A Population-Based Study of Factors Associated With Nocturia in Reproductive-Aged Turkish Women

Haşmet Sarici,Onur Telli,Berat Cem Özgür,Ömer Gökhan Doluoğlu,Muzaffer Eroğlu,Selen Bozkurt 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.6

Purpose: This study aimed to investigate the prevalence of nocturia according to theInternational Continence Society (ICS) definition in Turkish women and to determinethe associated risk factors and the correlation of other voiding symptoms with nocturia. Materials and Methods: A prospective epidemiological study was carried out by useof self-reported questionnaires in 4,250 reproductive-aged women from January 2013to May 2013. The International Consultation on Incontinence Questionnaire-ShortForm and a questionnaire developed by the researchers according to the ICS were administeredto define nocturia and other lower urinary tract symptoms. Other physical,reproductive, and health characteristics were also recorded concurrently. Results: Overall, 1,636 women were included in the final analyses. The women had anaverage age of 34.4±5.26 years. The overall prevalence of nocturia was 34.7% (567 of1,636 women). Women with nocturia were older (p<0.001), had a higher body massindex (p=0.026), and had more children (p<0.001). Nocturia occurred more frequentlyin women with a history of nocturnal enuresis (p<0.001). Three or more pregnancies,3 or more deliveries, and age >40 years were significant risk factors for nocturia. Wealso found that other lower urinary tract symptoms correlated significantly (p<0.001)with nocturia. Conclusions: Although the prevalence of nocturia is higher with increasing age, youngeradults are also affected. Nocturia may cause sleep disorders, mood disturbances, reducedquality of life, and distractibility. Thus, even if one void nightly causes a patientto experience bother, nocturia should be queried about and should be treated if necessaryaccording to the cause of the disease.

Bearing capacity of footing supported by geogrid encased stone columns on soft soil

Demir, Ahmet,Sarici, Talha Techno-Press 2017 Geomechanics & engineering Vol.12 No.3

The stone columns are increasingly being used as a soil improvement method for supporting a wide variety of structures (such as road embankment, buildings, storage tanks etc.) especially built on soft soil. Soil improvement by the stone column method overcomes the settlement problem and low stability. Nevertheless, stone column in very soft soils may not be functional due to insufficient lateral confinement. The required lateral confinement can be overcome by encasing the stone column with a suitable geosynthetic. Encasement of stone columns with geogrid is one of the ideal forms of improving the performance of stone columns. This paper presents the results of a series of experimental tests and numerical analysis to investigate the behavior of stone columns with and without geogrid encasement in soft clay deposits. A total of six small scale laboratory tests were carried out using circular footing with diameters of 0.05 m and 0.1 m. In addition, a well-known available software program called PLAXIS was used to numerical analysis, which was validated by the experimental tests. After good validation, detailed of parametric studies were performed. Different parameters such as bearing capacity of stone columns with and without geogrid encasement, stiffness of geogrid encasement, depth of encasement from ground level, diameter of stone columns, internal friction angle of crushed stone and lateral bulging of stone columns were analyzed. As a result of this study, stone column method can be used in the improvement of soft ground and clear development in the bearing capacity of the stone column occurs due to geogrid encasement. Moreover, the bearing capacity is effected from the diameter of the stone column, the angle of internal friction, rigidity of the encasement, and depth of encasement. Lateral bulging is minimized by geogrid encasement and effected from geogrid rigidity, depth of encasement and diameter of the stone column.

Use of uncertain numbers for appraising tensile strength of concrete

Bulent Tutmez,A. Kemal Cengiz,Didem Eren Sarici 국제구조공학회 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.46 No.4

Splitting tensile strength (STS) is a respectable mechanical property reflecting ability of the concrete. The STS of concrete is mainly related to compressive strength (CS), water/binder (W/B) ratio and concrete age. In this study, the assessment of STS is made by a novel uncertainty-oriented method which uses least square optimization and then predicts STS of concrete by uncertain (fuzzy) numbers. The approximation method addresses a novel integration of fuzzy set theory and multivariate statistics. The numerical examples showed that the method is applicable with relatively limited data. In addition, the prediction of uncertainty at various levels of possibility can be described. In conclusion, the uncertaintyoriented interval analysis can be suggested an effective tool for appraising the uncertainties in concrete technology.

Does the Time From Biopsy to Radical Prostatectomy Affect Gleason Score Upgrading in Patients With Clinical T1c Prostate Cancer?

Muzaffer Eroglu,Omer Gokhan Doluoglu,Hasmet Sarici,Onur Telli,Berat Cem Ozgur,Selen Bozkurt 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.6

Purpose: It is debated whether treatment delay worsens oncologic results in localizedprostate cancer (PCa). Few studies have focused on the role of a delay between the timeof biopsy and the time of surgery. Thus, we aimed to investigate the effect of the timeperiod between biopsy and surgery on Gleason score upgrading (GSU). Materials and Methods: A total of 290 patients who underwent radical retropubic prostatectomyin Ankara Training and Research Hospital were included in the study. Thebiopsy Gleason score, age, total prostate-specific antigen (PSA) value, prostate volumes,and PSA density (PSAD) were analyzed in all patients. The patients were dividedinto two groups: patients with GSU (group 1) and patients without GSU (group 2). Variables having a p-value of ≤0.05 in the univariate analysis were selected and thenevaluated by use of multivariate logistic regression models. Results were consideredsignificant at p<0.05. Results: GSU occurred in 121 of 290 patients (41.7%). The mean age of the patientswas 66.0±7.2 years in group 1 and 65.05±5.60 years in group 2 (p=0.18). The mean PSAvalues of groups 1 and 2 were 8.6±4.1 and 8.8±4.3 ng/dL, respectively. The mean prostatevolumes of groups 1 and 2 were 43.8±14.1 and 59.5±29.8 mL, respectively. ThePSAD of group 1 was significantly higher than that of group 2 (0.20 vs. 0.17, p=0.003). The mean time to surgery was shorter in group 2 (group 1, 52.2±22.6 days; group 2,45.3±15.5 days; p=0.004). According to the logistic regression, time from biopsy to surgeryis important in the prediction of GSU. Conclusions: We suggest that the time period between biopsy and surgery is a significantfactor that affects GSU in patients with clinically localized PCa.

Use of uncertain numbers for appraising tensile strength of concrete

Tutmez, Bulent,Cengiz, A. Kemal,Sarici, Didem Eren Techno-Press 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.46 No.4

Splitting tensile strength (STS) is a respectable mechanical property reflecting ability of the concrete. The STS of concrete is mainly related to compressive strength (CS), water/binder (W/B) ratio and concrete age. In this study, the assessment of STS is made by a novel uncertainty-oriented method which uses least square optimization and then predicts STS of concrete by uncertain (fuzzy) numbers. The approximation method addresses a novel integration of fuzzy set theory and multivariate statistics. The numerical examples showed that the method is applicable with relatively limited data. In addition, the prediction of uncertainty at various levels of possibility can be described. In conclusion, the uncertainty-oriented interval analysis can be suggested an effective tool for appraising the uncertainties in concrete technology.

Comparison of Three Different Induction Regimens for Nasopharyngeal Cancer

Kertmen, Neyran,Aksoy, Sercan,Cengiz, Mustafa,Yazici, Gozde,Keskin, Ozge,Babacan, Taner,Sarici, Furkan,Akin, Serkan,Altundag, Kadri,Gullu, H. Ibrahim Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.1

Background: The standard treatment of local advanced nasopharyngeal cancer is chemoradiotherapy. There is a lack of data concerning induction therapy. In this study we retrospectively examined patients treated with induction therapy and chemoradiotherapy. Materials and Methods: Locally advanced nasopharyngeal cancer patients treated between 1996 and 2013 in our clinic were included in the study. Three different induction regimens were administered to our patients in different time periods. The regimen dosages were: CF regimen, cisplatin $50mg/m^2$ 1-2 days, fluorouracil $500mg/m^2$ 1-5 days; DC, docetaxel $75mg/m^2$ 1 day, cisplatin $75mg/m^2$ 1 day; and DCF, docetaxel $75mg/m^2$ 1 day, cisplatin $75mg/m^2$ 1 day, 5-Fu $750mg/m^2$ 1-5 days. Most of the patients were stage III (36.4%) and stage IV (51.7%). Results: Median follow-up time was 50 months (2-201 months). Three-year progression-free survival (PFS) was 79.3%, and 5-year PFS 72.4% in all patients. Three-year overall survival (OS) was 87.4% and 5-year OS 76% in all patients. In terms of induction therapies, 3-year OS was 96.5% in the DCF group, 86.6% in the DC group and 76.3% in the CF group (p=0.03). Conclusions: There was no significant differences in response rate and PFS between the three regimens. OS in the DCF group was significantly higher than in the other groups. However, this study was retrospective and limited toxicity data were available; the findings therefore need to be interpreted with care.