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Transcriptome analysis of a tropical medicinal plant, Pistacia weinmannifolia
Mi Kyung Choi(Mi Kyung Choi),Bimpe Suliyat Azeez(Bimpe Suliyat Azeez ),Sang Woo Lee(Sang Woo Lee),Wan Yi Li(Wan Yi Li),Sangho Choi(Sangho Choi),Ik-Young Choi(Ik-Young Choi),Ki-Young Choi(Ki-Young (사)한국식물생명공학회 2024 JOURNAL OF PLANT BIOTECHNOLOGY Vol.51 No.1
Regioselective Synthesis of 1,3‐ and 1,2‐Tocopheryl Glyceride Ethers of Carboxylic Acids
Choi, Bo Seul,Choi, Jeongae,Bak, Seonyoung,Koo, Sangho WILEY‐VCH Verlag 2015 European journal of organic chemistry Vol.2015 No.3
<P><B>Abstract</B></P><P>A regioselective synthetic method with which to access 1,3‐tocopheryl glyceride ethers <B>2</B> of diverse carboxylic acids was developed through Bu<SUB>4</SUB>NBr‐catalyzed ring‐opening of tocopheryl glycidyl ether <B>1</B>. Steglich esterification of the 1,3‐tocopheryl acetyl‐glyceride ether <B>2a</B> with various carboxylic acids, followed by selective deprotection of 3‐acetate by LiEt<SUB>3</SUB>BH reduction at –78 °C constitutes a regioselective synthetic method of 1,2‐tocopheryl glyceride ethers <B>4</B>. An example of the differing self‐assembled behavior of phosphorylcholine derivatives <B>6c</B> and <B>7c</B> of 1,3‐ and 1,2‐tocopheryl stearoyl‐glyceride ethers in aqueous solution is also described.</P>
Fuzzy Learning Method Using Genetic Algorithms
Choi, Sangho,Cho, Kyung-Dal,Park, Sa-Joon,Lee, Malrey,Kim, Kitae Korea Multimedia Society 2004 멀티미디어학회논문지 Vol.7 No.6
This paper proposes a GA and GDM-based method for removing unnecessary rules and generating relevant rules from the fuzzy rules corresponding to several fuzzy partitions. The aim of proposed method is to find a minimum set of fuzzy rules that can correctly classify all the training patterns. When the fine fuzzy partition is used with conventional methods, the number of fuzzy rules has been enormous and the performance of fuzzy inference system became low. This paper presents the application of GA as a means of finding optimal solutions over fuzzy partitions. In each rule, the antecedent part is made up the membership functions of a fuzzy set, and the consequent part is made up of a real number. The membership functions and the number of fuzzy inference rules are tuned by means of the GA, while the real numbers in the consequent parts of the rules are tuned by means of the gradient descent method. It is shown that the proposed method has improved than the performance of conventional method in formulating and solving a combinatorial optimization problem that has two objectives: to maximize the number of correctly classified patterns and to minimize the number of fuzzy rules.
Choi, Sangho,Jeong, Hang Jin,Hwang, Kyu-Jam,Gill, Byoungchul,Ju, Young Ran,Lee, Yeong Seon,Lee, Jeongmin Allen Press, etc 2017 The American journal of tropical medicine and hygi Vol.97 No.1
<P><B>Abstract.</B></P><P>We investigated the 47-kDa outer membrane protein (OMP), which is a periplasmic serine protease and an antigenic major surface protein of <I>Orientia tsutsugamushi</I>, as a vaccine candidate. We developed a conventional subunit vaccine expressing recombinant 47-kDa OMP (rec47) and a DNA vaccine (p47). In mouse immunization experiments, intranasal immunization with rec47 alone or with rec47 plus heat-labile enterotoxin B subunit from <I>Escherichia coli</I> or plus cholera toxin (CT) as adjuvants induced a higher amount of rec47-specific antibodies than intramuscular immunization with p47 alone or with p47 plus pBOOST2-samIRF7/3 (pB) as adjuvant. Moreover, the combination of rec47 and CT induced a strong cellular immune response to 47-kDa OMP, as demonstrated by a spleen cell proliferation assay, and also induced Th1- and Th2-type cytokine production, as demonstrated by a cytokine enzyme-linked immunosorbent assay. Intranasal immunization with rec47 plus CT was the most effective method for the induction of humoral and cell-mediated immune responses. Furthermore, relatively strong protection against homologous <I>O. tsutsugamushi</I> strain Boryong challenge was observed in mice immunized with rec47 plus CT. Therefore, 47-kDa OMP is an attractive candidate for developing a prophylactic vaccine against scrub typhus by <I>O. tsutsugamushi</I> infection.</P>
( Sangho Choi ),( Hang Jin Jeong ),( Byoungchul Gill ),( Yeong Seon Lee ),( Jeongmin Lee ) 대한인수공통전염병학회 2016 창립총회 및 학술대회 초록집 Vol.2016 No.1
Background: Scrub typhus is an acute, febrile, and potentially fatal mite-borne disease that is caused by infection with Orientia tsutsugamushi. In Korea, the incidence has increased due to environmental changes and increased outdoor activity leading to frequent exposure to chigger mite vectors. Although the infection is treatable with doxycycline and azithromycin, an effective prophylactic vaccine against O. tsutsugamushi would be more favorable for preventing scrub typhus in the endemic areas. Materials and Methods: We combined the immunoreactive regions of 47-kDa outer membrane protein (47-kDa OMP) and 56-kDa type-specific antigen (TSA56) to generate a conventional subunit vaccine expressing recombinant OTBS56-47 (recOTBS56-47) and a DNA vaccine (pOTBS56-47). We evaluated two types of vaccination, intranasal immunization with recOTBS56-47, and Intramuscular immunization with pOTBS56-47 for immunogenicity and efficacy. Results: In mice, intranasal immunization with recOTBS56-47 plus cholera toxin (CT) was the most effective method for the induction of humoral and cell-mediated immune responses; it induced a strong cellular immune response, as demonstrated by a spleen cell proliferation assay, and induced a higher amount of recOTBS56-47-specific antibodies. Intramuscular immunization with pOTBS56-47 alone, or pOTBS56-47 plus adjuvant pmIL-2, induced a low level of humoral immune response. Conclusion: OTBS56-47 is an attractive candidate for developing a prophylactic vaccine against scrub typhus caused by O. tsutsugamushi. This work was supported by an intramural fund (2013-NG52001-00) by research of Korea Centers for Disease Control and Prevention.