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Haibing He,Xing Tang,Bo Shi,Cuifang Cai 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.11
The poorly water-soluble drug lovastatin (LVA) is an inhibitor of 3-hydroxy-3-methylglutarylcoenzyme A reductase and has a slow dissolution rate. In this study, a microcrystal dispersion (MCD) technique was used in the preparation of LVA to increase its dissolution rate and then combining with an extrusion-spheronization method, microcrystalline cellulose (MCC) matrix sustained-release pellets containing LVA-MCD were developed and characterized in vitro. Photomicrographs indicated that LVA-MCD existed as fine crystals, of which the mean particle size was reduced from 65.75 μm to 3.97 μm and the dried LVA-MCD powders released completely within 2 hours. SEM results during the release process showed that pellets possessed a matrix structure and after the dissolution test, this matrix structure became loose and porous. The release of LVA was fast and complete, and accumulated release by the optimal formulation was: 0.5 h (20.23 ± 3.40%), 2 h (56.87 ± 2.85%), 4 h (78.71 ± 3.42%), and 8 h (96.81 ± 3.30%). The 3 months accelerating test at 40^oC and 75% RH demonstrated that drug release of pellets was not changed and drug degradation was less than 1%. Thus, a novel MCD process with MCC matrix was feasible and effective to get complete release without a lag time for the poorly water soluble drug, LVA, with high stability.
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Zhang Lang,Li Xuewu,Wang Yuping,Wang Qiang,Shi Haibing 대한기계학회 2013 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.27 No.12
Influence of different electrical boundary conditions (BCs) on the elasticity solutions of piezoelectric plane beam (PPB) is investigated using analytical technique. The first case is considering electrical displacement of the two longitudinal sides of PPB. The second case is electrical potential. Firstly, the unified equations to obtain the elasticity solutions of PPB corresponding to these two cases are given briefly. Secondly, two examples are given to verify the correctness of the theoretical formulations presented in this paper. Finally, the responses of PPB acted by the same mechanical loads but with different electrical BCs are compared.
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