Methemoglobinemia caused by a low dose of prilocaine during general anesthesia

Shibuya, Makiko,Hojo, Takayuki,Hase, Yuri,Kimura, Yukifumi,Fujisawa, Toshiaki The Korean Dental Society of Anesthsiology 2021 Journal of Dental Anesthesia and Pain Medicine Vol.21 No.4

Methemoglobinemia is a blood disorder in which an abnormal amount of methemoglobin is produced, and prilocaine is one of the drugs that can cause this disorder. The maximum recommended dose of prilocaine is 8 mg/kg. We report a case of methemoglobinemia caused by the administration of 4.2 mg/kg of prilocaine without other methemoglobinemia-inducing drugs during general anesthesia. A 17-year-old girl with hyperthyroidism and anemia was scheduled to undergo maxillary sinus floor elevation and tooth extraction. The patient's peripheral oxygen saturation (SpO₂) decreased from 100% at arrival to 95% after receiving prilocaine with felypressin following induction of general anesthesia. However, the fraction of inspired oxygen was 0.6. Blood gas analysis showed that the methemoglobin level was 3.8% (normal level, 1%-2%), fractional oxygen saturation was 93.9%, partial pressure of oxygen was 327 mmHg, and arterial oxygen saturation was 97.6%. After administration of 1 mg/kg of methylene blue, her SpO₂ improved gradually to 99%, and the methemoglobin value decreased to 1.2%. When using prilocaine as a local anesthetic, it is important to be aware that methemoglobinemia may occur even at doses much lower than the maximum recommended dose.

Involvement of Vascular Endothelial Growth Factor(VEGF) and its Receptors(Flt-1 and KDR/Flk-1) in Angiogenesis and Ascites Formati

Shibuya, Masabumi 가톨릭 의과학연구원 1999 가톨릭 의과학연구원 국제학술대회 Vol.3 No.-

Differential Roles of Vascular Endothelial Growth Factor Receptor-1 and Receptor-2 in Angiogenesis(Review)

Shibuya, Masabumi 한국생화학분자생물학회 (구 한국생화학회) 2006 BMB Reports Vol.39 No.5

Earwax of patients with hidradenitis suppurativa: A retrospective study

Shibuya, Yuka,Morioka, Daichi,Nomura, Misako,Zhang, Zhuo,Utsunomiya, Hiroki Korean Society of Plastic and Reconstructive Surge 2019 Archives of Plastic Surgery Vol.46 No.6

Background In Western nations, hidradenitis suppurativa (HS) typically affects the apocrine gland-bearing skin of people of African origin, women, smokers, and individuals with obesity. The clinical characteristics of HS in Korea and Japan, however, are reportedly different from those in the West. We therefore hypothesized that wet earwax is associated with HS because most East Asian people are genetically predisposed to produce dry earwax. Methods The medical charts of 53 Japanese patients with HS were reviewed retrospectively. Results Unlike the results of surveys conducted in Western nations, most of our patients were men (72%), whose buttocks were the most commonly affected site. Apocrine gland-bearing areas, such as the axilla, were affected less often. The proportion of HS patients with wet earwax was 51%, which was substantially higher than that found in the general Japanese population. Moreover, when patients with gluteal HS were excluded, the proportion of patients with wet earwax became even higher (68%). Conclusions Although the etiology of HS is unknown, our survey indicated that HS in apocrine gland-bearing skin, such as the axillary and anogenital areas, may be associated with wet earwax. As this study was conducted in a limited clinical setting, a nationwide, multicenter survey is warranted to clarify the clinical characteristics of HS in Japan.

Regulation of Immune Responses by the Activating and Inhibitory Myeloid-Associate Immunoglobuline-Like Receptors (MAIR) (CD300)

Shibuya, Akira,Nakahashi-Oda, Chigusa,Tahara-Hanaoka, Satoko The Korean Association of Immunobiologists 2009 Immune Network Vol.9 No.2

Activating and inhibitory cell surface receptors play important roles in regulation of immune responses. Recent progress has demonstrated that many inhibitory receptors pair with activating, as well as inhibitory, isoforms, both of whose genes are located in small clusters on a chromosome. We and others identified paired activating and inhibitory immunoglobulin-like receptors, designated myeloid-associated immunoglobulin-like receptors (MAIR) (CD300). MAIR is a multigene family consisting of nine genes on a small segment of mouse chromosome 11. MAIR family receptors are preferentially expressed on myeloid cells, including macrophages, dendritic cells, granulocytes, and bone-marrow-derived cultured mast cells, and a subset of B cells and regulate activation of these cells. Thus, MAIR plays an important role in innate immunity mediated by myeloid cells.

Differential Roles of Vascular Endothelial Growth Factor Receptor-1 and Receptor-2 in Angiogenesis

Shibuya, Masabumi Korean Society for Biochemistry and Molecular Biol 2006 Journal of biochemistry and molecular biology Vol.39 No.5

Vascular endothelial growth factor (VEGF)-A, a major regulator for angiogenesis, binds and activates two tyrosine kinase receptors, VEGFR1 (Flt-1) and VEGFR2 (KDR/Flk-1). These receptors regulate physiological as well as pathological angiogenesis. VEGFR2 has strong tyrosine kinase activity, and transduces the major signals for angiogenesis. However, unlike other representative tyrosine kinase receptors which use the Ras pathway, VEGFR2 mostly uses the Phospholipase-$C{\gamma}$-Protein kinase-C pathway to activate MAP-kinase and DNA synthesis. VEGFR2 is a direct signal transducer for pathological angiogenesis including cancer and diabetic retinopathy, thus, VEGFR2 itself and the signaling appear to be critical targets for the suppression of these diseases. VEGFR1 plays dual role, a negative role in angiogenesis in the embryo most likely by trapping VEGF-A, and a positive role in adulthood in a tyrosine kinase-dependent manner. VEGFR1 is expressed not only in endothelial cells but also in macrophage-lineage cells, and promotes tumor growth, metastasis, and inflammation. Furthermore, a soluble form of VEGFR1 was found to be present at abnormally high levels in the serum of preeclampsia patients, and induces proteinurea and renal dysfunction. Therefore, VEGFR1 is also an important target in the treatment of human diseases. Recently, the VEGFR2-specific ligand VEGF-E (Orf-VEGF) was extensively characterized. Interestingly, the activation of VEGFR2 via VEGF-E in vivo results in a strong angiogenic response in mice with minor side effects such as inflammation compared with VEGF-A, suggesting VEGF-E to be a novel material for pro-angiogenic therapy.

Profile Measurements of Micro-aspheric Surfaces Using an Air-bearing Stylus with a Microprobe

Shibuya, Atsushi,Gao, Wei,Yoshikawa, Yasuo,Ju, Bing-Feng,Kiyono, Satoshi Korean Society for Precision Engineering 2007 International Journal of Precision Engineering and Vol.8 No.2

A novel scanning probe measurement system was developed to enable precise profile measurements of microaspheric surfaces. An air-bearing stylus with a microprobe was used to perform the surface profile scanning. The new system worked in a contact mode and had the capability of measuring micro-aspheric surfaces with large tilt angles and complex profiles. Due to limitations resulting from the contact mode, such as possible damage caused by the contact force and lateral resolution restrictions from the curvature of the probe tip, several system improvements were implemented. An air bearing was used to suspend the shaft of the probe to reduce the contact force, enabling fine adjustments of the contact force by changing the air pressure. The movement of the shaft was measured by a linear encoder with a scale attached to the actual shaft to avoid Abbe errors. A $50-{\mu}m-diameter$ glass sphere was bonded to the tip of the probe to improve the lateral resolution of the system. The maximum contact force of the probe was 10 mN. The shaft was capable of holding the probe continuously if the contact force was less than 40 mN, and the resolution of the probe could be as high as 10 nm, The performance of the new scanning probe measurement system was verified by experimental data.

Influence of 10-MDP concentration on the adhesion and physical properties of self-adhesive resin cements

Shibuya, Kazuhiko,Ohara, Naoko,Ono, Serina,Matsuzaki, Kumiko,Yoshiyama, Masahiro The Korean Academy of Conservative Dentistry 2019 Restorative Dentistry & Endodontics Vol.44 No.4

Objectives: Self-adhesive resin cements contain functional monomers that enable them to adhere to the tooth structure without a separate adhesive or etchant. One of the most stable functional monomers used for chemical bonding to calcium in hydroxyapatite is 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP). The aim of this study was to evaluate the influence of the10-MDP concentration on the bond strength and physical properties of self-adhesive resin cements. Materials and Methods: We used experimental resin cements containing 3 different concentrations of 10-MDP: 3.3 wt% (RC1), 6.6 wt% (RC2), or 9.9 wt% (RC3). The micro-tensile bond strength of each resin cement to dentin and a hybrid resin block (Estenia C&B, Kuraray Noritake Dental) was measured, and the fractured surface morphology was analyzed. Further, the flexural strength of the resin cements was measured using the three-point bending test. The water sorption and solubility of the cements following 30 days of immersion in water were measured. Results: The bond strength of RC2 was significantly higher than that of RC1. There was no significant difference between the bond strength of RC2 and that of RC3. The water sorption of RC3 was higher than that of any other cement. There were no significant differences in the three-point bending strength or water solubility among all three types of cements. Conclusions: Within the limitations of this study, it is suggested that 6.6 wt% 10-MDP showed superior properties than 3.3 wt% or 9.9 wt% 10-MDP in self-adhesive resin cement.

Profile Measurements of Micro-aspheric Surfaces Using an Air-bearing Stylus with a Microprobe

Atsushi Shibuya,Wei Gao,Yasuo Yoshikawa,Bing-Feng Ju,Satoshi Kiyono 한국정밀공학회 2007 International Journal of Precision Engineering and Vol.8 No.2

A novel scanning probe measurement system was developed to enable precise profile measurements of micro-aspheric surfaces. An air-bearing stylus with a microprobe was used to perform the surface profile scanning. The new system worked in a contact mode and had the capability of measuring micro-aspheric surfaces with large tilt angles and complex profiles. Due to limitations resulting from the contact mode, such as possible damage caused by the contact force and lateral resolution restrictions from the curvature of the probe tip, several system improvements were implemented. An air bearing was used to suspend the shaft of the probe to reduce the contact force, enabling fine adjustments of the contact force by changing the air pressure. The movement of the shaft was measured by a linear encoder with a scale attached to the actual shaft to avoid Abbe errors. A 50-㎛-diameter glass sphere was bonded to the tip of the probe to improve the lateral resolution of the system. The maximum contact force of the probe was 10 mN The shaft was capable of holding the probe continuously if the contact force was less than 40 mN, and the resolution of the probe could be as high as 10 ㎚. The performance of the new scanning probe measurement system was verified by experimental data.

Ground beetle community in suburban Satoyama — A case study onwing type and body size under small scale management

Sonomi Shibuya,Zaal Kikvidze,Wataru Toki,Yasuto Kanazawa,Tatsuya Suizu,Tamio Yajima,Takahiro Fujimori,Mohammad Reza Mansournia,Zuhair Sule,Kôhei Kubota,Kenji Fukuda 한국응용곤충학회 2014 Journal of Asia-Pacific Entomology Vol.17 No.4

A Satoyama landscape is an important reservoir of biodiversity; however, in post-industrial era traditionalSatoyama management became economically unfeasible. To maintain Satoyama, labor-saving management styles have begun to be implemented. In contrast to thetraditional styles based on labor-intensive practices such as rotational tree clear-cutting, the labor-saving stylesconsist mainly in tree thinning and ground vegetation cutting within a small spatial range. The consequencesof this newapproach are unclear, and our study aimed at filling this gap in our knowledge by analyzing the effectsofsmall scalemanagement on ground beetle community in suburban Satoyama (Kashiwacity, central Japan).Weapplied labor-savingmanagement at limited spatial range, and sampled and analyzed ground beetles both beforeand after management. Cluster analysis revealed three groups of beetle assemblages, corresponding to threehabitats: forest, bamboo stand and grassland. Comparison of wing traits showed that, before management, brachypterousbeetles dominated forest plots and macropterous beetleswere more prominent in the grassland plot,while in the bamboo stand both types of wing morphology were evenly represented. This trend can be linked tohabitat structural stability driven by vegetation regeneration cycleswhich reflect dominant plant longevity. Aftermanagement, macroptery increased in all three habitats. Probably, habitat disturbance created by vegetationmanagement gave advantage to macropterous beetles over brachypterous beetles. These results suggest thatwing type can be linked to vegetation structural stability. In some species, decline in abundance was accompaniedwith decline in body size. Our study shows that small scale Satoyama management can have pronouncedeffects on beetle assemblages.