http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Neoadjuvant Treatment for Gastric Cancer
Schuhmacher, Christoph,Reim, Daniel,Novotny, Alexander The Korean Gastric Cancer Association 2013 Journal of gastric cancer Vol.13 No.2
Surgery is still considered to be the mainstay for the treatment of localized gastric cancer with negative margins (R0-resection) and an adequate lymph-node-dissection (D2-lymphadenectomy). Unfortunately, most cases of gastric cancer are only diagnosed at an advanced stage due to frequent recurrences after primary resection in curative intent. In order to improve prognosis after curative resection, in the recent past, patients with locally advanced tumors were subjected to a pre-, peri-, or postoperative treatment. Interestingly, postoperative chemotherapy has significantly improved survival after gastric resection in Asia, adjuvant radiochemotherapy is favored in North America and perioperative chemotherapy is considered as a treatment of choice in Europe indicating region specific approach towards the treatment. Recently there has also been growing evidence of positive outcomes of neoadjuvant radiochemotherapy on patient survival. In the present article, we discuss the concepts of neoadjuvant treatment approach and provide recommendations to surgeons based on current evidence.
Neoadjuvant Treatment for Gastric Cancer
Christoph Schuhmacher,Daniel Reim,Alexander Novotny 대한위암학회 2013 Journal of gastric cancer Vol.13 No.2
Surgery is still considered to be the mainstay for the treatment of localized gastric cancer with negative margins (R0-resection) and an adequate lymph-node-dissection (D2-lymphadenectomy). Unfortunately, most cases of gastric cancer are only diagnosed at an advanced stage due to frequent recurrences after primary resection in curative intent. In order to improve prognosis after curative resection, in the recent past, patients with locally advanced tumors were subjected to a pre-, peri-, or postoperative treatment. Interestingly, postoperative chemotherapy has significantly improved survival after gastric resection in Asia, adjuvant radiochemotherapy is favored in North America and perioperative chemotherapy is considered as a treatment of choice in Europe indicating region specific approach towards the treatment. Recently there has also been growing evidence of positive outcomes of neoadjuvant radiochemotherapy on patient survival. In the present article, we discuss the concepts of neoadjuvant treatment approach and provide recommendations to surgeons based on current evidence.
Monika C. Schuhmacher,Sergej von Janda,아크우드사이드 한국마케팅과학회 2014 Journal of Global Fashion Marketing Vol.5 No.1
The study here applies fuzzy set qualitative comparative analysis (QCA) to offerconfigurations that are sufficient to identify “Clotheshorses”, “Clothesaholics”,“Clothesgourmands” and “Clothesnegators”. In contrast to prior literature investigatingonly clothes shopping frequency, we find these four clothes shopper types are different with regard to the perceived “importance of dressing well”. The findings demonstrate the existence of these four stalwart segments.
Tracing flavonoid degradation in grapes by MS filtering with stable isotopes
Chassy, Alexander W.,Bueschl, Christoph,Lee, Hyeyoung,Lerno, Larry,Oberholster, Anita,Barile, Daniela,Schuhmacher, Rainer,Waterhouse, Andrew L. Elsevier 2015 Food chemistry Vol.166 No.-
<P><B>Abstract</B></P> <P>Anthocyanin degradation has been proposed as one of the primary causes for reduced colour and quality in red wine grapes grown in a warm climate. To study anthocyanin degradation we infused berries with <SMALL>L</SMALL>-phenyl-<SUP>13</SUP>C<SUB>6</SUB>-alanine and then tracked the fate of the anthocyanins comparing normal (25°C) and warm (45°C) temperature conditions. An untargeted metabolomics approach was aided by filtering the MS data using software algorithms to extract all M and M+6 isotopic peak pairs, allowing the analysis to focus solely on the metabolites of phenylalanine. A paired-comparison <I>t</I>-test was performed over the 8 biological replicates revealing 13 metabolites that were statistically different between 25°C and 45°C treatments. Most of these features had lower abundances in 45°C samples, confirming that 45°C treatment caused anthocyanin degradation. In addition, resveratrol was significantly reduced following heat treatment. However, 5 metabolites increased following the 45°C treatment. These unidentified metabolites are therefore suspects for anthocyanin degradation products.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We combined <SUP>13</SUP>C isotopic labelling and LC-HRMS based metabolomics. </LI> <LI> Phenylalanine-derived compounds in grapes were filtered using untargeted profiling. </LI> <LI> Thermal degradation products of known and unknown berry metabolites were detected. </LI> <LI> Warm temperature (45°C) treatment decreased anthocyanins as expected. </LI> <LI> Warm temperature produced 5 metabolites that may be anthocyanin degradation products. </LI> </UL> </P>
Kim, Young-Woo,Joo, Jungnam,Yoon, Hong Man,Eom, Bang Wool,Ryu, Keun Won,Choi, Il Ju,Kook, Myeong Cherl,Schuhmacher, Christoph,Siewert, Joerg Ruediger,Reim, Daniel Williams & Wilkins Co 2016 Medicine Vol.95 No.28
<P><B>Abstract</B></P><P>Several retrospective analyses on patients who underwent gastric cancer (GC) surgery revealed different survival outcomes between Eastern (Korean, Japanese) and Western (USA, Europe) countries due to potential ethnical and biological differences. This study investigates treatment outcomes between specialized institution for GC in Korea and Germany.</P><P>The prospectively documented databases of the Gastric Cancer Center of the National Cancer Center, Korea (NCCK) and the Department of Surgery of the Technische Universitaet Muenchen (TUM), Germany were screened for patients who underwent primary surgical resection for GC between 2002 and 2008. Baseline characteristics were compared using <I>χ</I><SUP>2</SUP> testing, and 2 cohorts were matched using a propensity score matching (PSM) method. Patients’ survival was estimated using Kaplan–Meier method, and multivariable Cox proportional hazard model was used for comparison.</P><P>Three thousand seven hundred ninety-five patients were included in the final analysis, 3542 from Korea and 253 from Germany. Baseline characteristics revealed statistically significant differences for age, tumor location, pT stage, grading, lymphatic vessel infiltration (LVI), comorbidities, number of dissected lymph nodes (LN), postoperative complications, lymph-node ratio stage, and application of adjuvant chemotherapy. After PSM, 171 patients in TUM were matched to NCCK patients, and baseline characteristics for both cohorts were well balanced. Patients in Korea had significantly longer survival than those in Germany both before and after PSM. When the analysis was performed for each UICC stage separately, same trend was found over all UICC stages before PSM. However, significant difference in survival was observed only for UICC I after PSM.</P><P>This analysis demonstrates different survival outcomes after surgical treatment of GC on different continents in specialized centers after balancing of baseline characteristics by PSM.</P>
G. Mueller,W. An,Th. Berghofer,M. DelGiacco,Ch. Eing,R. Fetzer,B. Flickinger,W. Frey,H. Giese,M. Gottel,Ch. Gusbeth,A. Heinzel,P. Hoppe,A. Jianu,F. Lang,K. Leber,M. Sack,G. Schuhmacher,J. Singer,R. St 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.61
In this paper, we review the progress that has been achieved at Karlsruhe Institute of Technology (KIT) for several industrial scale projects and in basic investigations based on intense particle beams and pulsed power technologies.