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Hervás Marta Soriano,Játiva-Porcar Rosa,Robles-Hernández Daniel,Rubert Anna Serra,Segarra Blanca,Oliva Cristina,Escrig Javier,Llueca José Antonio 대한마취통증의학회 2021 Korean Journal of Anesthesiology Vol.74 No.1
BackgroundCytoreductive surgery was developed as a treatment for peritoneal carcinomatosis. However, this surgery is associated with important complications. The present study aimed to assess the relationship between lactacidemia and the rate of associated complications during the immediate postoperative period in the intensive care unit (ICU) in patients undergoing cytoreductive surgery.MethodsThis was a retrospective observational study. A total of 57 patients underwent cytoreductive surgery. All patients were admitted to the ICU immediately after the surgery. Data on lactic acid levels at the time of admission and discharge from the ICU were collected. Postsurgical complications that occurred during the ICU stay were recorded according to failure-to-rescue analysis and their severity stratified according to the Clavien-Dindo classification.ResultsThe lactic acid levels at admission to the ICU were significantly higher in patients who developed complications, with an almost tripled unadjusted relative risk (2.9, 95% CI: 1.6, 5.3), than in those who did not develop complications for the lactacidemia threshold established in the cumulative sum curve graphs. After adjustment for confounding effects, the relative risk became even higher (3.1, 95% CI: 1.8, 3.6). Lactic acid levels were still significantly higher in this group at the time of discharge from the ICU.ConclusionsSerum lactate level is a risk factor for postoperative complications in patients undergoing cytoreductive surgery for peritoneal carcinomatosis. This study suggests that the risk of developing severe complications almost triples with a lactic acid level of 2.5 mmol/L or higher at the time of admission in the ICU.
Serra, A.B.,Serra, S.D.,Serra, F.B.,Domingo, I.J.,Cruz, L.C.,Fujihara, T. Asian Australasian Association of Animal Productio 1995 Animal Bioscience Vol.8 No.2
This study was conducted 1) to compare the nutrient content and mineral composition of the Philoppine indigenous sheep and goats diets when grazed in common pasture during rainy season, 2) to determine the influence of sampling methods on nutrient content and mineral composition of upland (UP) and lowland (LP) native pastures, and 3) to compare these two pasture types in terms of nutrient and mineral composition. Experiment 1 used sis esophageally fistulated animals, three each for sheep and goats. Weekly extrusa collection was done for a period of three months. Experiment 2 was conducted in UP and LP; these were sampled thrice by three methods, plucking, clipping and use of three esophageally fistulated sheep. Results of Experiment 1 indicated that the diets of sheep were greater in crude protein(CP; p < 0.01) and ether extract(EE; p < 0.05) but lower in crude fiber (CF) and acid detergent lignin (ADL; p < 0.05) than that of goat diets. All other nutrient fractions including mineral composition were not significantly different from each other. Significant findings of Experiment 2 were: CP content of UP was in the order fistulated > plucked > clipped (p < 0.05); CP content of LP was greater (p <0 .05) in fistulated and plucked samples; and ash content was greater (p < 0.05) in fistulated samples of both pastures. The CP of UP was different (p < 0.05) from each sampling method but the CP of LP and ADL of both pastures were greater (p < 0.05) in clipped samples. Most minerals either macro or microminerals were greater in fistulated samples of both pastures. Pooled data of the two pastures showed that LP had better nutrient characteristics and greater mineral composition. Based from this study, there were few differences between the diets of indigenous sheep and goats when grazed in common pasture. Also, sampling methods influenced the nutrient composition of indigenous sheep diets.
AmpFlSTR<sup>(</sup>R) MiniFiler(TM) PCR amplification kit: The new miniSTR multiplex kit
Andrade, L.,Bento, A.M.,Serra, A.,Carvalho, M.,Gamero, J.J.,Oliveira, C.,Batista, L.,Lopes, V.,Balsa, F.,Corte-Real, F.,Anjos, M.J. Elsevier 2008 Forensic science international. Genetics. Suppleme Vol.1 No.1
The AmpFlSTR<SUP>(</SUP>R) MiniFiler(TM) PCR amplification kit (Applied Biosystems), a new available 8-miniSTR and the sex determining marker Amelogenin multiplex, includes the most common problematic loci (above 200bp) of the AmpFlSTR<SUP>(</SUP>R) Identifiler(TM) PCR amplification kit: FGA, D21S11, D18S51, D13S317, D7S820, D16S539, CSF1PO and D2S1338. Several casework samples with different DNA contents were tested. Results allowed to complete partial Identifiler(TM) profiles and additional information was achieved in low copy number (LCN) samples, revealing that this miniSTR kit can improve identification of compromised samples.
Sousa A. S.,Serra J.,Estevens C.,Costa R.,Ribeiro A. J. 한국약제학회 2023 Journal of Pharmaceutical Investigation Vol.53 No.2
Background Oral extended release (ER) delivery systems have quickly gained increasing importance because of their ability to maintain drug levels in the blood more consistently, reducing side effects and improving patient compliance. The complexity of ER formulation leads to additional development challenges in the fulfilment of quality-related regulatory requirements. Despite their challenging properties, the potential of ER system formulation and process development can be better exploited by applying quality by design (QbD) approaches and advanced modeling techniques such as machine learning (ML). Area covered This review provides a comprehensive overview of QbD concepts applied to oral ER delivery systems, clarifying the impact of raw materials and process variables on critical quality attributes (CQAs). Moreover, data science coupled with ML algorithms is also elucidated in this article as a potential tool for predicting and optimizing ER formulation design and manufacturing processes. Expert opinion QbD, as a scientific and risk-based approach, provides a comprehensive understanding of oral ER drug delivery systems improving product quality and reducing postapproval changes. Enabling QbD with ML-driven pharmaceutical development can provide an opportunity to move toward risk mitigation for efficient ER tablet formulation and process development. However, there are some barriers to overcome in the way of adopting QbD concepts. The key issues are the lack of understanding and the gap between industries and regulatory authorities concerning the scientific principles and terms beyond QbD, which can create an obstacle during the approval process. Furthermore, it is generally believed that the resources and time invested in applying QbD tools are not cost-effective during constant and continuous improvement. Today, it is time to realize that a multidisciplinary understanding of the formulation and manufacturing process is as important as achieving the final result.
Chetty, R.,Gill, P.,Govender, D.,Bateman, A.,Chang, H.J.,Deshpande, V.,Driman, D.,Gomez, M.,Greywoode, G.,Jaynes, E.,Lee, C.S.,Locketz, M.,Rowsell, C.,Rullier, A.,Serra, S.,Shepherd, N.,Szentgyorgyi, W. B. Saunders Co ; Centrum Philadelphia 2012 Human pathology Vol.43 No.11
The aim of this study was to ascertain the level of concordance among gastrointestinal pathologists for regression grading in rectal cancers treated with neoadjuvant chemoradiation. Seventeen gastrointestinal pathologists participated using the Mandard, Dworak, and modified rectal cancer regression grading systems to grade 10 representative slides that were selected from 10 cases of rectal cancer treated with long-course neoadjuvant chemoradiation. The slides were scanned with a whole-slide scanner generating dynamic digitized images. The results showed very little concordance across the 3 grading systems, with κ values of 0.28, 0.35, and 0.38 for the Mandard, Dworak, and modified rectal cancer regression grading systems, respectively. In only 1 of 10 study cases was there unanimous grading concordance using the modified rectal cancer regression grading system. It was felt that these systems lacked precision and clarity for reproducible, accurate regression grading. The study concluded that there was a need for a simple, reproducible regression grading system with clear criteria, a cumulative or composite score taking into account all sections of the tumor bed that is sampled rather than the worst section (highest grade), and there should be a uniform method of sampling of these specimens.
A comparative study of salt tolerance parameters in 11 wild relatives of <i>Arabidopsis thaliana</i>
Orsini, Francesco,D'Urzo, Matilde Paino,Inan, Gunsu,Serra, Sara,Oh, Dong-Ha,Mickelbart, Michael V.,Consiglio, Federica,Li, Xia,Jeong, Jae Cheol,Yun, Dae-Jin,Bohnert, Hans J.,Bressan, Ray A.,Maggio, Al Oxford University Press 2010 Journal of experimental botany Vol.61 No.13
<P>Salinity is an abiotic stress that limits both yield and the expansion of agricultural crops to new areas. In the last 20 years our basic understanding of the mechanisms underlying plant tolerance and adaptation to saline environments has greatly improved owing to active development of advanced tools in molecular, genomics, and bioinformatics analyses. However, the full potential of investigative power has not been fully exploited, because the use of halophytes as model systems in plant salt tolerance research is largely neglected. The recent introduction of halophytic <I>Arabidopsis</I>-Relative Model Species (ARMS) has begun to compare and relate several unique genetic resources to the well-developed <I>Arabidopsis</I> model. In a search for candidates to begin to understand, through genetic analyses, the biological bases of salt tolerance, 11 wild relatives of <I>Arabidopsis thaliana</I> were compared: <I>Barbarea verna, Capsella bursa-pastoris, Hirschfeldia incana, Lepidium densiflorum, Malcolmia triloba, Lepidium virginicum, Descurainia pinnata, Sisymbrium officinale, Thellungiella parvula, Thellungiella salsuginea</I> (previously <I>T. halophila</I>)<I/>, and <I>Thlaspi arvense</I>. Among these species, highly salt-tolerant (<I>L. densiflorum</I> and <I>L. virginicum</I>) and moderately salt-tolerant (<I>M. triloba</I> and <I>H. incana</I>) species were identified. Only <I>T. parvula</I> revealed a true halophytic habitus, comparable to the better studied <I>Thellungiella salsuginea</I>. Major differences in growth, water transport properties, and ion accumulation are observed and discussed to describe the distinctive traits and physiological responses that can now be studied genetically in salt stress research.</P>