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호중구 감소증을 유도한 마우스에서의 유전자 재조합 인과립구 콜로니자극인자의 효과
조명행(Myung Haing Cho),유아선(Ah Sun Yu),방명주(Ming Zhu Fang),곽형일(Hyung Il Kwak),성하정(Ha Jung Seong),강관엽(Koan Yeob Kang),최승진(Seung Jin Choi),정경환(Kyung Hwan Jung),박두홍(Doo Hong Park),안길환(Gil Hwan Ahn) 한국응용약물학회 1998 Biomolecules & Therapeutics(구 응용약물학회지) Vol.6 No.2
Administration of 3 type KGCs [recombinant human granulocyte colony-stimulating factor (rhGCSF)] to mice with cyclophosphamide (CPA)-induced neutropenia for 4 consecutive days from the day after the CPA dosing (100 mg/kg) resulted in a dose dependent increase in the peripheral blood neutrophil count 6 hours after the final KGC injection. Within the KGC dose range of 0.1 to 40 ㎍ per mouse per day, there was a sigmoidal relationship between the logarithm of the dose and the peripheral blood neutrophil count (relative value for neutrophil count of the basal dose) in the treated mice. The sigmoidal relationship of test KGC preparations shows that there is a saturation point in terms of efficacy. Compared with effect of KGC-Orange, Green, and Blue, KGC-Orange recovers neutrophils more effectively than the others do.
Establishment of a bone-specific col10a1:GFP transgenic zebrafish
Kim, Yong-Il,Lee, Suman,Jung, Seung-Hyun,Kim, Hyun-Taek,Choi, Jung-Hwa,Lee, Mi-Sun,You, Kwan-Hee,Yeo, Sang-Yeob,Yoo, Kyeong-Won,Kwak, SeongAe,Lee, Joon No,Park, Raekil,Choe, Seong-Kyu,Kim, Cheol-Hee Springer-Verlag 2013 Molecules and cells Vol.36 No.2