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Molecular perspective of iron uptake, related diseases, and treatments
Negin Shokrgozar,Habib Allah Golafshan 대한혈액학회 2019 Blood Research Vol.54 No.1
Iron deficiency anemia and anemia of chronic disorders are the most common types of anemia. Disorders of iron metabolism lead to different clinical scenarios such as iron defi-ciency anemia, iron overload, iron overload with cataract and neurocognitive disorders. Regulation of iron in the body is a complex process and different regulatory proteins are involved in iron absorption and release from macrophages into hematopoietic tissues. Mutation in these regulatory genes is the most important cause of iron refractory iron deficiency anemia (IRIDA). This review provides a glance into the iron regulation process, diseases related to iron metabolism, and appropriate treatments at the molecular level.
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Molecular perspective of iron uptake, related diseases, and treatments
Negin Shokrgozar,Habib Allah Golafshan 대한혈액학회 2019 Blood Research Vol.54 No.1
Iron deficiency anemia and anemia of chronic disorders are the most common types of anemia. Disorders of iron metabolism lead to different clinical scenarios such as iron defi-ciency anemia, iron overload, iron overload with cataract and neurocognitive disorders. Regulation of iron in the body is a complex process and different regulatory proteins are involved in iron absorption and release from macrophages into hematopoietic tissues. Mutation in these regulatory genes is the most important cause of iron refractory iron deficiency anemia (IRIDA). This review provides a glance into the iron regulation process, diseases related to iron metabolism, and appropriate treatments at the molecular level.
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Asgarian, Behrouz,Shokrgozar, Hamed Rahman,Shahcheraghi, Davoud,Ghasemzadeh, Hasan Techno-Press 2012 Coupled systems mechanics Vol.1 No.4
Dynamic response of Pile Supported Structures is highly depended on Soil Pile Structure Interaction. In this paper, by comparison of experimental and numerical dynamic responses of a prototype jacket offshore platform for both hinge based and pile supported boundary conditions, effect of soil-pile-structure interaction on dynamic characteristics of this platform is studied. Jacket and deck of a prototype platform is installed on a hinge-based case first and then platform is installed on eight skirt piles embedded on continuum monolayer sand. Dynamic characteristics of platform in term of natural frequencies, mode shapes and modal damping are compared for both cases. Effects of adding and removing vertical bracing members in top bay of jacket on dynamic characteristics of platform for both boundary conditions are also studied. Numerical simulation of responses for the studied platform is also performed for both mentioned cases using capability of ABAQUS and SACS software. The 3D model using ABAQUS software is created using solid elements for soil and beam elements for jacket, deck and pile members. Mohr-Coulomb failure criterion and pile-soil interface element are used for considering nonlinear pile soil structure interaction. Simplified modeling of soil-pile-structure interaction effect is also studied using SACS software. It is observed that dynamic characteristics of the system changes significantly due to soil-pile-structure interaction. Meanwhile, both of complex and simplified (ABAQUS and SACS, respectively) models can predict this effect accurately for such platforms subjected to dynamic loading in small range of deformation.
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Zeinali Heris Saeed,Pourfarhang Samira,Shokrgozar Motahare,Kahani Mostafa 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.4
We investigated the role of nanofluid in a special car radiator and the effect of its different volume concentrationson pressure drop and friction factor of fluid flow. A mixture of 60/40 ratio of ethylene glycol (EG) and distilledwater was used as the host fluid and CuO nanoparticles were dispersed well to make stable nanofluids. The influenceof nanofluid concentrations on pressure drop was evaluated in the radiator at three different inlet fluid temperatures(35, 44, 54 oC). The results demonstrated that the presence of nanoparticles caused an increase in nanofluid pressuredrop, which was intensified by increasing nanoparticle concentration as well as decreasing temperature of inlet fluid. Anew empirical equation for prediction of nanofluid pressure drop through the radiator was developed as well. Also,with increasing the flow rate, the performance index increased and indicated that application of nanofluid in higherflow rate was affordable.
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Mohsen Rabbani,Mohammad Tafazzoli-Shadpour,Mohammad Ali Shokrgozar,Mohsen Janmaleki,Morteza Teymoori 한국조직공학과 재생의학회 2017 조직공학과 재생의학 Vol.14 No.3
Recent investigations consider adipose-derived stemcells (ASCs) as a promising source of stemcells for clinical therapies. To obtain functional cells with enhanced cytoskeleton and aligned structure, mechanical stimuli are utilized during differentiation of stem cells to the target cells. Since function of muscle cells is associated with cytoskeleton, enhanced structure is especially essential for these cells when employed in tissue engineering. In this study by utilizing a custom-made device, effects of uniaxial tension (1Hz, 10% stretch) on cytoskeleton, cell alignment, cell elastic properties, and expression of smooth muscle cell (SMC) genes in ASCs are investigated.Due to proper availability ofASCs, results can be employed in cardiovascular engineeringwhen production of functional SMCs in arterial reconstruction is required. Results demonstrated that cells were oriented after 24 hours of cyclic stretch with aligned pseudo-podia. Staining of actin filaments confirmed enhanced polymerization and alignment of stress fibers. Such phenomenon resulted in stiffening of cell body which was quantified by atomic force microscopy (AFM). Expression of SM a-actin and SM22 aactin as SMC associated genes were increased after cyclic stretch while GAPDH was considered as internal control gene. Finally, it was concluded that application of cyclic stretch on ASCs assists differentiation to SMC and enhances functionality of cells.
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M. Taherian,A.A. Sabbagh Alvani,M. A. Shokrgozar,R. Salimi,S. Moosakhani,H. Sameie,F. Tabatabaee 대한금속·재료학회 2014 ELECTRONIC MATERIALS LETTERS Vol.10 No.2
In the present study, the ZnS semiconductor quantum dots were successfully synthesized via an aqueous method utilizing glutathione (GSH), thioglycolic acid (TGA) and polyvinyl pyrrolidone (PVP) as capping agents. The structural, morphological and photo-physical properties and biocompatibility were investigated using comprehensive characterization techniques such as x-ray diffraction (XRD), scanning and transmission electron microscopy (SEM and TEM), dynamic light scattering (DLS), Fourier transform infrared spectrometry (FT-IR), UVVis optical absorption, photoluminescence (PL) spectrometer and MTT assay. The XRD patterns showed a cubic zinc blende crystal structure and a crystallite size of about 2 - 3 nm using Scherrer’s equation confirmed by the electron micrographs and Effective Mass Approximation (EMA). The DLS and zeta-potential results revealed that GSH capped ZnS nanoparticles have the narrowest size distribution with an average size of 27 nm and relatively good colloidal stability. Also, the FT-IR spectrum confirmed the interaction of the capping agent groups with ZnS nanoparticles. According to the UV-Vis absorption results, optical bandgap of the spherical capped nanoparticles is higher compared to the uncapped sample and could be wider than 3.67 eV (corresponding to the bulk ZnS), which is due to the quantum confinement effect. From photoluminescence spectra, it was found that the emission becomes more intensive and shifts towards the shorter wavelengths in the presence of the capping agent. Moreover, the emission mechanism of uncapped and capped ZnS was discussed in detail. Finally, the MTT results revealed the satisfactory (>94%) biocompatibility of GSH capped ZnS quantum dots which would be a promising candidate applicable in fluorescent biological labels.
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Alireza Hadizadeh Tasbiti,Shamsi Yari,Mostafa Ghanei,Mohammad Ali Shokrgozar,Abolfazl Fateh,Ahmadreza Bahrmand 질병관리본부 2017 Osong Public Health and Research Persptectives Vol.8 No.2
Objectives: Extensively drug-resistant tuberculosis (XDR-TB) is more expensive and difficult to treat than multidrug-resistant tuberculosis (MDR-TB), and outcomes for patients are much worse; therefore, it is important that clinicians understand the magnitude and distribution of XDR-TB. We conducted a retrospective study to compare the estimated incidence of and risk factors for M/XDR-TB with those of susceptible TB controls. Methods: Sputum culture and drug susceptibility testing (DST) were performed in patients with known or suspected TB. Strains that were identified as MDR were subjected to DST for secondline drugs using the proportion method. Results: Among 1,442 TB patients (mean age, 46.48 ± 21.24 years) who were culture-positive for Mycobacterium tuberculosis, 1,126 (78.1%) yielded isolates that were resistant to at least one first-line drug; there were 33 isolates (2.3%) of MDR-TB, of which three (0.2%) were classified as XDR-TB. Ofloxacin resistance was found in 10 (0.7%) isolates. Women were 15% more likely than men to yield M/XDR-TB isolates, but this difference was not significant. In a multivariate analysis comparing susceptible TB with X/MDR-TB, only one variable—the number of previous treatment regimens—was associated with MDR (odds ratio, 1.06; 95% confidence interval, 1.14–21.2). Conclusion: The burden of M/XDR-TB cases is not sizeable in Iran. Nonetheless, strategies must be implemented to identify and cure patients with pre-XDR-TB before they develop XDR-TB. Our results provide a greater understanding of the evolution and spread of M/XDR-TB in an environment where drug-resistant TB has a low incidence.
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Omid Reza Zekavat,Yasaman Movahednezhad,Amin Shahsavani,Sezaneh Haghpanah,Negin Shokrgozar,Hossein Golmoghaddam,Mehdi Kalani,Mohammad Reza Bordbar,Nargess Arandi 대한혈액학회 2024 Blood Research Vol.59 No.2
Background Development of antibodies against infused Factor VIII (FVIII) or "inhibitors" represents a major challenge following FVIII replacement therapy in patients with hemophilia A (HA). Recent studies have shown that certain cellular compartments of the immune system contribute to the production of such antibodies. Herein, we determined the frequency of class-switched CD19+ IgD−CD27+/non-class-switched CD19+ IgD+CD27+ memory B cell subsets and CD19+ CD27hiCD38hi plasmablasts in patients with severe HA and their association with the development of inhibitors in these patients. Methods This cross-sectional case–control study enrolled 32 patients with severe HA, including 8 with and 24 without inhibitors, and 24 healthy individuals. The frequencies of the memory B cell subsets and plasmablasts were determined using flow cytometry. Results The frequency of CD19+ IgD+CD27+ non-class-switched memory B cells was significantly lower in patients with HA (including both patients with and without inhibitors) than in healthy controls. The percentages of both CD19+ IgD−CD27+ class-switched and CD19+ IgD+CD27+ non-class-switched memory B cells did not differ significantly between patients with and without inhibitors. HA patients with inhibitors had significantly higher proportions of CD19+ CD27hiCD38hi plasmablasts than the control group as well as the inhibitor (-) ones. No significant correlation was observed between the inhibitor levels with the percentages of memory B cell subsets and plasmablasts. Conclusion This study is the first to demonstrate a dysregulated proportion of CD19+ IgD+CD27+ non-class-switched memory B cells and CD19+ CD27hiCD38hi plasmablasts in patients with severe HA. Therefore, strategies targeting memory B-cell/plasmablast differentiation may have promising outcomes in the management of inhibitor formation in patients with severe HA.
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