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- 저자 : Shehata Sayed (검색결과 3 건)
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Seismic pounding effects on adjacent buildings in series with different alignment configurations
Shehata E. Abdel Raheem,Mohamed Y.M. Fooly,Aly G.A. Abdel Shafy,Yousef A. Abbas,Mohamed Omar,Mohamed M.S. Abdel Latif,Sayed Mahmoud 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.28 No.3
Numerous urban seismic vulnerability studies have recognized pounding as one of the main risks due to the restricted separation distance between neighboring structures. The pounding effects on the adjacent buildings could extend from slight non-structural to serious structural damage that could even head to a total collapse of buildings. Therefore, an assessment of the seismic pounding hazard to the adjacent buildings is superficial in future building code calibrations. Thus, this study targets are to draw useful recommendations and set up guidelines for potential pounding damage evaluation for code calibration through a numerical simulation approach for the evaluation of the pounding risks on adjacent buildings. A numerical simulation is formulated to estimate the seismic pounding effects on the seismic response demands of adjacent buildings for different design parameters that include: number of stories, separation distances; alignment configurations, and then compared with nominal model without pounding. Based on the obtained results, it has been concluded that the severity of the pounding effects depends on the dynamic characteristics of the adjacent buildings and the input excitation characteristics, and whether the building is exposed to one or two-sided impacts. Seismic pounding among adjacent buildings produces greater acceleration and shear force response demands at different story levels compared to the no pounding case response demands.
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Refaie Marwa Monier Mahmoud,Shehata Sayed,El-Hussieny Maram,Fawzy Michael Atef,Ahmed Nagwa Zenhom Mustafa,Marey Heba,Hishmat Asmaa Mohammed,Alkully Turki,Rahman Eman Shaaban Mahmoud Abd El 한국독성학회 2024 Toxicological Research Vol.40 No.1
One of the commoly used chemotherapeutic agents is 5-Fluorouracil (5-FU). Unfortunately, the clinical administration of 5-FU is complicated with serious cardiotoxic effects and the safe use becomes an urgent task in cardio-oncology. Till now, there are no studies discussed the role of empagliflozin (EMP) against 5-FU cardiotoxicity. Thus, we investigated this effect and the involved mechanisms in 5-FU induced heart injury. Forty male rats of Wistar albino species were used and divided randomly into four groups. Group I is the control group, group II is EMP given group, group III is 5-FU cardiotoxic group and group IV is 5-FU plus EMP group. 5-FU (150 mg/kg) was administered as a single intraperitoneal (i.p.) dose on 1st day to induce cardiotoxicity with or without EMP (30 mg/kg/d) orally for 5 days. The dose of 5-FU is relevant to the human toxic dose. Our data showed that 5-FU given group caused cardiotoxicity with significant increase of serum cardiac enzymes, toll like receptors, enhancement of nuclear factor kappa B (NF-κB), interleukin1β (IL1β), IL6, myeloid-differentiation-factor 88 (MYD88), heart weight, malondialdehyde (MDA), tumor-necrosis-factor-alpha (TNFα), sodium glucose co-transporter 2 (SGLT2), P53 and caspase3 expression with clear histopathological features of cardiotoxicity. Moreover, there is a significant decrease in reduced glutathione (GSH) and total antioxidant capacity (TAC). Interestingly, co-administration of EMP could ameliorate 5-FU induced biochemical and histopathological changes. This effect may be due to modulation of SGLT2, decreasing inflammation, oxidative stress and apoptosis with downregulation of an essential inflammatory cascade that mediates 5-FU cardiotoxicity; TNFα/TLR/NF-κB.
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Ahmed Mohammed Elbeltagy,Wadida Hassan El Sayed,Soheir Shehata Rezk Allah 대한척추외과학회 2018 Asian Spine Journal Vol.12 No.5
Study Design: Prospective observational study. Purpose: To test the face validity, content validity, feasibility, internal consistency, reliability, and test–retest reliability of the Arabic version of the Copenhagen Neck Functional Disability Scale (CNFDS). Overview of Literature: CNFDS is a clinical evaluation tool that accurately reflects the patient’s perception regarding his/her functionality with existing cervical pain. This study aimed to investigate the validity and reliability of the Arabic version of the CNFDS in measuring the disability level in chronic neck pain patients. Method: Seventy-four patients with neck pain were recruited, and 135 sheets (test and retest sheets) were completed by patients; two expert panels (each comprising ten experts) participated in this study. Arabic translation (forward translation), development of the preliminary translated version, English translation (backward translation), development of the prefinal version, and testing of the prefinal version was performed by experts; thereafter, the final version was tested on patients. Index of clarity, expert proportion of clearance, index of content validity (CVI), expert proportion of relevance, descriptive statistics, missed item index, Cronbach’s alpha, and Spearman’s rank correlation coefficient were used for statistical analyses. Results: The study revealed that the scale index of clarity was 86.84%, scale CVI was 99.33%, scale-level content validity index (universal agreement method) was 99.33%, 99.15% of the scale items were filled in all sheets, the scale was answered in less than 3 minutes in about 75% cases, Cronbach’s alpha was 0.856 (0.796, 0.905), and all Spearman’s correlations between the test and retest results were statistically significant. Conclusions: The Arabic version of the CNFDS has adequate validity and reliability for the measurement of the disability level in chronic neck pain patients.
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