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      저자 : Hasmet Sarici (검색결과 1 건)
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        Does the Time From Biopsy to Radical Prostatectomy Affect Gleason Score Upgrading in Patients With Clinical T1c Prostate Cancer?

        Muzaffer Eroglu,Omer Gokhan Doluoglu,Hasmet Sarici,Onur Telli,Berat Cem Ozgur,Selen Bozkurt 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.6

        Purpose: It is debated whether treatment delay worsens oncologic results in localizedprostate cancer (PCa). Few studies have focused on the role of a delay between the timeof biopsy and the time of surgery. Thus, we aimed to investigate the effect of the timeperiod between biopsy and surgery on Gleason score upgrading (GSU). Materials and Methods: A total of 290 patients who underwent radical retropubic prostatectomyin Ankara Training and Research Hospital were included in the study. Thebiopsy Gleason score, age, total prostate-specific antigen (PSA) value, prostate volumes,and PSA density (PSAD) were analyzed in all patients. The patients were dividedinto two groups: patients with GSU (group 1) and patients without GSU (group 2). Variables having a p-value of ≤0.05 in the univariate analysis were selected and thenevaluated by use of multivariate logistic regression models. Results were consideredsignificant at p<0.05. Results: GSU occurred in 121 of 290 patients (41.7%). The mean age of the patientswas 66.0±7.2 years in group 1 and 65.05±5.60 years in group 2 (p=0.18). The mean PSAvalues of groups 1 and 2 were 8.6±4.1 and 8.8±4.3 ng/dL, respectively. The mean prostatevolumes of groups 1 and 2 were 43.8±14.1 and 59.5±29.8 mL, respectively. ThePSAD of group 1 was significantly higher than that of group 2 (0.20 vs. 0.17, p=0.003). The mean time to surgery was shorter in group 2 (group 1, 52.2±22.6 days; group 2,45.3±15.5 days; p=0.004). According to the logistic regression, time from biopsy to surgeryis important in the prediction of GSU. Conclusions: We suggest that the time period between biopsy and surgery is a significantfactor that affects GSU in patients with clinically localized PCa.

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