/CT for recurrence evaluation. The scan demonstrated [68 Ga]Ga-PSMA-11 uptake in the distal ileum. Retrospective enquiry revealed that the patient was a known case of Crohn’s disease. This case highlights an uncommon finding of PSMA radioligand uptake in the distal small bowel (non-prostatic benign pathological uptake) in a patient with known Crohn’s disease, which may be misinterpreted in the evaluation of PCa.
Perirenal Fascia — an Uncommon Site of Metastases in Prostate Cancer Detected on 68Ga-PSMA-11 PET/CT
Kunal Ramesh Chandekar 대한핵의학회 2023 핵의학 분자영상 Vol.57 No.5
Prostate-specific membrane antigen (PSMA) PET/CT is being increasingly utilized as a hybrid imaging modality for the evaluationof prostate cancer (PCa). We report a case of a 50-year-old man with biopsy-proven high-risk PCa in which multipletracer avid perirenal fascia deposits were identified on 68Ga-PSMA-11 PET/CT, in addition to multi-focal prostatic primary,extensive nodal, and skeletal metastases. This case highlights that perirenal fascia is an uncommon metastatic site in PCa.
Incidental Muscle Uptake of 177 Lu-DOTATATE in Peripheral Vascular Disease
Piyush Aggarwal,Kunal Ramesh Chandekar,Ashwani Sood,Shakti Zerial,Rajender Kumar,Anindita Sinha 대한핵의학회 2021 핵의학 분자영상 Vol.55 No.6
Somatostatin receptor (SSTR)-based imaging and therapy has emerged as well-established modality in neuroendocrinetumors. However, its role in inflammation imaging is still evolving. We present a 48-year-old male with metastatic neuroendocrinetumor who underwent lutetium-177-based somatostatin receptor-based therapy. The post-therapy scan showed afocal tracer uptake in the left calf muscle in addition to the expected tracer uptake at the primary and metastatic sites. Further,cross-sectional imaging and biochemical investigations revealed peripheral vascular disease (PVD). The incidental traceruptake in the calf on post-therapy scan potentiates the role of somatostatin receptor scintigraphy in identifying macrophagespecificinflammatory reactions.