http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
마우스 비장세포에서의 Polychlorinated Biphenyls(Aroclor 1234)의 면역 독성
반상자(Sang Ja Ban),안광수(Kwang Soo Ahn),김주환(Ju Hwan Kim),임종준(Jong Jun Lim),김수연(Soo Yeun Kim),기미경(Mee Kyung Kee),이명숙(Myoung Sook Lee),조수열(Soo Yeul Cho),김영훈(Young Hoon Kim),김지윤(Ji Yoon Kim),이유경(Yoo Kyoung L 한국독성학회 2003 Toxicological Research Vol.19 No.4
Polychlorinated biphenyls (PCBs) has been widely used as plasticizer, insulator, lubricant, paint and ink. The persistence of PCBs in the environment and their bioaccumulation in living<br/> organism make a raise concerns regarding their toxic effects in immune system and subsequent effects on human health. However little has been known about effect of PCB, an endocrine disrupter,<br/> on splenocytes. In this study, for identifying the effect on the organs and immune cell of mice by the concentration and time of commercial PCB mixture (Aroclor 1254), each 3 mice were tested at the concentration of 3, 30, 300, 1,000 mg/kg respectively, and their organ's weight were measured in 4, 7, 14 days, respectively. Also according to concentration and time, PCB was evaluated for the effects on splenocyte viability and lipopolysaccaride (LPS) and concanavaline A (Con A)-induced splenocyte proliferation on mice spleen. In liver and lung, there were significantly defferent by concentration and time of PCB (p<0.0001). In respect of concentration of PCB, no significant effects on mice's liver by Aroclor 1254 concentration below than 300 mg/kg were observed except at the concentration of 1,000 mg/kg doses (p<0.0001). But there was not significant different change in mice spleen by concentration and time of PCB (p=0.2206) and the mode of weight change of spleen was different to of liver and of lung. Viabilities of splenocytes were decreased following treatment with high concentration of PCB. Also, LPS and Con A-induced cell proliferations were decreased by Aroclor 1254 at 1,000 mg/kg. These data suggest that Aroclor 1254 is the immunotoxic compound that may have an effect on mouse immune system.
현대건축에서 구조와 표피 일체화 유형의 건축적 표현특성
이상호(Lee, Sang-Ho),반자연(Ban, Ja-Yuen) 한국실내디자인학회 2016 한국실내디자인학회논문집 Vol.25 No.4
This study tries to categorize trends of “structure and skin integration” and understand the expressive characters of each architectural type. To do so, we listed up 8 architects who are quoted twice or more in related researches, then analyzed their 25 contemporary buildings which integrated structure and skin since 2000. As a result, this study defined four types based on the way of building tectonic system of structure and skin. Key feature of “linear structure-two dimensional skin” type is the communication with the surroundings as a result of .geometric architectural forms, patterned surface and reflection. Characters of “linear-three dimensional” type are organic architectural forms, sculptural skin, and the mysterious space. “Planar-two dimensional” type is a transformational geometry form to express the dramatic images through the skin, therefore gives a sense of rhythm and dynamics to space. “Planar structure-three dimensional” type highlights the texture, and exposes boundary of the inside and outside. In architectures we studied, the structure is the way to make a creative forms and space, and the skin to express various meanings. That said, the “structure and skin integration” is the means of aggressive design expression.
구조와 표피가 일체화된 현대건축의 유형과 공간감에 관한 연구
이상호(Lee, Sang-Ho),반자연(Ban, Ja-Yuen) 한국실내디자인학회 2017 한국실내디자인학회논문집 Vol.26 No.1
The purpose of this study is to investigate the possibilities of architectural planning and expression of the relationship between structure and skin in contemporary architecture. For this purpose, we show interior space images -integration of structure and skin architecture- to students and experts of the related majors, and let them mark their feeling on the questionnaire composed spatial expression vocabulary extracted through the literature study on spatial sensibility, and analysis data. As a result, in contemporary architecture where the structure and the skin are integrated, form elements have a stronger influence on formation of space sense than elements of light and size, and aesthetics, characteristic, and temporality are common in the inner space, Three types of four types showed unique characteristics, and it was confirmed that there is a causal relationship between the spatial feeling factor and the spatial feeling. This means that the relationship between the structure and the skin can be considered as a planning factor, and this study is expected to be used as such basic data.
정상규,전숙자,반영운,박준영,Jeong, Sang-kyu,Jeon, Sook-ja,Ban, Yong-un,Park, Joon-young 한국토지주택공사 토지주택연구원 2021 LHI journal of land, housing, and urban affairs Vol.12 No.2
This study aims to understand the thematic trends globally developed in the 'Green Urbanism' related research. Research methodology is based on systemic review of international literature published for the past 20 years period between 2000 and 2020. The specific methods applied include not only literature search by citation, co-authorship, and co-occurrence but social network analysis in order to find correlations among the publication. The correlations are visualized and analysed using VOSviewer and Ucinet software. The analysis indicates that total of 51 studies were carried out by 89 authors from 54 institutions across 21 countries during the period. The majority of the research was done by a country-specific study and only a few research were collaborative studies with other countries. The most common theme that occurred in the early years was 'sustainability and the theme evolved toward specific ones such as 'built environment', 'infrastructure', and 'health'. Having considered that climate change has become a global challenge, green urbanism is expected to be a future direction to pursue environmentally sustainable urban spaces. This study also implies that governance, policy support, and intervention are crucial factors in developing sustainable urban spaces. 도시 계획 의사 결정 과정에서 그린 어바니즘의 원리를 적용하기 위해 이 연구는 그린 어바니즘에 대한 국제 연구들의 동향과 주요 화제를 규명하였다. 이 연구는 2000년부터 2020년까지 국제학계에 발표된 그린 어바니즘 연구 문헌들을 전수 조사하였다. 연구 문헌들의 서지 정보 간의 관계를 파악하기 위해 인용, 공동저술, 동시출현 분석법과 소셜 네트워크 분석법(SNA)과 같은 분석방법들이 활용되었다. 이러한 관계들은 VOSviewer와 Ucinet 소프트웨어를 통해 가시화되고 분석되었다. 국제학계에서 2000년부터 2020년까지 21개국 54개 기관들에서 그린 어바니즘 연구들이 수행되었으나 연구 성과물들은 그리 많지 않았고 거의 모든 성과들이 공동 연구보다는 개별 연구를 통해 얻어졌다. 그린 어바니즘의 최고 화제는 "지속가능성"이었다. 이와 관련하여 초기에 피상적이었던 화제들이 점차적으로 건조환경, 기반시설, 건강 등과 같이 구체적인 화제들로 변화되었다. 지속가능성을 추구하는 국제적 동향에 따라 그린 어바니즘은 환경적으로 지속 가능한 도시 공간을 실현할 수 있는 해법이 될 것으로 기대한다. 이러한 비전의 실현과정에서 거버넌스의 중재와 정책적 지원이 중요한 역할을 하는 것으로 추론되었다. 따라서 향후에 이러한 화제들과 관련된 지속 가능한 도시 계획을 위한 의사결정 모델 개발이 필요하다.
Evaluation of Haemagglutinin Content by RP-HPLC to Generate Pandemic Influenza Vaccine
Kang, Hyunkyung,Roh, Hang Sik,Song, Hyemin,Lee, Kwangmoon,Chung, Seung-Tae,Ban, Sang-ja,Mo, In Pil,An, Beum-Soo,Ahn, Chi-Young Korean Society of ToxicologyKorea Environmental Mu 2016 Toxicological Research Vol.32 No.4
The potency of influenza vaccine is determined based on its hemagglutinin (HA) content. In general, single radial immunodiffusion (SRID) assay has been utilized as the standard method to measure HA content. However, preparation of reagents for SRID such as antigen and antibody takes approximately 2~3 months, which causes delays in the development of influenza vaccine. Therefore, quantification of HA content by other alternative methods is required. In this study, we measured HA contents of H1N1 antigen and H1N1 influenza vaccine by reverse phase-high performance liquid chromatography (RP-HPLC) methods. The presence of HA1 and HA2 was investigated by silver staining and Western blot assay. In addition, accuracy and repeatability of HA measurement by RP-HPLC were evaluated. Comparison of HA concentration by SRID and RP-HPLC revealed a precise correlation between the two methods. Our results suggest that RP-HPLC assay can replace SRID in the event of a pandemic flu outbreak for rapid vaccine development.
Evaluation of Haemagglutinin Content by RP-HPLC to Generate Pandemic Influenza Vaccine
Hyunkyung Kang,Hang Sik Roh,Hyemin Song,Kwangmoon Lee,Seung-Tae Chung,Sang-ja Ban,In Pil Mo,Beum-Soo An,Chi-Young Ahn 한국독성학회 2016 Toxicological Research Vol.32 No.4
The potency of influenza vaccine is determined based on its hemagglutinin (HA) content. In general, single radial immunodiffusion (SRID) assay has been utilized as the standard method to measure HA content. However, preparation of reagents for SRID such as antigen and antibody takes approximately 2~3 months, which causes delays in the development of influenza vaccine. Therefore, quantification of HA content by other alternative methods is required. In this study, we measured HA contents of H1N1 antigen and H1N1 influenza vaccine by reverse phase-high performance liquid chromatography (RP-HPLC) methods. The presence of HA1 and HA2 was investigated by silver staining and Western blot assay. In addition, accuracy and repeatability of HA measurement by RP-HPLC were evaluated. Comparison of HA concentration by SRID and RP-HPLC revealed a precise correlation between the two methods. Our results suggest that RP-HPLC assay can replace SRID in the event of a pandemic flu outbreak for rapid vaccine development.