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( Sung Jun Chung ),( Tae Yeob Kim ),( Sun Min Kim ),( Min Roh ),( Mi Yeon Yu ),( Jung Hoon Lee ),( Chang Kyo Oh ),( Eun Young Lee ),( Seung Lee ),( Yong Cheol Jeon ),( Kyo Sang Yoo ),( Joo Hyun Sohn ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.2
Background/Aims: The incidence of symptomatic hepatitis A reportedly increased among 20- to 40-year-old Korean during the late 2000s. Vaccination against hepatitis A was commenced in the late 1990s and was extended to children aged <10 years. In the present study we analyzed the changes in the seroprevalence of IgG anti-hepatitis A virus (HAV) over the past 13 years. Methods: Overall, 4903 subjects who visited our hospital between January 2001 and December 2013 were studied. The seroprevalence of IgG anti-HAV was analyzed according to age and sex. In addition, the seroprevalence of IgG anti-HAV was compared among 12 age groups and among the following time periods: early 2000s (2001-2003), midto- late 2000s (2006-2008), and early 2010s (2011-2013). The chi-square test for trend was used for statistical analysis. Results: The seroprevalence of IgG anti-HAV did not differ significantly between the sexes. Furthermore, compared to the seroprevalence of IgG anti-HAV in the early 2000s and mid-to-late 2000s, that in the early 2010s was markedly increased among individuals aged 1-14 years and decreased among those aged 25-44 years (P<0.01). We also found that the seroprevalence of IgG anti-HAV in individuals aged 25-44 years in the early 2010s was lower than that in the early 2000s and mid-to-late 2000s. Conclusions: The number of symptomatic HAV infection cases in Korea is decreasing, but the seroprevalence of IgG anti-HAV is low in the active population. (Clin Mol Hepatol 2014;20:162-167)
Oh, Yoo Jin,Kim, Hye Young,Lee, Mi Hwa,Suh, Sung Hwan,Choi, Yongmun,Nam, Tae-gyu,Kwon, Woo Young,Lee, Sang Yeob,Yoo, Young Hyun American Society for Pharmacology and Experimental 2018 Molecular pharmacology Vol.94 No.6
<P>Nonalcoholic fatty liver disease (NAFLD) is an increasingly studied condition that can progress to end-stage liver disease. Although NAFLD was first described in 1980, a complete understanding of the mechanism and causes of this disease is still lacking. Six-transmembrane protein of prostate 2 (STAMP2) plays a role in integrating inflammatory and nutritional signals with metabolism. Our previous study suggested that STAMP2 may be a suitable target for treating NAFLD. In the current study, we performed a focused drug-screening and found that cilostazol could be a potential STAMP2 enhancer. Thus, we examined whether cilostazol alleviates NAFLD through STAMP2. The in vivo and in vitro pharmacological efficacies of cilostazol on STAMP2 expression and lipid accumulation were analyzed in NAFLD mice induced by high-fat diet (HFD) and in HepG2 cell lines treated by oleic acid (OA), respectively. Cilostazol increased the expression of STAMP2 through transcriptional regulation in vivo and in vitro. Cilostazol also dampened the STAMP2 downregulation caused by the HFD and by OA in vivo and in vitro, respectively. Cilostazol activated AMP-activated protein kinase (AMPK) in vivo and in vitro, and AMPK functions upstream of STAMP2, and reversed downregulation of STAMP2 expression through AMPK in the NAFLD model. Cilostazol ameliorates hepatic steatosis by enhancing hepatic STAMP2 expression through AMPK. Enhancing STAMP2 expression with cilostazol represents a potential therapeutic avenue for treatment of NAFLD.</P><P>[Figure]</P>
High Efficiency Exciplex Emitters Using Donor–Acceptor Type Acceptor Material
Oh, Chan Seok,Kang, Yu Jin,Jeon, Sang Kyu,Lee, Jun Yeob American Chemical Society 2015 The Journal of Physical Chemistry Part C Vol.119 No.39
<P>A design rule of the acceptor material of exciplexes was studied by synthesizing two acceptor materials with only acceptor moieties and with both a donor and an acceptor simultaneously. Molecular calculation and photophysical measurements of the exciplexes revealed that the donor acceptor type acceptor materials promoted the exciplex formation by charge transfer character and increased the photoluminescence quantum yield of the exciplexes. The combination of a donor material and the donor acceptor type acceptor material achieved a high quantum efficiency of 12.6% in the green exciplex devices.</P>
버전제어에서 컴포넌트의 형상형성 제어를 위한 객체지향 라이브러리
오상엽(Sang-Yeob Oh),최우승(Woo-Seung Choi) 한국컴퓨터정보학회 2008 韓國컴퓨터情報學會論文誌 Vol.13 No.6
버전 제어 시스템은 급속한 환경의 변화나 개발 환경이 복잡한 프로그래밍 환경에서 사용되고 있으며, 정의된 형상 규칙 정보를 정확하게 알지 못하는 경우나 미리 정의되지 않은 정보에 대해서는 형상 형성 정보 제공 문제가 발생한다. 본 논문에서는 사용자가 원하는 컴포넌트를 복합적으로 형상형성 제어 할 수 있는 라이브러리 시스템을 제안하고, 모델링하여 구현하였다. 제안한 형상형성 제어를 위해 사용되는 라이브러리는 확장 facet 분류를 응용하여 하부 표현 구조에 관계없이 라이브러리로부터 컴포넌트를 검색할 수 있도록 하였다. 이것은 본 논문에서 제안한 TreeSearch 클래스와 형상형성 제어 함수를 이용하여 관리된다. 본 논문의 라이브러리는 다른 언어와의 인터페이스를 통해 사용될 수 있으며, 사용자에 의해 facet이 확장되는 장점을 가진다. A version control system is used in a rapidly changed environment or a program which developed in a complicated environment. it is a problem of configuration thread in supporting information that we, in this method, can't know a exactly well-defined configuration rule information and a predefined information. In this paper. Library system is suggested, modelled, and implemented so as to configuration thread control the components required by the user in many ways. As for the library used in the configuration thread control suggested in this paper, the components can be retrieved from the library regardless of the infrastructure, applying the extended facet classification. This retrieval framework is managed using TreeSearch class and the configuration thread control function. The library system of this paper can be used by the interface with other languages, and this system is to have a advantage to extend a facet by user.
감자 재배 화산회토양에서 질소시비 수준, 강우 및 온도 환경 변화에 따른 아산화질소 배출 특성
양상호(Sang-Ho Yang),강호준(Ho-Jun Kang),이신찬(Shin-Chan Lee),오한준(Han-Jun Oh),김건엽(Gun-Yeob Kim) 한국토양비료학회 2012 한국토양비료학회지 Vol.45 No.4
본 연구는 감자 재배 화산회 토양에서 질소시비 수준 및 강우, 온도 환경 변화에 따른 N₂O 배출량을 측정하고 배출에 영향을 미치는 요인 특성을 구명하기 위하여 제주특별자치도농업기술원 시험포장에서 2년간 (2010~2011년) 수행되었다. 감자 재배기간 동안 N₂O 배출량은 질소시비량이 많을수록 많았다. 재배시기별 N₂O 배출량은 강우량 많은 시기인 재배 초기와 중기에 많았으나, 강우가 적고 한발 시기인 재배 말기에는 매우 적거나 거의 없는 경향을 보였다. N₂O 배출 양상은 강우량 및 토양수분함량 변화와 대체로 유사한 경향을 보였다. N₂O 배출량과 상관관계 (r)를 분석한 결과, ‘10년도에는 토양수분과 토양온도는 각각 0.6251<SUP>**</SUP>, 0.6082<SUP>**</SUP>로 고도로 유의성이 인정되었으나, 토양 EC와는 0.1082로 유의성은 인정되지 않았다. ’11년도에는 토양온도와는 0.4879<SUP>**</SUP>로 유의성이 인정되었으나, 토양수분과 토양 EC와는 각각 0.0469, 0.0400으로 유의성은 인정되지 않았다. NH₄-N과는 0.7476<SUP>**</SUP>로 고도로 유의성이 인정되었으나, NO₃-N과 토양 질소 (NO₃-N + NH₄-N)와는 각각 0.0843과 0.1797로 유의성이 인정되지 않았다. 질소시비량에 따른 2년 동안의 N₂O 배출량을 배출계수로 환산한 값은 0.0040 N₂O-N ㎏ N?¹ ㎏?¹로 IPCC 가이드라인의 기본계수인 0.0100 N₂O-N ㎏ N?¹ ㎏?¹ 보다는 약 2.5배 낮은 것으로 분석되었다. This study was conducted to investigate the characteristic factors which have been influenced on nitrous oxide (N₂O) emissions related to the environment change of nitrogen application level, rainfall and temperature during the potato cultivation at black volcanic ash soil from 2010 to 2011. During the potato cultivation, the more amount of nitrogen fertilizer applied, N₂O emissions amounts were released much. N₂O emissions with the cultivation time were released much at the first and middle of cultivation with heavy rainfall, but it was released very low until the end of cultivation and drought season. N₂O emissions mainly were influenced by the rainfall and soil water content. The correlation (r) with N₂O emissions, soil wate, soil temperature in 2010 were very significant at 0.6251<SUP>**</SUP> and 0.6082<SUP>**</SUP> respectively, but soil EC was not significant to 0.10824. In 2011, soil temperature was very significant at 0.4879<SUP>**</SUP>, but soil water and soil EC were not significant at 0.0468 and 0.0400 respectively. Also, NH₄-N was very significant at 0.7476<SUP>**</SUP>, but NO₃-N and soil nitrogen (NO₃-N + NH₄-N) were not significant at 0.0843 and 0.1797, respectively. During the potato cultivation period, the average emissions factor of 2 years released by the nitrogen fertilizer application was presumed to be 0.0040 (N₂O-N ㎏ N?¹ ㎏?¹). This factor was lower about 2.5 times than the IPCC guideline default value (0.0100 N₂O-N ㎏ N?¹ ㎏?¹).
Lee, Sung Won,Rho, Jee Hyun,Lee, Sang Yeob,Chung, Won Tae,Oh, Yoo Jin,Kim, Jung Ha,Yoo, Seung Hee,Kwon, Woo Young,Bae, Ju Yong,Seo, Su Young,Sun, Hokeun,Kim, Hye Young,Yoo, Young Hyun Nature Publishing Group UK 2018 Bone research. Vol.6 No.-
<▼1><P>Free fatty acids (FFAs), which are elevated with metabolic syndrome, are considered the principal offender exerting lipotoxicity. Few previous studies have reported a causal relationship between FFAs and osteoarthritis pathogenesis. However, the molecular mechanism by which FFAs exert lipotoxicity and induce osteoarthritis remains largely unknown. We here observed that oleate at the usual clinical range does not exert lipotoxicity while oleate at high pathological ranges exerted lipotoxicity through apoptosis in articular chondrocytes. By investigating the differential effect of oleate at toxic and nontoxic concentrations, we revealed that lipid droplet (LD) accumulation confers articular chondrocytes, the resistance to lipotoxicity. Using high fat diet-induced osteoarthritis models and articular chondrocytes treated with oleate alone or oleate plus palmitate, we demonstrated that articular chondrocytes gain resistance to lipotoxicity through protein kinase casein kinase 2 (PKCK2)—six-transmembrane protein of prostate 2 (STAMP2)—and fat-specific protein 27 (FSP27)-mediated LD accumulation. We further observed that the exertion of FFAs-induced lipotoxicity was correlated with the increased concentration of cellular FFAs freed from LDs, whether FFAs are saturated or not. In conclusion, PKCK2/STAMP2/FSP27-mediated sequestration of FFAs in LD rescues osteoarthritic chondrocytes. PKCK2/STAMP2/FSP27 should be considered for interventions against metabolic OA.</P></▼1><▼2><P><B>Oil droplets protect cartilage from toxic fatty acids</B></P><P>Cartilage tissue deals with the stress of exposure to free fatty acids by sequestering the toxic molecules into sub-cellular oil droplets. Young Hyun Yoo from Dong-A University College of Medicine in Busan, South Korea, and coworkers exposed rat cartilage cells to increasing levels of a fatty acid called oleate, a by-product of fat metabolism, and observed that the accumulation of oil droplets conferred resistance to oleate-induced toxicity. In these rat cells and in experiments involving mouse models of osteoarthritis fed a high-fat diet, the researchers then identified three of the protective proteins needed for cartilage tissue to properly quarantine fatty acids into oil droplets. Those proteins — and their connected regulatory networks — could now serve as drug targets for treating metabolic syndrome-associated osteoarthritis.</P></▼2>