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Park, Jung-Hoon,Kang, Woo Seok,Kim, Kun Yung,Kang, Byung-Chul,Park, Jun Woo,Kim, Min Tae,Bekheet, Nadar G.,Hwang, Seung Jun,Choi, Joonmyeong,Cho, Kyu-Jin,Park, Hong Ju,Song, Ho-Young Elsevier 2018 Journal of vascular and interventional radiology Vol.29 No.8
<P><B>Abstract</B></P> <P><B>Purpose</B></P> <P>To investigate the technical feasibility of stent placement in the cartilaginous portion of the Eustachian tube (ET).</P> <P><B>Materials and Methods</B></P> <P>Twelve ETs of 6 cadavers were used. Two different-sized stents were placed on either the right (2.5 mm in diameter) or left (3.5 mm in diameter) side of the ET. The procedural feasibility was assessed by subtraction Eustachian tubography, computed tomography before and after the procedure, and fluoroscopic and endoscopic images. The stent location, inner luminal diameter of the stented ET, radiation dose, procedural time, and fluoroscopy time were analyzed.</P> <P><B>Results</B></P> <P>Stent placement was successful in 11 of 12 cadaveric specimens without procedure-related complications. In the 1 specimen, the balloon catheter with crimped stent was passed into the bony canal of the ET without any resistance. The distal end of the stent was located in the middle ear cavity. Stents were located within the cartilaginous portion of the ET (n = 1), the proximal tip bridging the nasopharyngeal orifice of the ET (n = 5), or the proximal end of the stent protruded from the tubal orifice (n = 5). The mean luminal diameter in the outer segment was significantly smaller than in the middle (<I>P</I> < .001) and inner (<I>P</I> < .001) segments. The mean procedure time was 128 ± 37 seconds. The mean radiation dose and fluoroscopy time of each cadaver were 3235.4 ± 864.8 cGy/cm<SUP>2</SUP> and 139 ± 49 seconds, respectively.</P> <P><B>Conclusions</B></P> <P>Stent placement of the ET under endoscopic and fluoroscopic guidance is technically feasible in a human cadaver model.</P>
Insect Juvenile Hormone Mimics from Plant Essential Oils
Kyu baik Ha,Dong Hwan Park,Seok-Hee Lee,Jong Hoon Kim,Ying Fang,Min Gu Park,Ra Mi Woo,Woo Jin Kim,Il-Kwon Park,Jae Young Choi,Yeon Ho Je 한국응용곤충학회 2016 한국응용곤충학회 학술대회논문집 Vol.2016 No.10
Insect growth regulators (IGRs) are attractive pest control agents due to their high target specificity and relative safety to the environment. Recently, plants have been shown to synthesize IGRs that affect the insect juvenile hormone (JH) as a part of their defense mechanisms. We identified several JH agonists (JHAs) and antagonists (JHANs) from plant essential oil compounds using a yeast two-hybrid system transformed with the Aedes aegypti JH receptor as a reporter system. They showed high mosquitocidal activities with relatively low LC50 values and caused retardation of ovarian development in female mosquitoes. While the JHAs increased the expression of JH-induced gene, the JHANs caused reduction in the expression of the same gene. The compounds identified in this study could provide insights on the plant-insect interactions and may be useful for the development of novel IGR insecticides.
Endoscopic disconnection of hypothalamic astrocytoma causing gelastic epilepsy
Park, Young Seok,Lee, Yun Ho,Shim, Kyu-Won,Kim, Dong-Seok,Lee, Joon Soo,Kim, Heung Dong Journal of Neurosurgery Publishing Group 2009 Journal of neurosurgery. Pediatrics Vol.4 No.2
<P>The authors report on a case of juvenile pilocytic astrocytoma (JPA) and concomitant hypothalamic hamartoma (HH) with gelastic epilepsy that was successfully treated with endoscopic disconnection. This 6-year-old girl presented with prolonged, medically intractable gelastic seizures that were often followed by generalized tonic seizures. An enhancing, low-grade hypothalamic tumor was identified on MR images obtained when she was 11 months old, but no surgical intervention was attempted at that time apart from bur hole drainage of a chronic subdural hemorrhage. In the first surgery, performed when she was 6 years of age, the authors attempted disconnection and tumor sampling; the lesion was revealed to be a JPA. A second endoscopic disconnection was performed 1 year later to improve seizure control and obtain a pathological specimen from the nonenhancing contralateral side. The pathological results after the second surgery revealed that the enhancing mass was a spontaneously regressing JPA and the contralateral nonenhancing mass was an HH. The HH was found as latent tumor and the JPA was the mass causing gelastic epilepsy. To the authors' knowledge, this is the first report of a patient with a spontaneously regressing JPA and concomitant HH, both of which were treated by endoscopic disconnection.</P>
Kyu-Tek Park,Sang-Mi Lee,Jun-Seok Lee 한국응용곤충학회 2000 INSECTA KOREANA Vol.17 No.3
대만산 뿔나방과의 재정리를 통해 10 미기록종 및 1신종이 발견되어 이를 보고하며, 1신종, Faristenia obliqua Park, sp. nov.를 생식기 도해와 함께 기재, 발표한다. Ten species of Gelechiiidae are reported for the first time from Taiwan, and a new species, Faristenia oblique Park, sp. nov. is described, with illustrations of its male and female genitalia. It is confirmed that the record of Parastenolechia claustrifera Meyrick from Korea by Park(1993) was due to a misidentification.
Contorted polycyclic aromatic hydrocarbon: promising Li insertion organic anode
Park, Jaehyun,Lee, Cheol Woo,Joo, Se Hun,Park, Ju Hyun,Hwang, Chihyun,Song, Hyun-Kon,Park, Young Seok,Kwak, Sang Kyu,Ahn, Seokhoon,Kang, Seok Ju The Royal Society of Chemistry 2018 Journal of Materials Chemistry A Vol.6 No.26
<P>Enhancing the performance of carbon-based anode materials in Li-ion battery (LIB) systems is of considerable interest in terms of next-generation LIB host electrodes, because the unique reversible intercalation-de-intercalation process of such materials ultimately facilitates increases in LIB performance and longevity. This study explored the potential of a new class of carbon-based contorted hexabenzocoronene (c-HBC) as an anode material for high-performance LIB systems. The exploitation of the polymorphic crystalline nature of c-HBC resulted in successful development of a LIB anode based on a newly found crystal phase of trigonal <I>R</I>3̄ by solvent and subsequent thermal annealing. Our in-depth analysis based on cross-sectional transmission electron microscopy, grazing incidence X-ray diffraction, and computational investigation revealed further advantages of using contorted molecules in LIB systems. For instance, the resulting electrochemical characteristics using half-cell architecture clearly reflected single-stage Li insertion behavior associated with the large interspacing and short diffusion length of c-HBC molecule during the discharging process. In addition, the battery exhibited excellent rate capability and cycle endurance, highlighting the suitability of c-HBC as an anode material for high-performance LIBs.</P>
Park, Seung-Taeck,Park, Yang-Kyu,Park, Jae-Hwang,Cho, Kwang-Ho,Ryu, Do-Gon,Jeon, Byung-Hoon,Shin, Min-Kyo,Han, Du-Seok,Cho, Nam-Su,Shin, Dong-Min Kyung Hee Oriental Medicine Research Center 2000 International journal of oriental medicine Vol.1 No.1
Effects of Rhizoma gastrodiae on glucose oxidase-induced neurotoxicity was investigated in cultured newborn mouse spinal dorsal root ganglion(DRG) neurons that were treated in the media with or without glucose oxidase. In addition, the protective effect of Rhizoma gastrodiae extract against glucose oxidase-induced neurotoxicity was examined. Cytotoxic values were expressed as a percentage of number of living cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. In this paper, exposure of neurons to glucose oxidase resulted in a significant call death in a dose- and time-dependent manners in DRG neuron cultures. The decrease in cell viability induced by the glucose oxidase was blocked by Rhizoma gastrodiae extract. These results indicate that the neuroprotective effect of Rhizoma gastrodiae extract against glucose oxidase-induced neurotoxicity may result from a prevention or attenuation of oxidative damage induced by glucose oxidase.
Park, Young-Seok,Kim, Sungtae,Oh, Seung-Hee,Park, Hee-Jung,Lee, Sophia,Kim, Tae-Il,Lee, Young-Kyu,Heo, Min-Suk Korean Academy of Oral and Maxillofacial Radiology 2014 Imaging Science in Dentistry Vol.44 No.2
Purpose: This study evaluated the efficacy of alveolar ridge preservation methods with and without primary wound closure and the relationship between histometric and micro-computed tomographic (CT) data. Materials and Methods: Porcine hydroxyapatite with polytetrafluoroethylene membrane was implanted into a canine extraction socket. The density of the total mineralized tissue, remaining hydroxyapatite, and new bone was analyzed by histometry and micro-CT. The statistical association between these methods was evaluated. Results: Histometry and micro-CT showed that the group which underwent alveolar preservation without primary wound closure had significantly higher new bone density than the group with primary wound closure (P<0.05). However, there was no significant association between the data from histometry and micro-CT analysis. Conclusion: These results suggest that alveolar ridge preservation without primary wound closure enhanced new bone formation more effectively than that with primary wound closure. Further investigation is needed with respect to the comparison of histometry and micro-CT analysis.
Park, Sun-Ji,Kim, Tae-Shin,Park, Choon-Keun,Lee, Sang-Hee,Kim, Jin-Man,Lee, Kyu-Sun,Lee, In-kyu,Park, Jeen-Woo,Lawson, Mark A,Lee, Dong-Seok Society for Endocrinology 2013 Journal of molecular endocrinology Vol.50 No.2
<P>Endoplasmic reticulum (ER) stress generally occurs in secretory cell types. It has been reported that Leydig cells, which produce testosterone in response to human chorionic gonadotropin (hCG), express key steroidogenic enzymes for the regulation of testosterone synthesis. In this study, we analyzed whether hCG induces ER stress via three unfolded protein response (UPR) pathways in mouse Leydig tumor (mLTC-1) cells and the testis. Treatment with hCG induced ER stress in mLTC-1 cells via the ATF6, IRE1a/XBP1, and eIF2α/GADD34/ATF4 UPR pathways, and transient expression of 50 kDa protein activating transcription factor 6 (p50ATF6) reduced the expression level of steroidogenic 3β-hydroxysteroid dehydrogenase △5-△4-isomerase (3β-HSD) enzyme. In an <I>in vivo</I> model, high-level hCG treatment induced expression of p50ATF6 while that of steroidogenic enzymes, especially 3β-HSD, 17α-hydroxylase/C17–20 lyase (CYP17), and 17β-hydrozysteroid dehydrogenase (17β-HSD), was reduced. Expression levels of steroidogenic enzymes were restored by the ER stress inhibitor tauroursodeoxycholic acid (TUDCA). Furthermore, lentivirus-mediated transient expression of p50ATF6 reduced the expression level of 3β-HSD in the testis. Protein expression levels of phospho-JNK, CHOP, and cleaved caspases-12 and -3 as markers of ER stress-mediated apoptosis markedly increased in response to high-level hCG treatment in mLTC-1 cells and the testis. Based on transmission electron microscopy and H&E staining of the testis, it was shown that abnormal ER morphology and destruction of testicular histology induced by high-level hCG treatment were reversed by the addition of TUDCA. These findings suggest that hCG-induced ER stress plays important roles in steroidogenic enzyme expression via modulation of the ATF6 pathway as well as ER stress-mediated apoptosis in Leydig cells.</P>
A Case of Immunoglobulin A Nephropathy in a Patient with Kimura's Disease
Park, Hye Jung,Kim, Jae Kyung,Kim, Hyun Ju,Park, Kwan-Kyu,Bae, Yoon Sung,Lee, Yong Kyu,Kim, Beom Seok Yeungnam University College of Medicine 2013 Yeungnam University Journal of Medicine Vol.30 No.2
Kimura's disease is an angiolymphoid-proliferative disorder that manifests with benign subcutaneous swelling predominantly in the head and the neck. Kidney involvement, including proteinuria, occurs in 12-16% of patients with the disease, and 60-78% of such cases is nephrotic syndrome. Reported etiologies of nephrotic syndrome in Kimura's disease include membranous glomerulonephritis, mesangial proliferative glomerulonephritis, minimal-change disease, focal segmental glomerulosclerosis, diffuse proliferative glomerulonephritis and immunoglobulin A (IgA) nephropathy. There have been only two case reports of IgA nephropathy in Kimura's disease, in 1998. In this report, we present a third case of IgA nephropathy associated with Kimura's disease.