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RISS 인기검색어
- 검색키워드
- 저자 : Sen Ranjan (검색결과 6 건)
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Rho-dependent Transcription Termination: More Questions than Answers
Ranjan Sen,Jisha Chalissery,Sharmistha Banerjee,Irfan Bandey 한국미생물학회 2006 The journal of microbiology Vol.44 No.1
Escherichia coli protein Rho is required for the factor-dependent transcription termination by an RNA polymerase and is essential for the viability of the cell. It is a homohexameric protein that recognizes and binds preferably to C-rich sites in the transcribed RNA. Once bound to RNA, it utilizes RNA-dependent ATPase activity and subsequently ATPase-dependent helicase activity to unwind RNA-DNA hybrids and release RNA from a transcribing elongation complex. Studies over the past few decades have highlighted Rho as a molecule and have revealed much of its mechanistic properties. The recently solved crystal structure could explain many of its physiological functions in terms of its structure. Despite all these efforts, many of the fundamental questions pertaining to Rho recognition sites, differential ATPase activity in response to different RNAs, translocation of Rho along the nascent transcript, interactions with elongation complex and finally unwinding and release of RNA remain obscure. In the present review we have attempted to summarize ‘the knowns’ and ‘the unknowns’ of the Rho protein revealed by the recent developments in this field. An attempt has also been made to understand the physiology of Rho in the light of its phylogeny.
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Bikramaditya Swain,Ranjan Kumar Sahoo,Kamal Kumar Sen,Manoj Kumar G,Shylendra Singh Parihar,Roopak Dubey 대한해부학회 2020 Anatomy & Cell Biology Vol.53 No.1
Intrahepatic and extrahepatic anatomical knowledge is essential for pre procedural planning of liver transplantation, liver resection, complex biliary reconstruction and radiological biliary tree intervention. Indian data of biliary anatomy and its variation is scant in literature. The aim of our study is to find out the prevalence of common and uncommon pattern of biliary tree anatomy in magnetic resonance cholangiopancreatography (MRCP) in our population. A total of 1,038 cases of MRCP of population of Odisha were obtained from Picture Archiving and Communication System of the department and were reviewed by two senior radiologists for anatomical pattern and variations. The typical and most common pattern of right hepatic duct (RHD) branching was seen in 72.8% cases. The most common variant of RHD was trifurcation pattern of insertion of right anterior sectoral duct (RASD), right posterior sectoral duct and left hepatic duct (LHD) forming common hepatic duct (CHD) in 11.3% of cases. The common trunk of segment (SEG) II and III ducts joining the SEG IV duct was the most common LHD branching pattern in 90.3% of cases. The most common pattern of cystic duct was posterior insertion to middle third of CHD (42.8%). MRCP is the non-invasive imaging modality for demonstration of biliary duct morphology to prevent iatrogenic injury during hepatobiliary intervention and surgery.
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LABORATORY SIMULATION OF LIGHT SCATTERING FROM REGOLITH ANALOGUES: EFFECT OF POROSITY
KAR, AMRITAKSHA,DEB, SANJIB,SEN, A.K.,GUPTA, RANJAN The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2
The surfaces of most atmosphereless solar system objects are referred to as regolith, layers of loosely connected fragmentary debris, produced by meteorite impacts. Measurements of light scattered from such surfaces provides information about the composition and structure of the surface. A suitable way to characterize the scattering properties is to consider how the intensity and polarization of scattered light depends on the particle size, composition, porosity, roughness, wavelength of incident light and the geometry of observation. In the present work, the effect of porosity on bidirectional reflectance as a function of phase angle is studied for alumina powder with grain size of $0.3{\mu}m$ and olivine powder with grain size of $49{\mu}m$ at 543.5 nm. The optical constants of the alumina sample for each porosity were calculated with Maxwell Garnett effective medium theory. On using each of the optical constants of alumina sample in Mie theory with the Hapke model the variation of bidirectional reflectance is obtained as a function of phase angle with porosity as a parameter. Experimental reflectance data are in good agreement the model. For the olivine sample the effect of porosity is studied using Hapke (2008).
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Rho-dependent Transcription Termination: More Questions than Answers
Banerjee Sharmistha,Chalissery Jisha,Bandey Irfan,Sen Ranjan The Microbiological Society of Korea 2006 The journal of microbiology Vol.44 No.1
Escherichia coli protein Rho is required for the factor-dependent transcription termination by an RNA polymerase and is essential for the viability of the cell. It is a homohexameric protein that recognizes and binds preferably to C-rich sites in the transcribed RNA. Once bound to RNA, it utilizes RNA-dependent ATPase activity and subsequently ATPase-dependent helicase activity to unwind RNA-DNA hybrids and release RNA from a transcribing elongation complex. Studies over the past few decades have highlighted Rho as a molecule and have revealed much of its mechanistic properties. The recently solved crystal structure could explain many of its physiological functions in terms of its structure. Despite all these efforts, many of the fundamental questions pertaining to Rho recognition sites, differential ATPase activity in response to different RNAs, translocation of Rho along the nascent transcript, interactions with elongation complex and finally unwinding and release of RNA remain obscure. In the present review we have attempted to summarize 'the knowns' and 'the unknowns' of the Rho protein revealed by the recent developments in this field. An attempt has also been made to understand the physiology of Rho in the light of its phylogeny.
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Amrita Banerjee,Pradeep Kumar Das Mohapatra,Shilpee Pal,Keshab Chandra Mondal,Bikash Ranjan Pati,Arnab Sen,Tanmay Paul 셀메드 세포교정의약학회 2014 TANG Vol.4 No.1
Anthrax is the deadly disease for human being caused by Bacillus anthracis. Instantaneous research work on the mode of infection of the organism revealed that different proteases are involved in different steps of pathogenesis. Present study reports the in silico characterization and the detection of pathogenic proteases involved in anthrax infection through protein-protein interaction. A total of 13 acid, 9 neutral, and 1 alkaline protease of Bacillus anthracis were selected for analysing the physicochemical parameter, the protein superfamily and family search, multiple sequence alignment, phylogenetic tree construction, protein-protein interactions and motif finding. Among the 13 acid proteases, 10 were found as extracellular enzymes that interact with immune inhibitor A (InhA) and help the organism to cross the blood brain barrier during the process of infection. Multiple sequence alignment of above acid proteases revealed the position 368, 489, and 498-contained 100% conserved amino acids which could be used to deactivate the protease. Among the groups analyzed, only acid protease were found to interact with InhA, which indicated that metalloproteases of acid protease group have the capability to develop pathogenesis during B. anthracis infection. Deactivation of conserved amino acid position of germination protease can stop the sporulation and germination of B anthracis cell. The detailed interaction study of neutral and alkaline proteases could also be helpful to design the interaction network for the better understanding of anthrax disease.
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