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Luteolin inhibits H2O2-induced cellular senescence via modulation of SIRT1 and p53
Ri Zhe Zhu Bing Si Li Shang Shang Gao Jae Ho Seo Byung-Min Choi 대한생리학회-대한약리학회 2021 The Korean Journal of Physiology & Pharmacology Vol.25 No.4
Luteolin, a sort of flavonoid, has been reported to be involved in neu-roprotective function via suppression of neuroinflammation. In this study, we in-vestigated the protective effect of luteolin against oxidative stress-induced cellular senescence and its molecular mechanism using hydrogen peroxide (H2O2)-induced cellular senescence model in House Ear Institute-Organ of Corti 1 cells (HEI-OC1). Our results showed that luteolin attenuated senescent phenotypes including alterations of morphology, cell proliferation, senescence-associated β-galactosidase expression, DNA damage, as well as related molecules expression such as p53 and p21 in the oxidant challenged model. Interestingly, we found that luteolin induces expression of sirtuin 1 in dose- and time-dependent manners and it has protective role against H2O2-induced cellular senescence by upregulation of sirtuin 1 (SIRT1). In contrast, the inhibitory effect of luteolin on cellular senescence under oxidative stress was abolished by silencing of SIRT1. This study indicates that luteolin effectively protects against oxidative stress-induced cellular senescence through p53 and SIRT1. These results suggest that luteolin possesses therapeutic potentials against age-related hearing loss that are induced by oxidative stress.
Seo Ri Kim,김익수,In Seon Kim 한국응용생명화학회 2009 Journal of Applied Biological Chemistry (J. Appl. Vol.52 No.2
Green peach aphid, Myzus persicae, is one of major pests attacking greenhouse pepper plants in Korea. We examined a pyrethrum emulsion for the control of M. persicae. The emulsion was prepared by blending natural pyrethrum extracts with food-acceptable components. The emulsion produced a clear aqueous solution when diluted in water. Laboratory evaluation showed an average 80% mortality of 2nd-instar nymphs after treatment at 100 mg/L natural pyrethrum. The aphid mortality data were a dose-response relationship for the emulsion. Field trials in two greenhouses showed aphid mortalities from 59.6 to 100% with 100 mg/L natural pyrethrum. No significant differences in aphid mortality between the two greenhouses were observed. This study shows that it is possible to prepare a one-phase clear emulsion of natural pyrethrum using foodacceptable components to control M. persicae. Pesticide formulations using food-acceptable components are suggested to play a role in protecting the public and environment from potential threats of botanical pesticides.
Cellulose-based Nanocrystals: Sources and Applications via Agricultural Byproducts
Seo, Yu-Ri,Kim, Jin-Woo,Hoon, Seonwoo,Kim, Jangho,Chung, Jong Hoon,Lim, Ki-Taek Korean Society for Agricultural Machinery 2018 바이오시스템공학 Vol.43 No.1
Purpose: Cellulose nanocrystals (CNCs) are natural polymers that have been promoted as a next generation of new, sustainable materials. CNCs are invaluable as reinforcing materials for composites because they can impart improved mechanical, chemical, and thermal properties and they are biodegradable. The purpose of this review is to provide researchers with information that can assist in the application of CNCs extracted from waste agricultural byproducts (e.g. rice husks, corncobs, pineapple leaves). Methods & Results: This paper presents the unique characteristics of CNCs based on agricultural byproducts, and lists processing methods for manufacturing CNCs from agricultural byproducts. Various mechanical treatments (microfluidization and homogenization) and chemical treatments (alkali treatment, bleaching and hydrolysis) can be performed in order to generate nanocellulose. CNC-based composite properties and various applications are also discussed. Conclusions: CNC-based composites from agricultural byproducts can be combined to meet end-use applications such as sensors, batteries, films, food packaging, and 3D printing by utilizing their properties. The review discusses applications in food engineering, biological engineering, and cellulose-based hydrogels.
Ri Ryu,Janghoo Seo,Yongseong Kim 보안공학연구지원센터 2014 International Journal of Smart Home Vol.8 No.6
This study was conducted to apply a phase change material (PCM) to the inner skin part of a double skin facade to positively utilize natural solar heat so that a double skin facade may not only counteract external environmental changes but also positively introduce external natural solar energy, highlighting the advantages of a double skin facade. However, PCM is currently used by impregnating to a wall or a board of a building. Studies on the determination of an appropriate PCM temperature according to the applications are only conducted with respect to a wall or a board. Applying a PCM to an inner part of a double skin facade system involves variables such as impregnation method and appropriate temperature. These are the properties of a PCM, which are important variables directly affecting the room temperature depending on the mixing ratios and applications targets. This study was conducted with respect to window surfaces having a direct impact on the inside and the outside of a building to select a double skin facade system having excellent energy-saving performance and determine a PCM temperature which is applicable to a double skin facade, verifying the indoor energy-saving effect depending on the application of a PCM to the inner part of a double skin facade.
Seo-Jeong Yim,Hye-Ji Seo,Yu-Ri Kim,Ji-Eun Oh 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Galactosemia, caused by galactose and metabolites generated during carbohydrate metabolism, is a rare genetic disease reported in Asian countries including Korea. There is lack of information about galactose content in safe foods and dietary guidelines. Therefore, a total of 10 subjects, including 5 parents of children under 12 years of age diagnosed with galactosemia, and 5 clinical experts participated in the Focus Group Interview. As a result, they stated lack of information on galactose content in food, components, and safe type of food. They also emphasized the development of appropriate dietary guidelines considering the domestic environment. In addition, the parents stated the difficulties due to conflicts by lack of understanding of diseases in family and others of society, which leads to social isolation. Thus, these problems need to be solved by establishing a database of trace amounts of galactose in food and social system. [This work was carried out with the support of ‘Cooperative Research Program for Agriculture Science and Technology Development (Project No. PJ 015600022021)’ in the Rural Development Administration, Republic of Korea.]
Seo, Nu-Ri,Ji, Min-Kyung,Park, Sang-Won,Lee, Kwangmin,Bae, Jung-Chan,Yun, Kwi-Dug,Park, Chan,Oh, Gye-Jeong,Kim, Ji-Hyun,Lim, Hyun-Pil American Scientific Publishers 2017 Journal of nanoscience and nanotechnology Vol.17 No.4
<P>Porphyromonas gingivalis (P. gingivalis) is one of main bacteria that adheres to the surface of dental implants and causes peri-implantitis. The purpose of this study was to observe the surface characteristics of titanium processed with either titanium nitride (TiN) sputter coating or plasma nitriding and to evaluate the subsequent adhesion of P. gingivalis. Specimens were divided into three groups: commercially pure (CP) titanium (control group), TiN sputter-coated titanium (group S), and plasma-nitrided titanium (group P). Surface characteristics such as roughness, morphology, and the formation of a thin TiN film or a nitriding layer were assessed. Adhesion of P. gingivalis in the three groups was determined by means of the crystal violet staining assay, and results were compared with one-way ANOVA, with post hoc comparison using Tukey's test (alpha = 0.05). Surface roughness values for the control group, group S, and group P were 0.08 +/- 0.02 mu m, 0.19 +/- 0.04 mu m, and 0.13 +/- 0.02 mu m, respectively. In group S, the TiN layer was 1.36 +/- 0.1 mu m thick, and nitrogen was detected on the surface of the specimens in group P, confirming formation of a nitrided layer. The level of adhesion in group P was significantly higher than that in the control group and in group S (p < 0.05), but there was no significant difference between the control group and group S. Within the limitations of this study, TiN sputter coating did not affect adhesion of P. gingivalis on the titanium surface, whereas adhesion was increased on the plasma-nitrided titanium surface.</P>