Silencing IL-23 expression by a small hairpin RNA protects against asthma in mice

Li, Yanchun,Sun, Meng,Cheng, Huanji,Li, Shanyu,Liu, Li,Qiao, Hongmei,Hua, Shucheng,Lu, Jirong Korean Society for Biochemistry and Molecular Bion 2011 Experimental and molecular medicine Vol.43 No.4

To determine the impact of IL-23 knockdown by RNA interference on the development and severity of ovalbumin (OVA)-induced asthmatic inflammation, and the potential mechanisms in mice, the IL-23-specific RNAi-expressing pSRZsi-IL-23p19 plasmid was constructed and inhaled into OVA-sensitized mice before each challenge, as compared with that of control mice treated with alum or budesonide. Inhalation of the pSRZsi-IL-23p19, significantly reduced the levels of OVA-challenge induced IL-23 in the lung tissues by nearly 75%, determined by RT-PCR. In addition, knockdown of IL-23 expression dramatically reduced the numbers of eosinophils and neutrophils in BALF and mitigated inflammation in the lungs of asthmatic mice. Furthermore, knockdown of IL-23 expression significantly decreased the levels of serum IgE, IL-23, IL-17, and IL-4, but not IFN${\gamma}$, and its anti-inflammatory effects were similar to or better than that of treatment with budesonide in asthmatic mice. Our data support the notion that IL-23 and associated Th17 responses contribute to the pathogenic process of bronchial asthma. Knockdown of IL-23 by RNAi effectively inhibits asthmatic inflammation, which is associated with mitigating the production of IL-17 and IL-4 in asthmatic mice.

Dynamic and static structural displacement measurement using backscattering DC coupled radar

Shanyue Guan,Jennifer A. Rice,Changzhi Li,Yiran Li,Guochao Wang 국제구조공학회 2015 Smart Structures and Systems, An International Jou Vol.16 No.3

Vibration-based monitoring is one approach used to perform structural condition assessment. By measuring structural response, such as displacement, dynamic characteristics of a structure may be estimated. Often, the primary dynamic responses in civil structures are below 5 Hz, making accurate low frequency measurement critical for successful dynamic characterization. In addition, static deflection measurements are useful for structural capacity and load rating assessments. This paper presents a DC coupled continuous wave radar to accurately detect both dynamic and static displacement. This low-cost radar sensor provides displacement measurements within a compact, wireless unit appropriate for a range of structural monitoring applications. The hardware components and operating mechanism of the radar are introduced and a series of laboratory experiments are presented to assess the performance characteristics of the radar. The laboratory and field experiments investigate the effect of factors such as target distance, motion amplitude, and motion frequency on the radar’s measurement accuracy. The results demonstrate that the radar is capable of both static and dynamic displacement measurements with sub-millimeter accuracy, making it a promising technology for structural health monitoring.

Silencing IL-23 expression by a small hairpin RNA protects against asthma in mice

Yanchun Li,Shucheng Hua,Jirong Lu,Meng Sun,Huanji Cheng,Shanyu Li,Li Liu,Hongmei Qiao 생화학분자생물학회 2011 Experimental and molecular medicine Vol.43 No.4

To determine the impact of IL-23 knockdown by RNA interference on the development and severity of ovalbumin (OVA)-induced asthmatic inflammation, and the potential mechanisms in mice, the IL-23-specific RNAi-expressing pSRZsi-IL-23p19 plasmid was constructed and inhaled into OVA-sensitized mice before each challenge, as compared with that of control mice treated with alum or budesonide. Inhalation of the pSRZsi-IL-23p19, significantly reduced the levels of OVA-challenge induced IL-23 in the lung tissues by nearly 75%, determined by RT-PCR. In addition, knockdown of IL-23 expression dramatically reduced the numbers of eosinophils and neutrophils in BALF and mitigated inflammation in the lungs of asthmatic mice. Furthermore, knockdown of IL-23 expression significantly decreased the levels of serum IgE, IL-23,IL-17, and IL-4, but not IFNγ, and its anti-inflammatory effects were similar to or better than that of treatment with budesonide in asthmatic mice. Our data support the notion that IL-23 and associated Th17 responses contribute to the pathogenic process of bronchial asthma. Knockdown of IL-23 by RNAi effectively inhibits asthmatic inflammation, which is associated with mitigating the production of IL-17 and IL-4 in asthmatic mice.

企业社会责任对财务业绩的影响研究: 以中国中小企业为对象

主力 ( Li Zhu ),金山月 ( Shanyue Jin ) 사단법인 아시아문화학술원 2021 인문사회 21 Vol.12 No.3

过去的研究对企业社会责任和财务业绩的关系没有做出统一的观点是因为没有考虑到其他因素的中介作用。本文的目的是将管理创新和生产性作为中介变量考察企业社会责任活动和财务业绩之间的关系。本文收集问卷调查后进行信度和效度分析, 为了进行假设检验进行实证分析, 统计软件使用SPSS 25.0。本文的结论是, 社会责任对财务业绩是有正向影响, 其中管理创新和生产性有部分中介作用。本研究的启示是作为可持续发展的企业社会责任活动要考虑到管理创新的生产性的因素。 The reason why preceding research failed to present a unified view on the relationship between corporate social responsibility (CSR) and financial performance is that it did not consider the mediating effects of other factors. The purpose of this study is to consider the impact of CSR on financial performance using management innovation and productivity as parameters. We conducted reliability analysis and feasibility analysis, followed by regression analysis for hypothesis verification using the statistical package SPSS 25.0. We have found that CSR has a positive impact on financial performance and that management innovation and productivity have partial parametric effects. The implication is that CSR activities for sustainable development should consider the effects of management innovation and productivity.

The Influence of Stock Ownership Structure on the Effectiveness of Internal Control

Yingnan Li,Shanyue Jin,Hyeongsop Shim 한국무역연구원 2021 무역연구 Vol.17 No.3

Purpose Improving the effectiveness of internal control has become the key to ensure the healthy development of China’s listed companies and safeguard their interests. Corporate governance and ownership structure will affect the implementation of internal control of listed companies. This paper empirically tests the effects of ownership concentration, institutional ownership and executive ownership on the internal control of listed companies and their influencing mechanisms. Design/Methodology/Approach Based on the data of all A-shares in Shanghai and Shenzhen stock markets from 2015 to 2019, this paper builds a utility model based on the principal-agent theory, and uses SPSS22.0 software to conduct an empirical study. Findings We find that ownership centralization has a significant positive correlation with effectiveness of internal control, which can appropriately improve the degree of ownership concentration and internal control. There is a significant positive correlation between the institutional shareholding ratio and the executive shareholding ratio and internal control. The listed company can introduce diversified investment subjects to realize the diversified power balance mechanism. Moreover, through the improvement of a good holding ratio, to the greatest extent to meet the income between different shareholders, improve the corporate governance structure, and then improve the effectiveness of internal control. Research Implications Results show that there is no significant correlation between the degree of equity balance and the effectiveness of internal control. Different degrees of checks and balances have different positive effects on the effectiveness of internal control.

Preparation of Nanoflake Bi₂MoO₆ Photocatalyst Using CO(NH₂)₂ as Structure Orientation and Its Visible Light Degradation of Tetracycline Hydrochloride

Hu, Pengwei,Zheng, Dewen,Xian, Yuxi,Hu, Xianhai,Zhang, Qian,Wang, Shanyu,Li, Mingjun,Cheng, Congliang,Liu, Jin,Wang, Ping Materials Research Society of Korea 2021 한국재료학회지 Vol.31 No.6

Bi₂MoO₆ (BMO) via the structure-directing role of CO(NH₂)₂ is successfully prepared via a facile solvothermal route. The structure, morphology, and photocatalytic performance of the nanoflake BMO are characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), fluorescence spectrum analysis (PL), UV-vis spectroscopy (UV-vis) and electrochemical test. SEM images show that the size of nanoflake BMO is about 50 ~ 200 nm. PL and electrochemical analysis show that the nanoflake BMO has a lower recombination rate of photogenerated carriers than particle BMO. The photocatalytic degradation of tetracycline hydrochloride (TC) by nanoflake BMO under visible light is investigated. The results show that the nanoflake BMO-3 has the highest degradation efficiency under visible light, and the degradation efficiency reached 75 % within 120 min, attributed to the unique hierarchical structure, efficient carrier separation and sufficient free radicals to generate active center synergies. The photocatalytic reaction mechanism of TC degradation on the nanoflake BMO is proposed.