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Jeon Sungmi,Kim Iljin,Na Yi Rang,Yong Hong Ki,Chang Hak,Kim Seung Hwan,Jeong Yu Jin,Chung Jee Hyeok,Kim Sang Wha 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.6
BACKGROUND: Adipose-derived stem cells (ADSCs) exert immunomodulatory effects in the treatment of transplant rejection. This study aimed to evaluate the effects of ADSCs on the skin graft survival in a human-to-rat xenograft transplantation model and to compare single and multiple injections of ADSCs. METHODS: Full-thickness human skin xenografts were transplanted into the backs of Sprague–Dawley rats. The rats were injected subcutaneously on postoperative days 0, 3, and 5. The injections were as follows: triple injections of phosphate-buffered saline (PBS group), a single injection of ADSCs and double injections of PBS (ADSC 9 1 group), and triple injections of ADSCs (ADSC 9 3 group). The immunomodulatory effects of ADSCs on human skin xenografts were assessed. RESULTS: Triple injections of ADSCs considerably delayed cell-mediated xenograft rejection compared with the PBS and ADSC 9 1 groups. The vascularization and collagen type 1–3 ratios in the ADSC 9 3 group were significantly higher than those in the other groups. In addition, intragraft infiltration of CD3-, CD4-, CD8-, and CD68-positive cells was reduced in the ADSC 9 3 group. Furthermore, in the ADSC 9 3 group, the expression levels of proinflammatory cytokine interferon-gamma (IFN-c) were decreased and immunosuppressive prostaglandin E synthase (PGES) was increased in the xenograft and lymph node samples. CONCLUSION: This study presented that triple injections of ADSCs appeared to be superior to a single injection in suppressing cell-mediated xenograft rejection. The immunomodulatory effects of ADSCs are associated with the downregulation of IFN-c and upregulation of PGES in skin xenografts and lymph nodes.
Sang Wook Kim(김상욱),Mi Rang Lee(이미랑),Han Seok Kang(강한석),Seon Ku Kim(김선구),Teak Soon Shin(신택순),Hong Gu Lee(이홍구),Hae Yeal Jeon(전해열),Kwan Suk Kim(김관석),Chang Hee Do(도창희),Bong Hwan Choi(최봉환),Tae Hun Kim(김태헌) 한국생명과학회 2008 생명과학회지 Vol.18 No.6
돼지 2번 염색체의 육질 관련 양적 경제형질에 관한 연구보고가 몇몇 이루어 지고 있다. 양돈업계에서 DNA 기술을 이용한 염색체 정보를 활용하기 위해 본 연구에서는 13개의 후보 유전자에서 생성된 중합효소연쇄반응(PCR) 생성물을 비교 재서열 함으로써 단일염기변이(SNP) 표지들을 개발했다. 11개의 중합효소연쇄반응 생성물에서 296 bp마다 에서 평균 하나의 SNP, 총 34개의 SNP를 발견하였다. 또한 11개의 SNP에 대해 PCR 제한효소 길이 절편길이 다형성(RFLP) 분석을 전개한 후, 이를 대한민국 상업돈 4품종 개체군의 유전자형을 분석하는데 활용하였다. 본 연구는 유용한 단일염기변이를 식별하고 돼지 개체군 내 경제적으로 중요한 특성들과 SNP의 연관성을 확인하는 데 그 목적이 있다. Several studies reported quantitative trait loci (QTL) for meat quality on porcine chromosome 2. For application of the chromosomal information to pig industry through using DNA technology, single nucleotide polymorphism (SNP) markers are developed by comparative re-sequencing of polymerase chain reaction (PCR) products of 13 candidate genes. A total of 34 SNPs were identified in 11 PCR products, an average of one SNP in every 296 bp.PCR restriction fragment length polymorphism (RFLP) assays were developed for 11 SNPs and used to genotype four commercial pig populations in Korea. The SNP markers were used to map candidate genes in QTL and to clarify the relevance of SNP and quantitative traits.
Characteristic Control of Ru/CeO₂ Catalyst Using Carbon Coating for Low Pressure Ammonia Synthesis
Jae-Rang Youn(윤재랑),Min-Jae Kim(김민재),Seung-jae Lee(이승재),In-Soo Ryu(유인수),Mincheol Kim(김민철),Woohyun Kim(김우현),Kang Hee Cho(조강희),Hyung-chul Yoon(윤형철),Sang Goo Jeon(전상구) 한국에너지기후변화학회 2023 한국에너지기후변화학회 학술대회 Vol.2023 No.5
김상헌(Sang-Hun Kim),김광연(Kwang-Youn Kim),유선녕(Sun-Nyoung Yu),진영랑(Young Rang Jin),전현주(Hyun-Joo Jeon),이창민(Chang-Min Lee),안순철(Soon-cheol Ahn) 한국생명과학회 2011 생명과학회지 Vol.21 No.11
Silibinin은 milk thistle에서 분리된 주된 생리활성 성분으로 강력한 항산화제, 항암활성에 대해서 보고되어 있다. 하지만 항암활성에 대한 정확한 기전에 대해서는 밝혀져 있지 않다. 본 연구에서는 인간 전립선 암세포주인 PC-3 세포를 이용하여 세포사멸의 기전을 조사하였다. MTT assay를 통해 세포독성을 확인하였고, PI 염색을 통해 세포주기를 확인하고, Annexin-V/PI 염색을 통한 세포사멸을 확인하였다. 뿐만 아니라 western blot을 이용하여 세포주기 및 세포사멸에 관련된 단백질 발현 정도를 확인하였다. 본 연구의 결과에서 silibinin은 인간 전립선 암세포주인 PC-3 세포에서 세포주기관련 단백질의 발현을 조절하여 세포주기 진행을 억제함으로써 세포사멸을 유도 함을 알 수 있었다. Milk thistle (silybum marianum) is a famous dietary supplement widely used in the United States and Europe. Silbinin is a major biologically active compound of milk thistle and has strong antioxidant and radical scavenger activities. Anticancer activities, as well as chemopreventive effects on various cancer cell lines, including prostate, lung, colon, skin, and bladder, have also been reported in silbinin. In the present study, we investigated the anticancer effects of silibinin and apoptosis through cell cycle arrest on prostate cancer cell PC-3. We performed cell viability by MTT assay and western blotting to confirm cell cycle check point proteins such as cyclin A/D1/E and cyclin-dependent kinase (CDK) 2/4/6. To quantify silibinin-induced apoptotic cell death of PC-3, Annexin V and PI double staining was performed by flow cytometry, by which its cell distribution was determined. As a result, silibinin inhibited the cell growth of PC-3 cells in a time- and dose-dependent manner, and its treatment resulted in cell cycle arrest at the G1 phase. Also the level of cell cycle check point proteins (cyclin, CDK) was decreased by silibinin in a dose-dependent manner. Taken together, we suggest that apoptosis of prostate cancer cell line PC-3 induced by silibinin is associated with cell cycle arrest through decrease of cell cycle check point proteins, caspase-3 activation and poly (ADP-ribose) polymerase (PARP) cleavage.
지상파 MMS 가변 비트율 모드 방송에서 TV 채널 전환 시 발생하는 영상 표출 시간 지연의 개선
박성환(Sung-hwan Park),장해랑(Hae-rang Chang),전형준(Hyoung-joon Jeon),권순철(Soon-chul Kwon),이승현(Seung-hyun Lee) 한국디지털콘텐츠학회 2015 한국디지털콘텐츠학회논문지 Vol.16 No.5
EBS started 2HD MMS experimental broadcasting for the first time in Korea on Feb. 11, 2015. It uses the picture compression technique based on MPEG-2 CODEC, and applies the result of the experiment about variable bit rates and changes according to the scanning types, 1080i and 720p. But when changing channels, the delay in displaying picture occurs because of the operation of the variable GOP on MMS broadcasting, which optimizes image quality by application variable bit rates. In this study, verified the relationship between the decoding time of I frames and the GOP set in the encoding step by experimenting and analyzing ON-AIR TS. By using the verification data and adjusts the Encoder GOP parameters, improved the different video display time delays according to the scanning mode 1080i and 720p.
A comparison of the Glidescope^Ⓡ to the McGrath^Ⓡ videolaryngoscope in patients
Woo Jae Jeon,Kyoung Hun Kim,Jong Hoon Yeom,Mi Rang Bang,Jin-Bum Hong,Sang Yun Cho 대한마취통증의학회 2011 Korean Journal of Anesthesiology Vol.61 No.1
Background: The Glidescope^Ⓡ videolaryngoscope is a new device for tracheal intubation that provides an improved view of the larynx. This study was performed to compare the Glidescope with the McGrath videolaryngoscope in terms of time to intubation (TTI) and number of attempts. Methods: Patients were randomly allocated to one of two groups, Glidescope or McGrath group, by using computergenerated numbers. Tracheal intubation was attempted by an anesthesiologist with extensive experience using these two devices. The operator recorded ease of visualization of glottic structures based on the classification described by Cormack and Lehane. Number of failures, number of attempts and their duration, total intubation time, and events during the whole procedure were recorded. The duration of one attempt was defined as the time elapsed between picking up the endotracheal tube and verification of tracheal intubation with visualization of three expiratory carbon dioxide waveforms. TTI was defined as the sum of the duration of all intubation attempts (as many as three),excluding preoxygenation procedures. Results: TTI was significantly shorter for the Glidescope^Ⓡ compared to the McGrath^Ⓡ laryngoscope (40.5 vs. 53.3 s,respectively, P < 0.05). However, glottic views obtained at intubation were similar between the two groups. Number of intubation attempts was not significantly different between the two groups (1.03 ± 0.19 vs 1.10 ± 0.32, respectively)(mean ± SD). Conclusions: Study results demonstrated that the Glidescope reduced total intubation time in comparison with the McGrath, in terms of TTI in patients with normal airways.