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      • 絨毛性고나도트로핀의 放射免疫測定에 關한 硏究

        申冕雨 中央醫學社 1974 中央醫學 Vol.27 No.2

        It is not practical to quantitate HCG in the serum of normal pregnant women by utilizing hemagglutination inhibition technique and bioassay. For the practical application of radioimmunoassay and technical familiarization, quantitative determination of HCG were performed by means of radioimmunoassay-Antisera were developed against human chorionic gonadotropin. Highly purified HCG was radioiodinated with Na-125I by the method of Greenwood, Hunter and Glover and labeled HCG was separated by Sephadex G-100 column chromatography. Separation cf antibody-bound from 'free HCG-125I was accomplished by a double antibody technique and the obtained results are as following. 1) The sensitivity of radioimmunoassay in this study could detect 10 mIU/ml of. HCG. 2) The quantitative determination of HCG in the serum of 137 pregnant women at various gestational period revealed that HCG has been sharply increased after 5th week of gestation and reached to the peak in 9-12th week, giving an average of 106, 000 IU/L, then gradually declined to reach a point of minimum-levels in 20th week and 20, 000-30, 000 IU/L has been maintained until the end of pregnancy. 3) Comparison between HCG levels in serum of pregnant women at various gestational period and that of urine determined by HAIR revealed very similar changing pattern.

      • 會陰裂傷 및 會陰切開患者에 있어서 Chymoral의 臨床的 觀察

        申冕雨,李珍鏞,金基宗,朴貞範 中央醫學社 1972 中央醫學 Vol.22 No.3

        Chymotrypsin is an endopeptidase, fractionated from bovine pancreas, by modification of the Kunitz and Northrop method. Innerfield observed that intravenously administered trypsin induced lytic effect on artificially formed intravascular thrombi in animal experiments. More recent data suggest that chymotrypsin(parenteral or buccal) may be successfully used to prevent tie pain, edema and ecchymosis of episiotomy wounds. Preliminary studies of several authors indicate that chymoral has clinical effectiveness exactly parallel of that obtainable with the parenteral and buccal forms of chymotrypsin. This proteolytic enzymes are increasing interest and have been widely employed clinically as anti-inflammatory and antiedemic remedies. The double-blind study was carried out in 100 obstetric patients to determine clinical effectiveness of chymoral to aid in relieving edema, pain and ecchymosis following perineal laceration or episiotomy. The result of the study are as follows. 1. Chymoral proved to be an effective drug in reducing edema during the 3 postpartum days when it is most marked. 2. Pain. and ecchymosis were also considerably reduced in treated group. 3. There was no complete absence of side effects which could be ascribed to the drug.

      • 經口避姙劑 服用婦人의 尿 및 血淸中 黃體化홀몬(Luteinizing Hormone)의 動態에 關한 免疫學的 硏究

        信熙澈,申冕雨 中央醫學社 1974 中央醫學 Vol.27 No.6

        Blood serum and urine levels of luteinizing hormone (L.H.) in oral contraceptive (Ovulen; ethynodiol diacetate 1mg-; mestranol 100 mcg) users were measured using hemagglutination inhibition reaction based upon the cross reaction between the HCG-antiserum to L.H. Following results were obtained; 1) Human Chorionic Gonadotropin (H.C.G.) of relatively high purity (5000 IU/ mg) have been used as antigen for the immunization of rabbits and high titer of antiserum was obtained through the effects of Freund's adjuvant and booster injections. 2) Gel diffusion method of Ouchterlony revealed only one clear precipitation line between the H.C.G. and its antiserum, indicating that the used antigen was relatively pure and the antisera contained negligible amount of nonspecific antibody. 3) The sensitivity of hemagglutination reaction in this study was about 50 IU/L. 4) One volume of urine or blood serum was treated with four volumes of ace-tone and L.H. containing fraction was washed with one volume of absolute alcohol and ether, then dissolved in 1/10 volume of pH 6. 4 phosphate buffered saline, thus concentrating the original specimen 10 times. 5) Three out of seven healthy parous women selected in this study started Ovulen from 5th MCD (menstrual cycle day). 6) Early morning samples of the urine and blood serum were collected from 10 th MCD showed no L.H. peak after Ovulen administration.

      • 대학의 지속가능경영 전략 수립을 위한 제언

        이영면 ( Young Myon Lee ),박준우 ( Jun Woo Park ),신태중 ( Tae Jung Shin ) 한국윤리경영학회(구 한국기업윤리학회) 2015 윤리경영연구 Vol.15 No.2

        대학은 교육과 연구를 통해 우리사회의 지속가능성에 크게 영향을 미치는 조직이며, 지속가능한 사회를 위해 중요한 역할을 할 것으로 기대된다. 해외의 많은 대학들은1990년대부터 지속가능한 발전을 위한 대학의 책임을 인식하고 이의 실천을 위한 선언에 동참하고 있다. 그러나 대학의 지속가능경영에 관한 연구는 거의 이루어지지 않았다. 본 연구는 대학 지속가능경영에 관한 이론적 연구의 기반을 마련하기 위한 탐색적 연구로, 지속가능경영을 실천하는 해외 대학들을 대상으로 사례조사를 실시하였다. 본격적조사에 앞서 지속가능경영에 관한 국제적 원칙들과 대학 지속가능경영에 관한 규범적논의들을 검토하였다. 이어 미국, 영국, 일본의 주요 대학들의 사례 연구를 통해 대학 지속가능경영의 주요 요소와 이슈들을 파악하였다. 또한 지속가능경영을 실천하고자 하는 대학들에게 고려해야 할 실무적 시사점을 제공하였다. 마지막으로 연구의 한계를 지적하고 향후 연구 방향을 논의하였다. University has significant effects on the sustainability of our society through its education and research activities. It is expected that university should play an important role of building sustainable society. Many overseas universities have understood their responsibilities for sustainable development and implement sustainable practices. However, research on sustainable management was difficult to find. Current research is an exploratory research laying the basis for theoretical research on university sustainability. We revised international principles of sustainability and normative discourse on the university sustainability. We also studied some cases of US, UK and Japan universities and found important factors and issues in university sustainability. Our finding provides the managerial implications with university managers. Finally, some limitations of current research and directions for future research were discussed.

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