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RISS 인기검색어
- 검색키워드
- 저자 : Sayantan Ray (검색결과 2 건)
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Formulation, development and optimization of mouth dissolving tablets of Rizatriptan benzoate
Bijaya Ghosh,Sayantan Ray,Moumita Das 한국약제학회 2015 Journal of Pharmaceutical Investigation Vol.45 No.6
Rizatriptan benzoate, a drug used to treat migraine needs quick action, for which mouth dissolving tablets (MDTs) of the drug may be suitable. However, the bitter taste of drug pose a major challenge to the development of MDTs of the drug. In the present study, MDTs were developed after masking the bitter taste of the drug through solid dispersion. The solid dispersions of Rizatriptan benzoate were prepared with PEG 6000 and mannitol in various ratios and the taste of the formulations was evaluated by willing volunteers and the most acceptable formulation was chosen for development of the MDTs. The MDTs were developed and optimized by using the sequential simplex optimization technique. Disintegration time, hardness and friability of the tablets were considered as the parameters for the optimization of formulations. The optimized formulation showed a disintegration time of 15 s, hardness of 5.2 kg/cm² and friability of 0.5 %. The drug release of 99 % was achieved within 15 min in simulated saliva fluid. Therefore, the MDTs developed in this study could meet the dual need of effectively masking the bitter taste of the drug as well as deliver it quickly, for speedy onset of action and better therapeutic efficacy.
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Arka Dey,Mrinmay Das,Joydeep Datta,Rajkumar Jana,Joydeep Dhar,Sayantan Sil,Debasish Biswas,Chandan Banerjee,Partha Pratim Ray 대한금속·재료학회 2016 ELECTRONIC MATERIALS LETTERS Vol.12 No.4
Here we have presented the results of large area (30 × 30 cm2) siliconhydrogenalloy material and solar cell by argon dilution method. As analternative to hydrogen dilution, argon dilution method has been appliedto develop single junction solar cell with appreciable stability. Optimization of deposition conditions revealed that 95% argon dilutiongives a nanostructured material with improved transport property andless light induced degradation. The minority carrier diffusion length (Ld)and mobility-lifetime (μτ) product of the material with 95% argondilution degrades least after light soaking. Also the density of states(DOS) below conduction level reveals that this material is lessdefective. Solar cell with this argon diluted material has been fabricatedwith all the layers deposited by argon dilution method. Finally we havecompared the argon diluted solar cell results with the optimizedhydrogen diluted solar cell. Light soaking study proves that it is possibleto develop stable solar cell on large area by argon dilution method andthat the degradation of argon diluted solar cell is less than that ofhydrogen diluted one.
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