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INSULIN RESPONSIVENESS TO GLUCOSE AND TISSUE RESPONSIVENESS TO INSULIN IN SOWS, SHEEP AND PIGS
Sano, H.,Terashima, Y. Asian Australasian Association of Animal Productio 1991 Animal Bioscience Vol.4 No.1
Insulin responsiveness to glucose and tissue responsiveness to insulin, using the hyperglycemic clamp and the hyperinsulinemic euglycemic clamp techniques, were compared among cows, sheep and pigs. The plasma insulin concentrations during the hyperglaycemic clamp period were highest (p < 0.05) in cows, followed by sheep and pigs. The glucose infusion rate in the hyperinsulinemic euglycemic clamp technique was greater (p < 0.01) in pigs than in cows and sheep. These results suggest responsiveness to insulin is higher in pigs than in cows and sheep.
Sano, Tetsuro,Lin, Huai,Chen, Xiashan,Langford, Lauren A.,Bondy, Dimpy Koul Melissa L.,Hess, Kenneth R.,Myers, Jeffery N.,Hong, Yong-Kil,Yung, W.K. Alfred,Steck, Peter A. 가톨릭대학교 2000 Bulletin of The Catholic Research Institutes of Me Vol.28 No.-
MMAC/PTEN, a tumor suppressor gene located on chromosome 10q, has recently been shown to act as a phosphatidylinositol 3,4,5-triphosphate phosphatase and to modulate cell growth and apoptosis. Somatic mutations of MMAC/PTEN have been reported in a number of human cancers, especially in glioblastoma multiforme (GBM), although the number of identified mutations (10-35%) is significantly lower than the frequency of LOH affecting the MMAC/PTEN locus in the specimens (75-95%). To further investigate the possible alterations that may affect MMAC/PTEN, we examined the expression of the gene by reverse transcription-PCR in a series of gliomas. A significant difference (P<0.001) was observed between the expression of MMAC/PTEN in GBMs versus lower grades of gliomas, thus mimicking the difference in allelic deletion associated with the locus in these tumors. Furthermore, Kaplan-Meier survival plots, adjusted for age and tumor grade, showed a significantly better prognosis for patients whose tumors expressed high level of MMAC/PTEN. Additionally, immunostaining of GBMs revealed little or no MMAC/PTEN expression in about two-thirds of the tumors, whereas the other approximately one-third of tumors had significantly higher levels of expression. However, in about two-thirds of the gigh-expressing specimens, a heterogeneous pattern of expression was observed, indicating that certain cells within the tumor failed to express MMAC/PTEN. The combination of these results suggest that, in addition to molecular alterations affecting the gene, altered expression of MMAC/PTEN may play a significant role in the progression of GBM and patient outcome. (Cancer Research 59:1820-1824, 1999)
Sano, Naoki,Tomita, Wataru,Hara, Shu,Min, Cheong-Min,Lee, Jae-Suk,Oyaizu, Kenichi,Nishide, Hiroyuki American Chemical Society 2013 ACS APPLIED MATERIALS & INTERFACES Vol.5 No.4
<P>A highly cross-linked polyviologen hydrogel, poly(tripyridiniomesitylene) (PTPM), has been designed as an anode-active material. It displays a reversible two-electron redox capability at −0.4 and −0.8 V vs Ag/AgCl in an aqueous electrolyte. The PTPM layer coated on a current collector by electropolymerization via a 4-cyanopyridinium electro-coupling reaction demonstrates a rapid charging-discharging reaction with a redox capacity comparable to that obtainable using the formula weight-based theoretical density, because of the combination of the redox-active viologen moieties built into the hydrogel. A test cell that has been fabricated using the developed PTPM anode, a poly(2,2,6,6-tetramethylpiperidinyloxy-4-yl acrylamide) (PTAm)-based cathode, and an aqueous electrolyte exhibits a discharging voltage of 1.1 and 1.5 V, and has proven its ability to be recharged more than 2000 times.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2013/aamick.2013.5.issue-4/am302647w/production/images/medium/am-2012-02647w_0012.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am302647w'>ACS Electronic Supporting Info</A></P>
KOREAN SECURITY: IN THE NATIONAL INTERESTS?
Sano, John R. The Institute for Far Eastern Studies Kyungnam Uni 1978 ASIAN PERSPECTIVE Vol.2 No.2
The relationship that exists between national interests and national security is a very complex and often ambiguous one. As individual countries formulate foreign policy in terms of their own national interests, specifically the attainment and defense of particular goals defined in terms of those interests, this complexity increases significantly. A few national interests, generally those involving geographic factors, may be closely associated with physical security and command a lasting and general domestic consensus that their defense is vital for security.