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Alcohol extract of Geum Chung Cho alleviates alcohol-induced short-term memory impairment in gerbils
Han-Sam Cho,Tae-Woon Kim,Sang-Seo Park,Mal-Soon Shin,Jae-Min Lee,Eun-Sang Ji,Chang-Ju Kim 한국운동재활학회 2015 한국운동재활학회 학술대회 Vol.2015 No.10
Chronic ethanol consumption leads to memory impairment and also induces brain damage. The hippocampus has been particularly regarded as a possible target organ of alcoholic intoxication, since this structure plays a prominent function in memory processes. Cordyceps has been used as a traditional medicine in Asian countries for a long time. Different types of Cordyceps extract were reported to have various pharmacological activities including anti-tumor, anti-inflammatory, anti-viral, and immune modulatory effects. Guem Chung Cho is an artificial cultivated Cordyceps, and was supplied from GCordy (Seoul, Korea). Ethanol extract of Cordycep (50 g) was made by rotary evaporate, and resulting powder 8.29 g was obtained (yield 17%). In the present study, we investigated the effects of ethanol extract of Geum Chung Cho on short-term memory, cell proliferation and apoptosis in the hippocampus of ethanol-treated gerbils. The gerbils were divided into 5 groups (n = 10 in each group): Control group, alcohol-treated group, alcohol-treated and 0.001 mg/kg Geum Chung Cho-applied group, alcohol-treated and 0.01 mg/kg Geum Chung Cho-applied group, and alcohol-treated and 0.1 mg/kg Geum Chung Cho-applied group. Gerbils in the alcohol-treated groups were orally administered ethanol (1 g/kg) once a day for 2 weeks. Gerbils in the Guem Chung Cho-applied groups were orally administered Guem Chung Cho extract at each dosage 1 hour before ethanol consumption. Our results revealed that consumption of alcohol for 2 weeks deteriorated short-term memory, induced apoptosis, and inhibited cell proliferation, and reduced expressions of brain-derived neurotrophic (BDNF) and tyrosine kinase B (TrkB). However, Guem Chung Cho treatment alleviated alcohol-induced short-term memory impairment through enhancing cell proliferation and BDNF expression with inhibiting apoptosis in the hippocampus. Guem Chung Cho showed maximum effects at 0.1 mg/kg. Based on these results, alcohol extract of Guem Chung Cho may provide therapeutic value for the treatment of chronic alcohol-inducted brain injury. This study was supported by GCordy company.
Metal stain on monolithic zirconia restoration: A case report
Min-Sang Cha,Sang-Woon Lee,Yoon-Hyuk Huh2,Lee-Ra Cho2,Chan-Jin Park 대한치과보철학회 2017 The Journal of Advanced Prosthodontics Vol.9 No.2
In restorative treatment using fixed dental prostheses, dentists should select appropriate restoration material among various types of dental materials. The strength, marginal fit, esthetics, wear resistance, biocompatibility, and cost are important factors in the choice of restoration materials. The present case showed a surface stain on a monolithic zirconia restoration that was due to wear between the monolithic zirconia restoration and the base metal alloy restoration. This phenomenon was confirmed by surface roughness measurement and electron probe micro-analysis.
High Efficiency Buck-Converter with Short Circuit Protection
Cho, Han-Hee,Park, Kyeong-Hyeon,Cho, Sang-Woon,Koo, Yong-Seo The Institute of Electronics and Information Engin 2014 IEIE Transactions on Smart Processing & Computing Vol.3 No.6
This paper proposes a DC-DC Buck-Converter with DT-CMOS (Dynamic Threshold-voltage MOSFET) Switch. The proposed circuit was evaluated and compared with a CMOS switch by both the circuit and device simulations. The DT-CMOS switch reduced the output ripple and the conduction loss through a low on-resistance. Overall, the proposed circuit showed excellent performance efficiency compared to the converter with conventional CMOS switch. The proposed circuit has switching frequency of 1.2MHz, 3.3V input voltage, 2.5V output voltage, and maximum current of 100mA. In addition, this paper proposes a SCP (Short Circuit Protection) circuit to ensure reliability.
Development of a Full-Scale Driving Simulator for Human Sensibility Ergonomics Study
( Woon Sung Lee ),( Jun Hee Cho ),( Dong Chan Choi ),( Seung Chul Yoo ),( Jun Su Shin ) 한국감성과학회 2000 춘계학술대회 Vol.2000 No.-
A full-scale driving simulator is being developed as an effective test-bed for reproducing realistic driving situation in a safe and tightly controlled environment and conducting various human sensibility ergonomics studies. The simulator will be equipped with a 6 degree-of-freedom, high frequency motion base and a 4 channel, wide field-of-view visual system. The simulator will be fully interactive, highly realistic, and yet economical, taking advantages of the fast growing PC technology.
Cho, Yong-Woo,Kim, Yoo-Shin,Kim, In-San,Park, Rang-Woon,Oh, Seung-Jun,Moon, Dae-Hyuk,Kim, Sang-Yoon,Kwon, Ick-Chan The Polymer Society of Korea 2008 Macromolecular Research Vol.16 No.1
The enhanced permeability and retention (EPR) effect is used extensively for the passive targeting of many macromolecular drugs for tumors. Indeed, the EPR concept has been a gold standard in polymeric anticancer drug delivery systems. This study investigated the tumoral distribution of self-assembled nanoparticles based on the EPR effect using fluorescein and radio-labeled nanoparticles. Self-assembled nanoparticles were prepared from amphiphilic chitosan derivatives, and their tissue distribution was examined in tumor-bearing mice. The size of the nanoparticles was controlled to be 330 run, which is a size suited for opening between the defective endothelial cells in tumors. The long-circulating polymer nanoparticles were allowed to gradually accumulate in the tumors for 11 days. The amount of nanoparticles accumulated in the tumors was remarkably augmented from 3.4%ID/g tissue at 1 day to 25.9%ID/g tissue at 11 days after i.v. administration. The self-assembled nanoparticles were sustained at a high level throughout the 14 day experimental period, indicating their long systemic retention in the blood circulation. The ${\gamma}$-images provided clear evidence of selective tumor localization of the $^{131}I$-labeled nanoparticles. Confocal microscopy revealed the fluorescein-labeled nanoparticles to be preferentially localized in the perivascular regions, suggesting their extravasation to the tumors through the hyperpermeable angiogenic tumor vasculature. This highly selective tumoral accumulation of nanoparticles was attributed to the leakiness of the blood vessels in the tumors and their long residence time in the blood circulation.
Cho, Sung Woon,Kim, Young Been,Kim, Da Eun,Kim, Kyung Su,Yoon, Young Dae,Kang, Won Jun,Lee, Woobin,Cho, Hyung Koun,Kim, Young Hun Elsevier 2017 Journal of alloys and compounds Vol.714 No.-
<P><B>Abstract</B></P> <P>Individual oxide semiconductors and metals experience unique pH-dependent phase-transition into natively stable phases (metal, metal ions, or oxide phases) in various acidic and basic solutions. Thus, the corrosion behavior of oxide semiconductors and metals can be engineered by controlling pH values. In particular, the specific pH value induced interesting corrosion behavior that oxide semiconductor becomes chemically-stable and metal solely experiences active ionization. First, the pH-dependent corrosion behavior of ternary oxide semiconductors [ZnSnO (ZTO) and InZnO (IZO)] and common metals (Mo and Mo/Cu) was explored based on theoretical Pourbaix diagram and experimental corrosion data. Next, the pH-dependent corrosion behavior based back-channel wet-etch (BCWE) process using pH-controlled wet etchants was designed and applied for chemical damage-, metal residue-, and curing treatment-free solution-processed oxide thin film transistors (TFTs) circuit integration without electrical degradation. Thick-Mo and thin-Mo/thick-Cu could be completely ionized without any metal oxide residues in middle-basic (pH ≥ 10) and weak-acidic (pH = 6) wet-etchants, respectively. Chemically durable ZTO in the broad pH region (6 ≤ pH ≤ 11) indicated sufficient potential as channel candidates for the circuit integration of chemical damage-free oxide TFTs as opposed to IZO (pH = 10). Finally, solution-processed ZTO TFTs could be fabricated with wet-etched Mo and Mo/Cu using the customized wet-etchant condition (pH = 10 and 6) without electrical degradation (current-drop, hump phenomena, or instability) that was inevitably generated in a conventional BCWE.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The ternary zinc tin oxide and indium zinc oxide were synthesized via sol-gel process. </LI> <LI> The pH-dependent corrosion behavior of ternary oxides and common metals was examined. </LI> <LI> Oxide film became stable and metal electrode was solely ionized in specific pH value. </LI> <LI> The pH-dependent corrosion behavior based back-channel wet-etch (BCWE) process was developed. </LI> <LI> The developed BCWE process were applied for solution-processed oxide TFTs integration. </LI> </UL> </P>