영양 장애 환자에 대한 지질 영양 수액제 "Trive-1000^(R)"의 효과에 대한 연구

손기섭,배진선,장일성,노승무,박인근,김지연 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2

The association between malnutrition and poor hospital course in surgical patients is well recognized, although it may not involve the causation. When the period of NPO is needed more than several weeks, adequate caloric intake is difficult to maintain, and nutritional status often worsens especially after the operation. Trive-1000^(R) is a ready to use industrial ternary mixture. It fulfills standard requirements for TPN and has a advantage to decrease the cost because of time saving in preparation by the pharmacist and cost saving in disposables(transter sets, bags, filters). It improves safety by less risk of contamination and of error from handling and labelling. A prospective study was undertaken to evaluate the efficacy of Trive-1000^(R) in 34 malnourished patients after the major operation and the results were summarized as follows ; 1) The hemoglobin was not changed and AST, ALT, and bilirubin were increased and BUN and alkaline phosphatase were slightly increased without significance. 2) Mild to moderate toxicities including fever and chill, hepatopathy, thrombophlebitis and hyperglycemia. The infusion was discontinued in one of thrombophlebitis and one of hepatopathy. There results suggest that Trive-1000^(R) is relatively effective and safe TPN agents but requires the large scaled prospective randomized study.

西歐 代替醫學의 癌 治療에 關한 硏究

兪和承,李容淵,徐祥熏,崔宇鎭,曺政孝,李淵月,孫彰奎,趙鍾寬 대한한방종양학회 2000 대한한방종양학회지 Vol.6 No.1

At here, we investigated the historical background, current stage, and concrete therapies of altematives in cancer therapy. We obatined the conclusion below. 1. Alternative medicine(AM) is a unothodoxial medical physiology, medical practice or intervension that overcome the side effects. faults, limits of coventional medicine. 2. Recentely, as emerging New-age movement, collgpse of Decarte's mecanical cosmology, and emphasis on patient rights, the interest of AM is increased, and foreign & domestic use rates of AM are risen. 3. After coventional medicine in cancer therapies tha depends on poerations, radiations, and chemotherapy is bounded, Altematives in cancer therapy are rapidly developed, and the majority of users are often considered satisfactory. 4. Alternatives in cancer therapy are classified six boundaries; Diet and Nutrition, MInd-body Technique, Integrated System, Pharmacologic and Biologictreatments, Immuno Enhanced Therapy, Immuno Enthaced Therapy, Natural and herbal medicine. 5. Looking at contents of Alternatives in cancer therapy, we get to know most of them are similar to the treatment of oriental medicine in holistic method, therapy, philosophy. If we synthesize the alternative medicine's treatment mentioned above and investigate it with oriental medical viewpoint, that may help us approach the conquest of cancer and improve the rate of cure. that may help us approach the conquest of cancer and improve the rate of cure. 6. It is certain that foreign AM will be imported reversely, and we must prepare for rebuilding of Korean traditional AM systemically, investing for activity positively, making national policy for medical system.

치수/치근단 질환에 이환된 영구치의 치수 조직 재생과 치근 형성

유연지,백승호,손호현 大韓齒科保存學會 2010 Restorative Dentistry & Endodontics Vol.35 No.4

최근 치수 질환 또는 치근단 질환을 가진 미성숙 영구치에 대한 보존적 치료의 방법으로 여러가지 근관 내 소독 약제를 이용하에 증상 개선은 물론 치근의 성장 및 치수의 재생이 이루어진 증례들이 보고되고 있다. 그 기전에 대해서는 아직 명확하게 밝혀지지는 않았지만 여러가지 줄기 세포 또는 미분화 간엽 세포들이 관여하는 것으로 생각되며, 실제로 재생된 조직에서는 대부분백악질양또는골양물질의 침착이 관찰되고 있다. 이 새롭고보존적인 치료접근 방법은 다능성 줄기 세포와 다양한조직 공학 기술에 대한 연구와 더불어, 재생적 근관 치료에 더 밝은 비전을 제시하고 있다. Numerous cases about additional growth of roots or pulp tissue regeneration by using various intracanal medicaments in immature permanent teeth with periapical or pulpal disease have been reported. The underlying mechanism has not been clearly delineated. but it has been widely accepted that undifferentiated mesenchymal cells and stem cells are involved. Moreover, the growth and deposition of osteoid or cementoid tissues have been observed in regenerated pulp and roots. This new and non-invasive treatment has brightened the future of endodontics. and enlarged the vision of regenerative root canal treatment with multi-potent stem cells and various tissue engineering techniques.

抗癌丹을 投與한 胃癌 患者 105例에 對한 臨床報告

유화승,최우진,이용연,서상훈,조정효,이연월,손창규,조종관 대전대학교 한방병원 2000 惠和醫學 Vol.9 No.2

Clinical studies were carried out 105 cases of patients with stomach cancer treated by Hangamdan(抗癌丹) from January 1th 1998 to September 30th 2000. The results were summarized as follows; 1. Distribution of those attached by stomach cancer, by sex, showed that Male is more then Female, by age, showed that the number of forties, fifties, sixties are majority. 2. Distribution of diagnostic stage, in descending order; stage Ⅲ(45.1%, top), stage Ⅳ(40.2%). 3. The effects of maintenance and improvement in the symptoms with traditional oriental therapy(77.8%) and combined treatment of western and oriental therapy(92.3%) were observed. The effects of the symptoms were as follows; abdominal pain (16.3%), general body weakness(10.5%), nausea&vomiting (8.6%), diarrhea(6.7%) and etc, in orders. 4. Analysis of hematology attached by stomach cancer, maintenance and increasing of WBC(89.4%), RBC(63.6%), Hgb(62.3%), Platelet(95.6%) were observed. After taken Hangamdan, the safety of the liver and kidney were as follows; maintenance and decreasing of AST(85.3%), ALT(91.6%), BUN(84.8%), Creatinine(92.4%) were observed. 5. Analysis of IL-12 and IFN-γ attached by stomach cancer, increasing of IL-12(39.1%), IFN-γ(69.6%) were observed. 6. Analysis of QOL attached by stomach cancer, maintenance and improvement of combined treatment of western and oriental therapy(91%), traditional oriental therapy(85.2%) were observed. 7. Analysis of survival in patients with Ⅳ stage of stomach cancer, above 6 months(17.1%), 12 months(85.2%) were observed. 8. Analysis of antitumor effects, maintenance of traditional oriental therapy(81.5%) and maintenance and improvement of combined treatment of western and oriental therapy(89.7%) were observed. Analysis of tumor marker attached by stomach cancer, maintenance of CEA(85.7%) were observed. 9. Analysis of curative valuation, maintenance and improvement of traditional oriental therapy(77.7%), combined treatment of western and oriental therapy(82.1%) were observed. From the above results, it is suggested that Hangamdan has significant effects of antitumor and immune activity, also could be usefully applied for stomach cancer patients by combination with western therapy or alone.

하악 대구치에서 근관세척방법에 따른 잔사제거효과에 대한 평가

이소영,손원준,이우철,금기연,배광식,백승호 대한치과보존학회 2009 Restorative Dentistry & Endodontics Vol.34 No.3

본 연구의 목적은 isthmus가 존재하는 하악 대구치의 근심 근관에서 근관세척방법에 따른 잔사제거효과를 평가하는 것이다. 45개의 하악 대구치의 근심근관을 #30 Profile .06까지 확대하였다. 각 근관을 3개의 군으로 나누고 conventional irrigation syringe와 초음파, RinsEndo를 사용하여 1분간 최종 세척하였다. 조직표본을 제작한 후, 광학현미경으로 치근단 1, 3, 5 mm 부위의 단면을 관찰하였다. 근관과 isthmus의 잔사 양으로 청결도를 계산하고 Mann-Whitney U test로 검정하였다. 1. 초음파 군과 syringe 군은 5 mm 부위의 isthmus를 제외한 나머지 부위에서 청결도의 유의한 차이가 없었다. 2. RinsEndo군은 syringe 군에 비해 1 mm, 3 mm 부위의 근관과, 모든 부위의 isthmus에서 유의하게 높은 청결도를 나타내었다(p<0.05). 3. 초음파 군과 RinsEndo 군은 3 mm 부위의 근관을 제외한 나머지 부위에서 청결도의 유의한 차이가 없었다. 임상적으로 RinsEndo를 이용한 근관세척방법의 부가적인 적용이 하악 대구치의 근심근관의 잔사제거에 효과가 있을 것으로 사료된다. The aim of this in vitro study was to evaluate the cleaning efficacy of various irrigation methods in the mandibular mesial roots. The forty five mesial root canals were shaped by Profile .06 instruments to apical size #30 and irrigated with 5 ml of 3.5% NaOCl. The teeth were divided into 3 groups and irrigated finally for 1 minute; Group 1: syringe irrigation, Group 2: ultrasonic irrigation, Group 3: RinsEndo irrigation. After histological processing, the cross sections of apical 1, 3, and 5 mm level were examined with an optical microscope. The cleanliness values of canals and isthmuses were calculated and analyzed by Mann-Whitney U test. 1. There were no significant differences in both canal and isthmus cleanliness between syringe irrigation and ultrasonic irrigation except 5 mm level of isthmus. 2. RinsEndo irrigation had significantly higher canal cleanliness values than syringe irrigation at 1 mm and 3 mm levels (p<0.05). Also, RinsEndo irrigation had significantly higher isthmus cleanliness VaIues than syringe irrigation at all levels evaluated (p<0.05). 3. There were no statistical differences in both canal and isthmus cleanliness between ultrasonic irrigation and RinsEndo irrigation except 3 mm level of canal. From this study, RinsEndo irrigation can be useful as an additional irrigation procedure.

다중주파수·다중성분 고막운동도에 관한 연구

소원섭,이지연,강희라,손원진,허승덕 대구대학교 특수교육재활과학연구소 2012 再活科學硏究 Vol.30 No.1

이 연구는 이학적·청각학적 정상 소견을 가진 성인들의 다중주파수 고막운동도(multi-frequency tympanogram, MFT)와 다중성분 고막운동도(multi-component tympanogram, MCT)의 특성을 알아보고자 하였다. 연구 참여자는 D대학교 재학 중인 19명(M:F=9:10, 만 19∼23세)으로 하였다. MCT는 각 성분(admittance; Y, susceptance; B, conductance; G)별 정점의 수를 확인하였고, MFT는 200 ㎐부터 2 ㎑ 순음에 대한 고막 긴장 및 이완상태에서 전도율을 통해 공명주파수와 ΔB, Δ∅를 각각 구하였다. MCT는 668 ㎐ 자극에 대해 47.4 %가 1Y1B1G를, 52.6 %가1Y3B1G를 보였고, MFT의 공명주파수는 829~1,213(1,021±192) ㎐, ΔB와 Δ∅의 평균은 각각 –0.18, -19.3으로 관 찰되었다. This study will be to confirm the characteristic of Multi-component tympanogram(MCT) and Multi-frequency tympanogram(MFT) of adults who have physical and audiological normal findings. Participants were 19 students(M:F = 9:10) who are attending D-university. MCT checked the number of peaks per each component(admittance; Y, susceptance; B, conductance; G) and MFT got the resonance frequency through the conductivity rate of tympanic membrane's tense and relaxation state, and ΔB, Δ∅ respectively. 47.4% of MCT showed 1Y1B1G about 668 ㎐ stimulus and 52.6% of that showed 1Y3B1G. Resonance frequency of MFT was 829~1,213(1,021±192) ㎐, and the average of ΔB and Δ∅ was observed -0.18, -19.3 respectively.

急性 骨髓性 白血病 患者 1例에 對한 臨床報告

조정효,유화승,최우진,이용연,서상훈,이연월,손창규,조종관 대전대학교 한방병원 2000 惠和醫學 Vol.9 No.2

AML is the most common type of leukemia in adults. AML(acute myeloid leukaemia) is characterised by a rapid accumulation of abnormal white blood cells in the blood and bone marrow, resulting in severe anemia, and possibly infection, and hemorrhage during the course of the disease. In general the prognosis of patient with relapsed AML is poor. At this time, however, the only potentially curative therapy for relapsed patients is allogeneic BMT(bone marrow transplantation). This clinical study were carried out 1 case of female patient aged 44 with relapsed AML treated by herb medicine. At the time of admission, she complained of mild fever, nausea, vomitting, abdominal pain, anorexia and no sign of bleeding. For the 10 days of admission, she was treated with Oriental-Western medicine and all the symptoms were disappeared. After that, the syptoms were aggravated because of secondary infection. Anyway, above result showed the possibility of Oriental therapy as Supportive Care in AML.

간호사의 이직의도 구조모형

김창희,양승순,김연자,손연정,유미애,송주은 대한간호학회 간호행정학회 2009 간호행정학회지 Vol.15 No.4

Purpose: The purpose of this study was to construct and test a structural equation model of nurses' turnover intention. Method: The participants were 716 nurses at 4 university hospitals. Data were collected by a self-report questionnaire in 2008 and analyzed using SPSS 12.0 and AMOS 4.0 Win program. Results: The fit indices of modified model were x²=285.928(p<.001),x²/df=1.958GFI=0.964, RMSEA=0.037, AGFI=0.944, NFI=0.947, NNFI=0.961, CFI=0.973, PNFI=0.658 and showed high compatibility with the empirical data. In the final model, job stress and satisfaction were found to have significant direct effects on nurses' turnover intention, while organizational culture and emotional labor were very important factors to have indirect effects on turnover intention via job stress and satisfaction. Nurses' turnover intention was accounted for 41.2% of covariance by these factors. Conclusions: Comprehensive nursing interventions for decreasing nurses' turnover intention should be focused on reducing job stress and increasing job satisfaction. Also, Nursing strategy for enhancing positive organizational culture and decreasing emotional labor would be helpful for decreasing nurses' turnover intention, too. Further studies are needed to prospectively conduct to verify these causal relationships with larger sample.

抗癌丹을 投與한 各種 癌患者 320例에 對한 考察

曺政孝,兪和承,李淵月,孫彰奎,趙鍾寬 대전대학교 한의학연구소 2004 혜화의학회지 Vol.12 No.2

The purpose of this study was to investigate the effects of Hangamdan(抗癌丹). The clinical study was carried out 320 cases of patients with cancer treated by Hangamdan(抗癌丹) from May 1st 1998 to September 1st 1999. The results were summarized as follows; 1. The effects of improvement in the symptoms with traditional oriental cancer therapy(47.6%) were higher than combined treatment of western and oriental therapy(37.4%). 2. In the analysis of hematology, maintenance and increasing of WBC(86.2%), Hgb(87.2%), Platelet(97.6%) RBC(81.1%) were Observed. In the analyses of tumor marker, maintenance and decreasing of CEA(76%), CA19-9(88.8%), AFP(69.2%) were observed. 3. In the analysis of safety, maintenance and decreasing of AST(93.1%), AL.T(95%), BUN(92.2%), Creatinine(93.6%) were observed. 4. In the analysis of QOL attached by cancer, combined treatment of western and oriental therapy(maintenance and improvement; 91.8%) was higher than traditional oriental cancer therapy(maintenance and improvement; 79.3%) 5. In the analysis of survival in patients with terminal cancer, above 6 months(46.3%), 12 months( 19.2%). 6. In the analysis of antitumor effects, combined treatment of western and oriental therapy(maintenance 71.6% improvement 12.8%) was higher than traditional oriental therapy (maintenance 66.7% improvement 9.5%). 7. In the analysis of curative evaluation, combined treatment of western and oriental therapy(maintenance 40.4% improvement 41.8%) was higher than traditional oriental therapy (maintenance 23.8% improvement 46.1%). 8. In the analysis of IL-12 and IFN-γ attached by cancer, increasing of IL-12(32.3%), IFN-γ(41.5%) were observed. From the above results, it is suggested that Hangamdan has significant effects of antitumor and immune activity, also could be usefully applied for cancer patients by combination with western therapy or alone.

冬蟲夏草의 抗轉移와 免疫增進에 關한 硏究

최우진,유화승,이용연,서상훈,조정효,이연월,손창규,조종관 대전대학교 한방병원 2000 惠和醫學 Vol.9 No.2

This experimental study was carried out to evaluate the effects of Cordiceps sinensis on the antimetastasis and immune activity. In order to investigate the effect of Cordiceps sinensis, the followings were performed; Cytotoxicity, inhibition of MMP-2 & MMP-9 gene expression, fraction of CD4+, CD8+, CD19+ in splenic cell, the moprphological change of splenic cells, gene expression of IL-12(p35), IL-12(p40), IFN-?? and splenic cell proliferation by CS-E. The results were obtained as follows. 1. CS-E did not present cytotoxic effect on L+14, B16-F10 melanoma cells and HMCB. 2. CS-E inhibited MMP-2 and MMP-9 gene expression more effectively compared with control group. 3. CS-E inhibited invasion of B16-F10 melanoma cells more effectively compared with control group. 4. CS-E helped CD4+, CD8+, CD19+ expression more effectively compared with control group. 5. CS-E activated phagocytic cells in spleen more effectively compared with control group. 6. CS-E helped IL-12(p35), IL-12(p40), IFN-?? gene expression in splenic cell more effectively compared with control group. 7. CS-E activated splenic cell proliferation more effectively compared with control group. From above findings, it is suggested that CS-E is able to inhibit metastasis of cancer and activate immune response system.