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Water-Soluble Undenatured Type II Collagen Ameliorates Collagen-Induced Arthritis in Mice
Orie Yoshinari,Yoshiaki Shiojima,Hiroyoshi Moriyama,Junichi Shinozaki,Takahisa Nakane,Kazuo Masuda,Manashi Bagchi 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.11
Earlier studies have reported the efficacy of type II collagen (C II) in treating rheumatoid arthritis (RA). However, a few studies have investigated the ability of the antigenic collagen to induce oral tolerance, which is defined as active nonresponse to an orally administered antigen. We hypothesized that water-soluble undenatured C II had a similar effect as C II in RA. The present study was designed to examine the oral administration of a novel, water-soluble, undenatured C II (commercially known as NEXT-II) on collagen-induced arthritis (CIA) in mice. In addition, the underlying mechanism of NEXT-II was also identified. After a booster dose (collagen-Freund’s complete adjuvant), mice were assigned to control CIA group, or NEXT-II treatment group, to which saline and NEXT-II were administered, respectively. The arthritis index in the NEXT-II group was significantly lower compared with the CIA group. Serum IL-6 levels in the NEXT-II group were significantly lower compared with the CIA group, while serum IL-2 level was higher. Furthermore, oral administration of NEXT-II enhanced the proportion of CD4 + CD25 + T (Treg) cells, and gene expressions of stimulated dendritic cells induced markers for regulatory T cells such as forkhead box p3 (Foxp3), transforming growth factor (TGF)-b1, and CD25. These results demonstrated that orally administered water-soluble undenatured C II (NEXT-II) is highly efficacious in the suppression of CIA by inducing CD4 + CD25 + Treg cells.
Shimizu, Ippei,Minamino, Tohru,Toko, Haruhiro,Okada, Sho,Ikeda, Hiroyuki,Yasuda, Noritaka,Tateno, Kaoru,Moriya, Junji,Yokoyama, Masataka,Nojima, Aika,Koh, Gou Young,Akazawa, Hiroshi,Shiojima, Ichiro,K American Society for Clinical Investigation 2010 The Journal of clinical investigation Vol.120 No.5