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Eom Ji-Eun,Kim Gun-Dong,Kim Young In,Lim Kyung min,Song Ju Hye,Kim Yiseul,Song Hyeon-Ji,Shin Dong-Uk,Lim Eun Yeong,Kim Ha-Jung,Kim Sung Hoon,Lee Deuk Sik,Lee So-Young,Shin Hee Soon 한국미생물·생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.5
Chronic obstructive pulmonary disease (COPD), one of the leading causes of death worldwide, is caused by repeated exposure to harmful matter, such as cigarette smoke. Although Lilium longiflorum Thunb (LLT) has anti-inflammatory effects, there is no report on the fermented LLT bulb extract regulating lung inflammation in COPD. Thus, we investigated the protective effect of LLT bulb extract fermented with Lactobacillus acidophilus 803 in COPD mouse models induced by cigarette smoke extract (CSE) and porcine pancreas elastase (PPE). Oral administration of the fermented product (LS803) suppressed the production of inflammatory mediators and the infiltration of immune cells involving neutrophils and macrophages, resulting in protective effects against lung damage. In addition, LS803 inhibited CSE- and LPS-induced IL-6 and IL-8 production in airway epithelial H292 cells as well as suppressed PMA-induced formation of neutrophil extracellular traps in HL-60 cells. In particular, LS803 significantly repressed the elevated IL-6 and MIP-2 production after CSE and LPS stimulation by suppressing the activity of the nuclear factor kappa-light-chainenhancer of activated B (NFκB) in mouse peritoneal macrophages. Therefore, our results suggest that the fermented product LS803 is effective in preventing and alleviating lung inflammation.
Original Article : Softening of Jumbo Squid Dosidicus gigas via Enzyme Injection
( Sung Hwan Eom ),( Sang Hoon Lee ),( Yong Gi Chun ),( Chan Eun Park ),( Dong June Park ) 한국수산과학회(구 한국수산학회) 2015 Fisheries and Aquatic Sciences Vol.18 No.2
We developed a new softening technology applicable to the main body of the jumbo squid Dosidicus gigas; this will aid in squid consumption by elderly individuals and those who have masticatory and dysphagia problems. Protease solutions were injected into jumbo squid and hardness was measured using a texture analyzer. Seven enzymes were tested. Jumbo squid became progressively softer during bromelain and collupulin treatment; the hardness attained 5.6 × 103 N/m2 at bromelain concentrations of 1.00% (w/v) and 6.7 × 103 N/m2 at collupullin concentrations of 1.00% (w/v). The extents of tissue softening after bromelain and collupulin injection to 0.1%, 0.25%, 0.50%, and 1.00% (all w/v) were evaluated; the squid retained its shape after steaming for 10 min at 100℃ to inactivate the enzymes. Thus, the results of this research indicate that enzyme injection softens the texture of jumbo squid.
( Sung Hwan Eom ),( Jeniel A. Santos ),( Ji Hoon Kim ),( Won Kyo Jung ),( Do Hyung Kim ),( Young Mog Kim ) 한국수산과학회(구 한국수산학회) 2015 Fisheries and Aquatic Sciences Vol.18 No.3
In an effort to discover alternative phytotherapeutic antimicrobial agents to combat Streptococcus parauberis, a fish pathogenic bacterium, we evaluated the antibacterial activity of seaweed extracts in vitro. A methanolic extract of Ecklonia cava exhibited strong antibacterial activity against S. parauberis isolated from olive flounder Paralichthys olivaceus. Furthermore, the n hexane soluble (Hexane) fraction of the E. cava methanolic extract exhibited the greatest antibacterial effect on S. parauberis strains with a minimum inhibitory concentration (MIC) ranging from 256 to 1,024 μg/mL. In addition, the MIC values of oxytetracycline against antibiotic-resistant S. parauberis were markedly reduced up to 64-fold in combination with the Hexane fraction, suggesting that the antibacterial activity of the antibiotic was restored when combined with the Hexane fraction. The interaction between both antibiotics and the Hexane fraction was assessed by the fractional inhibitory concentration (FIC) index. The Hexane fraction and oxytetracycline combination against antibiotic-resistant S. parauberis strains resulted in a median ∑FIC range of 0.502 to 0.516. Thus, the synergistic ranges of median ∑FIC < 1 were observed for all combinations of the Hexane fraction and oxytetracycline against S. parauberis. To the best of our knowledge, this is the first report indicating the efficacy of an E. cava extract against fish pathogenic bacterium S. parauberis.
Eom, Sung-Hwan,Jung, Yeoun-Joong,Lee, Dae-Sung,Yim, Mi-Jin,Kim, Hye Seon,Lee, Sang-Hoon,Myeong, Jeong-In,Lee, Jinhwan,Kim, Hyun-Woo,Kim, Kyoung-Ho PRAGATI PRESS- INDIA 2016 Journal of environmental biology Vol.37 No.1
<P>Traditional medicinal plants contain a wide variety of chemicals that have potent antibacterial activity. To find an alternative agent of overcoming the problems of methicillin-resistant Staphylococcus aureus (MRSA), the antibacterial mechanism of Ponciruss trifoliata against MRSA was investigated. Ethyl acetate (EtOAc)-soluble extract of P. trifoliata methanolic extract was evaluated for antibacterial activity using minimum inhibitory concentration (MIC). An EtOAc sub-fraction 08 (EA08) from silica-gel open column chromatography exhibited strong anti-MRSA activity. Apart from the study to isolate single compound from EA08, a synergistic antibacterial effect between the sub-fraction and beta-lactam antibiotics against MRSA was determined. In order to elucidate the antibacterial restoring mechanism of EA08 on MRSA, mRNA expression of mecA gene and production penicillin-binding protein 2a (PBP2a) encoded by mecA gene were monitored. EA 08 showed the strongest antibacterial activity with MIC value of 256 mu g ml(-1). MIC of oxacillin against MRSA was dramatically reduced from 512 to 16 mu g ml(-1) in combination with 256 mu g ml(-1) of EA08. The fractional inhibitory concentration index of oxacillin was measured at 0.53 in combination with EA08 against MRSA, suggesting that EA08-oxacillin combinations exert synergetic effect against MRSA. The analysis of RT-PCR and Western blotting profiles revealed that EA08 inhibited mRNA expression of mecA gene and production PBP2a, which is a key determinant for beta-lactam antibiotic resistance, in a dose-dependent manner. These results indicated that EA08 eventually led to the reduction or inhibition of PBP2a production through translational inhibition in MRSA.</P>
Eom, Seung Hun,Kim, Hee Su,Do, Hee Jin,Lee, Un-Hak,Wibowo, Febrian Tri Adhi,Hwang, Do-Hoon,Yoon, Sung Cheol,Jung, In Hwan Elsevier 2018 Dyes and pigments Vol.156 No.-
<P><B>Abstract</B></P> <P>Perylene diimide (PDI) based high bandgap acceptors, DTBTP, DTF2BTP, and DTF2TZP, are synthesized for use in fullerene-free organic solar cells. The two PDI rings are connected to the end of the n-type core, forming a PDI-n-type core-PDI structure. Several n-type core materials, 4,7-dithieno-2,1,3-benzothiadiazole (DTBT), 5,6-difluoro-4,7-dithieno-2,1,3-benzothiadiazole (DTF2BT), and 4,6-difluoro-2H-benzo[d][1,2,3]triazole (DTF2TZ), are incorporated in the PDI acceptors and the n-type core effect on photovoltaic properties is studies. The introduction of alkyl side chains onto the core structure weakened the intermolecular interaction, whereas fluorination of the core structure improved the backbone planarity and intermolecular ordering. DTF2BTP having a planar core structure without bulky alkyl chains yielded the best power conversion efficiency, 4.41%, when mixed with PTB7-Th donor. The n-type core structure was beneficial in terms of increasing the electron accepting properties and the absorption in the high bandgap region of non-fullerene acceptors.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We synthesized novel n-type core incorporated perylene diimide (PDI) acceptors. </LI> <LI> Panchromatic absorption was achieved via high bandgap PDI acceptors and a low bandgap donor, PTB7-Th. </LI> <LI> The n-type core effect of non-fullerene acceptors was systemically analyzed by morphological studies. </LI> <LI> The fluorinated planar core structure provided the best PCE of 4.41%. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Colorimetric Sensors for Toxic and Hazardous Gas Detection: A Review
Sung Hwan Cho,Jun Min Suh,Tae Hoon Eom,Taehoon Kim,Ho Won Jang 대한금속·재료학회 2021 ELECTRONIC MATERIALS LETTERS Vol.17 No.1
Since the industries are vastly rising, the threat of toxic and hazardous substance to human beings and demands of the accuratesensor is increasing. Colorimetric sensors that detect substances by measuring the absorbance or fluorescence spectra shiftare one of the most emerging strategies these days. However, conventional colorimetric gas sensors are limited to specificapplication due to the limitation of detecting only liquid phase substances. For practical applications of the colorimetric sensors,it is necessary to detect low concentrations of toxic and hazardous substances in gaseous media. Besides, operation withlow power consumption and excellent selectivity and sensitivity should be considered for Internet of Things (IoT) application. In this paper, various efforts on the investigation of several materials, including dyes, polymers, metal–organic complexes,and metal oxides as active sensor elements of the colorimetric gas sensors for IoT application are summarized. This paperalso reviews various kinds of colorimetric gas sensor that exhibit great sensing properties to toxic and hazardous gases andintroduce a brief overview of the challenges of colorimetric gas sensors as a candidate for future IoT gas sensor technology.
Texture Softening of Beef and Chicken by Enzyme Injection Process
Sung Hwan Eom,Sang Hoon Lee,Yong Gi Chun,Bum Keun Kim,Dong June Park 한국축산식품학회 2015 한국축산식품학회지 Vol.35 No.4
This research focuses on a new softening technology for use with chicken breast and eye of round beef in order to assist elderly individuals who have difficulty with eating due to changes in their ability to chew (masticatory function) or swallow. We investigated the hardness of chicken breast and eye of round beef through use of a texture analyzer after injection of a commercial enzyme. Among 7 commercial enzymes, bromelain and collupulin exhibited a marked softening effect on the tested chicken breast and eye of round beef given a 1.00% enzyme concentration. The hardness of bromelain-treated chicken breast reached 1.4×104 N/m2, of collupulin-treated chicken breast reached 3.0×104 N/m2, and of bromelain-treated eye of round beef reached 3.2×104 N/m2, respectively, while their original shapes did not change. To find the level of tissue degradation with specific enzyme concentrations, enzyme injections at 0.1%, 0.25%, 0.50%, and 1.00% concentration of bromelain and papain were also evaluated. The results of this research could be useful for softening chicken breast and eye of round beef and will contribute to the development of foods that can be more easily eaten as part of a balanced diet for elderly adults.