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불안정 애착과 관계중독의 관계: 자기통제력에 의해 조절된 내면화된 수치심의 매개효과
홍세림 ( Hong Serim ),장유진 ( Jang Yoojin ) 한국청소년학회 2023 청소년학연구 Vol.30 No.5
본 연구에서는 성인들의 불안정 애착과 관계중독의 관계에서 내면화된 수치심의 매개효과를 확인하고, 이러한 매개효과가 자기통제력 수준에 따라 변화하는지 확인하고자 하였다. 전국 20대~50대 성인 307명을 대상으로 자기 보고식 설문을 통해 자료를 수집하였고 수집된 자료는 SPSS 26.0과 PROCESS Macro를 활용하여 분석하였다. 주요한 연구결과를 요약하면 다음과 같다. 첫째, 애착불안이 높을수록 관계중독 수준이 높은 것으로 나타났으며, 애착회피는 관계중독과 유의한 관련성을 보이지 않았다. 둘째, 애착불안과 관계중독의 관계에서 내면화된 수치심이 부분 매개하는 것으로 나타났다. 셋째, 내면화된 수치심과 관계중독의 관계에서 자기통제력의 조절효과가 유의하였다. 넷째, 애착불안이 내면화된 수치심을 거쳐 관계중독에 미치는 간접효과가 자기통제력의 수준에 따라 달라지는 것으로 나타나 조절된 매개효과가 유의하였다. 연구 결과를 바탕으로 청소년 상담에서의 시사점을 제시하였으며, 연구의 제한점을 토대로 후속연구의 방향을 제언하였다. This study examined the mediating effects of internalized shame between insecure attachment and relation addiction among adults and whether these mediating effects would vary depending on levels of self-control. Data were collected using the self-report survey from 307 adults aged between their 20s to 50s. The collected data were analyzed using SPSS 26.0 and PROCESS Macro. The main results are as follows. First, an anxious attachment was positively related to relationship addiction, but the avoidant attachment was not significantly correlated with relationship addiction. Second, internalized shame partially mediated the relationship between anxious attachment and relationship addiction. Third, self-control moderated the relationship between internalized shame and relationship addiction. Fourth, the indirect effect of anxious attachment on relationship addiction via internalized shame varied depending on levels of self-control, indicating that the moderated mediation effect was significant. Based on the findings, implications for counseling adolescents were presented, as well as directions for future studies along with the limitations of this study.
소와 돼지 도축장 도체 및 환경에서 분리된 병원성대장균 분포 및 특성조사
홍세림 ( Serim Hong ),강혜정 ( Hye Jeong Kang ),문진산 ( Jin-san Moon ),윤순식 ( Soon-seek Yoon ),김하영 ( Ha-young Kim ) 한국동물위생학회 2022 韓國家畜衛生學會誌 Vol.45 No.3
We investigated the virulence genes, O-serotypes, antimicrobial resistance of pathogenic E. coli isolated from carcasses (n=455) and environmental (n=372) samples of 11 cattle and 12 pig slaughterhouses from December 2020 to December 2021. E. coli were isolated from nine carcasses (2.0%), three slaughter facilities (1.4%), two utensils (2.7%) and three abattoir workers (3.5%) from four cattle and four pig slaughterhouses. Among all isolates, 13 STEC (76.5%) were identified, followed by four EPEC (23.5%). As a result of the antibiotic susceptibility test, all isolates were resistant to at least one antimicrobial, of which 70.6% isolates showed multidrug resistance patterns. The serotypes were diverse in pigs compared to cattle, with serotypes O18, O66, O109 in cattle and O9, O76, O85, O100, O153, and O159 in pigs. In a single cattle slaughterhouse, eight STEC O66 were isolated from various types of sample (4 slaughter animal surfaces, 3 gloves, and 1 knife) with two antimicrobial resistance patterns (CHL-FIS-STR and CHL-FIS). Those two types of strain were suspected crosscontamination from utensils to slaughter animal surfaces. These results showed that pathogenic E. coli were detected in carcasses and various environmental samples in cattle and pig slaughterhouses. Nationwide monitoring and hygiene management are required to prevent cross-contamination of STEC isolate slaughterhouses.
Ki-Won Lee,Serim Hong,Md. Atikur Rahman,Hee Chung Ji,Joon-Yung Cha,Chris Stephen Jones,Daeyoung Son,Sang-Hoon Lee 한국생물공학회 2019 Biotechnology and Bioprocess Engineering Vol.24 No.3
The glutathione S-transferases (GSTs) are encoded by a large gene family and well conserved in all living organisms; however they have evolved and are classified clearly according to each kingdom. GSTs are a dimeric protein that has been reported to maintain redox homeostasis in cells, and to protect organisms against oxidative damage. Recently, we isolated a GST coding gene from stress-treated teff grass (Eragrostis tef) and identified it as a plant-specific phi class GST (EtGSTF1) possessing conserved phi class-specific GST N- and Cterminal domains, GSH binding site, substrate binding pocket, and dimer interface. We found that overexpression of plant-specific phi class EtGSTF1 confers diverse abiotic stress tolerances including salt, osmotic, and heat stresses in E. coli which does not possess phi class GSTs. In addition, EtGSTF1 expression helps the E. coli cells tolerate arsenic (As)-induced cell toxicity. Collectively, although plantae and prokaryotae have differentiated a few billions of years ago, the plant-specific phi class EtGSTF1 could protect prokaryotic organisms by detoxification of molecules under diverse abiotic stresses.
박나영(Nayoung Park),민세림(Serim Min),손영후(Young Hu Shon),남진현(Jin Hyun Nam),권순홍(Sun-Hong Kwon) 대한약학회 2021 약학회지 Vol.65 No.6
Unapproved investigational drugs have substantial uncertainty in terms of efficacy and safety. The compassionate use of investigational drugs, nevertheless, provides a patient with a serious disease or life-threatening condition a pathway to access unauthorized medications. This has gained significant traction during the Coronavirus 2019 disease pandemic. We review the laws and regulations of programs in the United States of America, Australia, the United Kingdom, and South Korea, where such programs are currently in effect, specifically on the following aspects: regulations, requirements, eligible patients, charges, and patient safety plans. Additionally, we investigated therapeutic-approval cases in South Korea from January 2016 to March 2021.
젖소 유방염에서 분리한 Streptococcus 종의 분포 및 항생제 내성 분석
강혜정 ( Hye Jeong Kang ),홍세림 ( Serim Hong ),박다솜 ( Dasom Park ),김하영 ( Ha-young Kim ),문진산 ( Jin-san Moon ) 한국동물위생학회 2022 韓國家畜衛生學會誌 Vol.45 No.3
Streptococcus is one of the major pathogen groups inducing bovine mastitis. The aim of this study was to investigate the antimicrobial resistance patterns of Streptococcus species isolated from bovine mastitis milk samples in Korea from 2016 to 2021. In total, 181 (10.3%) Streptococcal isolates were collected from 1,761 quarter milk samples at 122 farms; S. uberis 39.2% (n=71), S. dysgalactiae 29.3% (n=53), S. equinus 9.9% (n=18), S. suis 6.1% (n=11), S. parauberis 4.4% (n=8), S. lutetiensis 3.9% (n=7), others 7.2% (n=13). However, S. agalactiae was not isolated. The isolates showed the highest resistance rate to tetracycline (55.2%) followed by erythromycin (45.3%) and pirlimycin (36.5%). In contrast, all isolates were susceptible to ceftiofur, cephalothin, penicillin/novobiocin, and only single S. equinus isolate was resistant to both ampicillin and penicillin. Of 181 isolates, 64 (35.4%) were multidrug resistance (MDR). The resistance to pirlimycin of S. uberis (73.2%) was much higher than that of other species (0∼36.4%). All S. suis isolates were resistance to tetracycline. S. dysgalactiae showed lower resistance to erythromycin, pirlimycin and tetracycline than S. uberis and S. suis. The rate of MDR was relatively higher among S. uberis (73.2%) than among S. suis (36.4%), S. dysgalactiae (15.1%), others (0%). In conclusion, antimicrobial resistance in Streptococcus spp. should be regularly examined for appropriate therapies because the resistance patterns were various among the individual species.
젖소 유방염에서 분리한 Pseudomonas spp.의 분포 및 항생제 내성 비교
강혜정 ( Hye Jeong Kang ),김하영 ( Ha-young Kim ),홍세림 ( Serim Hong ),박다솜 ( Dasom Park ),윤순식 ( Soon-seek Yoon ),문진산 ( Jin-san Moon ) 한국동물위생학회 2021 韓國家畜衛生學會誌 Vol.44 No.3
This study was aimed to investigate the prevalence and antimicrobial resistance of Pseudomonas spp. isolated from bovine mastitis milk samples. A total of 50 (4.9%) Pseudomonas spp. was isolated from 1,023 samples, those collected between 2018 and 2021, derived from 110 dairy farms. The prevalence of the identified species of Pseudomonas isolates was as follows; P. aeruginosa (70.0%), P. fluorescens (14.0%), P. putida (10.0%), P. fragi (4.0%), and P. chlororaphis (2.0%). Most of somatic cell counts in the quarter milk carrying Pseudomonas spp. were less than 3,000,000 cell/ml (90.0%). The isolates of Pseudomonas spp. showed high susceptibility to cefepime (98.0%), ciprofloxacin (98.0%), ceftazidime (96.0%), and colistin (96.0%). The rate of antibiotic resistance in the isolates was highest to ceftiofur (92.0%), followed by the resistance rate to chloramphenicol (86.0%) and trimethoprim/ sulphamethoxazole (80.0%). In addition, there is a remarkable difference in antimicrobial resistance pattern among Pseudomonas species. P. aeruginosa and P. putida showed a similar resistance pattern, whereas P. fluorescens showed exceptionally lower resistance to trimethoprim/sulphamethoxazole and chloramphenicol than that of the other species. This study showed that prevalence of Pseudomonas spp. other than P. aeruginosa were 30.0% in bovine mastitis milk, and the occurrence rate of antibiotic resistance were similar or higher level, compared with the previous reports on the mastitis- derived Pseudomonas spp. isolated in Korea.
Park Hae-Young,Kwon Jin-Won,Kim Hye-Lin,Kwon Sun-Hong,Nam Jin Hyun,Min Serim,Oh In-Sun,Bea Sungho,Choi Sun Ha 대한의학회 2023 Journal of Korean medical science Vol.38 No.21
Background: Regimens for the treatment of multidrug-resistant tuberculosis (MDR-TB) have been changed from injectable-containing regimens to all-oral regimens. The economic effectiveness of new all-oral regimens compared with conventional injectable-containing regimens was scarcely evaluated. This study was conducted to compare the cost-effectiveness between all-oral longer-course regimens (the oral regimen group) and conventional injectablecontaining regimens (the control group) to treat newly diagnosed MDR-TB patients. Methods: A health economic analysis over lifetime horizon (20 years) from the perspective of the healthcare system in Korea was conducted. We developed a combined simulation model of a decision tree model (initial two years) and two Markov models (remaining 18 years, sixmonth cycle length) to calculate the incremental cost-effectiveness ratio (ICER) between the two groups. The transition probabilities and cost in each cycle were assumed based on the published data and the analysis of health big data that combined country-level claims data and TB registry in 2013–2018. Results: The oral regimen group was assumed to spend 20,778 USD more and lived 1.093 years or 1.056 quality-adjusted life year (QALY) longer than the control group. The ICER of the base case was calculated to be 19,007 USD/life year gained and 19,674 USD/QALY. The results of sensitivity analyses showed that base case results were very robust and stable, and the oral regimen was cost-effective with a 100% probability for a willingness to pay more than 21,250 USD/QALY. Conclusion: This study confirmed that the new all-oral longer regimens for the treatment of MDR-TB were cost-effective in replacing conventional injectable-containing regimens.