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        Active tendon control of suspension bridges

        André Preumont,Matteo Voltan,Andrea Sangiovanni,Bilal Mokrani,David Alaluf 국제구조공학회 2016 Smart Structures and Systems, An International Jou Vol.18 No.1

        The paper first reviews the theory of active tendon control with decentralized Integral Force Feedback (IFF) and collocated displacement actuator and force sensor; a formal proof of the formula giving the maximum achievable damping is provided for the first time. Next, the potential of the control strategy for the control of suspension bridges with active stay cables is evaluated on a numerical model of an existing footbridge; several configurations are investigated where the active cables connect the pylon to the deck or the deck to the catenary. The analysis confirms that it is possible to provide a set of targeted modes with a considerable amount of damping, reaching s=15% . Finally, the control strategy is demonstrated experimentally on a laboratory mock-up equipped with four control stay cables equipped with piezoelectric actuators. The experimental results confirm the excellent performance and robustness of the control system and the very good agreement with the predictions.

      • Virtual Symmetry Axes for the Layout of Analog IC's

        Malavasi, Enrico,Charbon, Edoardo,Jusuf, Gani,Totaro, Roberto,Vincentelli, Alberto Sangiovanni 대한전자공학회 1991 ICVC : International Conference on VLSI and CAD Vol.2 No.1

        A new approach to the layout of integrated circuits with multiple symmetry axes is presented in this paper. When more than one symmetry is present, the usual approach to placement grad compaction makes extensive ruse of hierarchy, which requires firmed positions for symmetry ayes. As a result, wiring and area optimizations rare poor. The position of a virtual symmetry axis is variable, and dynamically defined by the center of a group of symmetric modules and wires called cluster. Virtual symmetry axes have been implemented in a placement tool using the Simulated Annealing algorithm and in a compaction tool based on the constraint-graph longest-path algorithm. Results are shown proving the suitability of this approach.

      • The application of markers (HSP70 GPC3 and GS) in liver biopsies is useful for detection of hepatocellular carcinoma

        Di Tommaso, Luca,Destro, Annarita,Seok, Jae Yeon,Balladore, Emanuela,Terracciano, Luigi,Sangiovanni, Angelo,Iavarone, Massimo,Colombo, Massimo,Jang, Ja June,Yu, Eunsil,Jin, So Young,Morenghi, Emanuela Elsevier 2009 Journal of hepatology Vol.50 No.4

        <P><B>Background/Aims</B></P><P>Liver biopsy for hepatocellular carcinoma (HCC) detection is largely restricted to small hepatocellular lesions, which are often morphologically challenging, requiring careful distinction between dysplastic nodules (high-grade) and well-differentiated HCC.</P><P><B>Methods</B></P><P>We investigated the diagnostic accuracy of a panel of markers (HSP70 GPC3 and GS), previously tested in resection specimens, in a series of liver biopsies of large regenerative nodules (<I>n</I>=13), low-grade dysplastic nodules (<I>n</I>=21), high-grade dysplastic nodules (<I>n</I>=50), very well-differentiated (VWD) (<I>n</I>=17), well-differentiated (WD-G1) (<I>n</I>=40) and G2-3 (<I>n</I>=35) HCC.</P><P><B>Results</B></P><P>Almost all cases of large regenerative and low-grade dysplastic nodules did not stain while high-grade dysplastic nodules showed 1 marker (22%) but never 2 or 3. For HCC detection the overall accuracy of marker combination was 60.8% (3 markers) and 78.4% (2 markers) with 100% specificity. When restricted to VWD+WD-G1 HCC the accuracy was 57% (3 markers) and 72.9% (2 markers) with 100% specificity.</P><P><B>Conclusions</B></P><P>This panel proved useful to detect well-differentiated HCC in biopsy. Two immunoreactive markers (out of 3) are recommended as the most valuable diagnostic combination for HCC detection. The diagnostic accuracy of the panel could be improved using additional markers, as suggested by studies of expression profiling in other human models.</P>

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