http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Sarvesh Kumar Paliwal (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Paul Sangeeta,Sharma Swapnil,Paliwal Sarvesh Kumar,Kasture S. B. 경희대학교 융합한의과학연구소 2020 Oriental Pharmacy and Experimental Medicine Vol.20 No.2
Grewia asiatica L. (family-Malvaceae) commonly known as phalsa has been used traditionally as Rasayana which has a role in ameliorating cognitive decline and has a stimulant effect. The present study was conducted with an aim to investigate whether G. asiatica berries ameliorates cognitive deficits induced by scopolamine. In this experimental work, cognition enhancement activity of G. asiatica extracts (200 mg/kg) was assessed against scopolamine-induced amnesia using elevated plus maze model. To assess the protective potential of G. asiatica on scopolamine-induced damages effect on acetylcholinesterase (AChE), lipid peroxidase and superoxide dismutase, contents were estimated in rat brain homogenate spectrophotometrically and histopathological studies were done. Effect of methanol extract of G. asiatica (200 and 400 mg/kg) was assessed on dopamine and serotonin-mediated behavior using haloperidol-induced catalepsy and lithium-induced head twitches model respectively. Results showed that methanol extract of G. asiatica caused restoration of memory caused due to scopolamine-induced amnesia as measured on behavioral paradigms by elevating neurotransmitter acetylcholine, amelioration of oxidative stress markers, restoration of damaged neuronal cells cytoarchitecture and modulation of monoamines mediated behavior eliciting role of phalsa as promising nootropic candidate.
-
Sangeeta Paul,Swapnil Sharma,Sarvesh Kumar Paliwal,Sanjay Kasture 경희대학교 융합한의과학연구소 2017 Oriental Pharmacy and Experimental Medicine Vol.17 No.4
Treatment of cognitive disorders is a challenging task in neurology since long time. Crataegus oxyacantha, also known as hawthorn belongs to family Rosaceae grown in colder areas and is one of the most widely used herb for the treatment of heart disorders. Traditionally Crataegus oxyacantha has also been used to treat Alzheimer disease, nervousness, stress, pain, and sleep disorders. In this study nootropic activity of petroleum ether, chloroform and methanol extract of Crataegus oxyacantha leaves was assessed using elevated plus maze model. Scopolamine (1 mg/kg) was used as amnesia inducing agent and piracetam (120 mg/kg) as standard nootropic drug. On the last day of the experiment, biochemical parameters like acetylcholinesterase, lipid peroxidase and superoxide dismutase were measured in brain homogenate. Effect of Crataegus oxyacantha on monoamines mediated behaviour was assessed through lithium induced head twitches and haloperidol induced catalepsy model in rats. Among all three extracts, methanol extract of Crataegus oxyacantha caused highest reduction in transfer latency time significantly as measured on 7th and 14th day and on 8th and 15th day on elevated maze and also decreased acetylcholinesterase and lipid peroxidase level and increased super oxide dismutase content as compared to scopolamine group. Methanol extract of Crataegus oxyacantha (200 mg/kg and 400 mg/kg) decreased number of head twitches and duration of catalepsy in rats significantly compared to vehicle treated group. So our study showed promising effect of Crataegus oxyacantha in enhancing learning and memory due to the presence of certain phytoconstituents.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
