한국 남성 동성애자들의 성행태와 후천성면역결핍증에 대한 인식

기미경,박철민,장창곡,고운영,Kee, Mee-Kyung,Park, Chul-Min,Chang, Chang-Gok,Go, Un-Yeong 대한예방의학회 2004 예방의학회지 Vol.37 No.3

Objectives : To investigate the sexual behavioral characteristics and HIV/AIDS knowledge among men who have sex with men(MSM), one of the HIV high risk groups. Methods : A three month survey among individuals who were able to be contacted was carried out over the entire Republic of Korea, between May and August, 2001. 348 individuals completed a self-administered question-naire. The data collected included demographic informa-tion, sexual behavior and AIDS knowledge. Results : Eighty-seven and ninety-two per cent of the 348 MSM were aged 20-39 years and had never been married, respectively. Fifty-five per cent of participants reported at least one sexual contact with women, and a quarter of the MSM surveyed had engaged in high-risk sexual behavior (more than 6 partners) during the previous year. About twenty per cent of the MSM had anal sex as their favorite way of having sex, and seventy-four per cent did not use condoms regularly due to loss of enjoyment, and were more likely to be engaged in risky behaviors. Only ten per cent had a regular HIV test history, and most had obtained knowledge or information on HIV/AIDS through the mass media. Conclusions : A large proportion of the MSM in Korea still remain at an elevated risk for contracting HIV infection. Change in high-risk sexual behaviors will prevent the spread of HIV infection among the MSM population, which requires public health education for preventive interventions, and should be culturally and socially specific in order to be effective.

이성간 성접촉을 통한 HIV 전파율과 위험인자에 관한 연구: 남성으로부터 여성으로의 전파

고운영,기미경,최병선,강춘,도경미,이주현,이주실,Go, Un-Yeong,Kee, Mee-Kyung,Choi, Byeong-Sun,Kang, Chun,Do, Kyoung-Mee,Lee, Ju-Hyun,Lee, Joo-Shil 대한예방의학회 1999 예방의학회지 Vol.32 No.2

Objectives: Despite the importance of human immunodeficiency virus(HIV) transmission through heterosexual contact, the features of heterosexual transmission has not been well studied in Korea. So we conducted a cross sectional study to determine the transmission rates in married couples and assess risk factors for male to female heterosexual transmission of HIV. Methods: 169 HIV-infected males and their female sex partners were recruited from 1985 to tune 1998. We examined female sex partner's HIV infection status and interviewed male index partners and their female sex partners about demographic characteristics and sexual practices. We analysed heterosexual transmission rate by epidemiologic characteristics, disease status and sexual practices. And we assessed risk factors for HIV infection by univariate and multivariate analysis. Results: 30 female sex partners were infected at enrollment, yielding an transmission rate of 17.8%. Among couples who had used condoms consistently, none of the female sex partners was infected with HIV. In univariate analysis the significant risk factors were full blown AIDS status (OR=4.1, 95% CI: 1.49-11.43) and low CD4 T cell count of index partners at enrollment (OR=7.8, 95% CI: 2.19-27.80). In multivariate analysis HIV-1 RNA levels was significant risk factor when adjusted by CD4 T cell courts and mean sexual contacts per month (OR=19.2, 95% CI: 1.03-357.59) Conclusion: The risk of male to female heterosexual transmission increased with advanced stages of HIV infection in the index male partners.

후향연산 모형 (Back-calculation model)을 이용한 국내 HIV 감염자와 AIDS 환자의 추계

이주영,고운영,기미경,김지연,황진수,Lee, Ju-Young,Goh, Un-Yeong,Kee, Mee-Kyung,Kim, Jee-Yun,Hwang, Jin-Soo 대한예방의학회 2002 Journal of Preventive Medicine and Public Health Vol.35 No.1

Objective : To estimate the status of HIV infection and AIDS incidence using a back-calculation model in Korea. Methods : Back-calculation is a method for estimating the past infection rate using AIDS incidence data. The method has been useful for obtaining short-term projections of AIDS incidence and estimating previous HIV prevalence. If the density of the incubation periods is known, together with the AIDS incidence, we can estimate historical HIV infections and forecast AIDS incidence in any time period up to time t. In this paper, we estimated the number of HIV infections and AIDS incidence according to the distribution of various incubation periods Results : The cumulative numbers of HIV infection from 1991 to 1996 were $708{\sim}1,426$ in Weibull distribution and $918{\sim}1,980$ in Gamma distribution. The projected AIDS incidence in 1997 was $16{\sim}25$ in Weibull distribution and $13{\sim}26$ in Gamma distribution. Conclusions : The estimated cumulative HIV infections from 1991 to 1996 were $1.4{\sim}4.0$ times more than notified cumulative HIV infections. Additionally, the projected AIDS incidence in 1997 was less than the notified AIDS cases. The reason for this underestimation derives from the very low level of HIV prevalence in Korea, further research is required for the distribution of the incubation period of HIV infection in Korea, particularly for the effects of combination treatments.

마우스 비장세포에서의 Polychlorinated Biphenyls(Aroclor 1234)의 면역 독성

반상자(Sang Ja Ban),안광수(Kwang Soo Ahn),김주환(Ju Hwan Kim),임종준(Jong Jun Lim),김수연(Soo Yeun Kim),기미경(Mee Kyung Kee),이명숙(Myoung Sook Lee),조수열(Soo Yeul Cho),김영훈(Young Hoon Kim),김지윤(Ji Yoon Kim),이유경(Yoo Kyoung L 한국독성학회 2003 Toxicological Research Vol.19 No.4

Polychlorinated biphenyls (PCBs) has been widely used as plasticizer, insulator, lubricant, paint and ink. The persistence of PCBs in the environment and their bioaccumulation in living<br/> organism make a raise concerns regarding their toxic effects in immune system and subsequent effects on human health. However little has been known about effect of PCB, an endocrine disrupter,<br/> on splenocytes. In this study, for identifying the effect on the organs and immune cell of mice by the concentration and time of commercial PCB mixture (Aroclor 1254), each 3 mice were tested at the concentration of 3, 30, 300, 1,000 mg/kg respectively, and their organ's weight were measured in 4, 7, 14 days, respectively. Also according to concentration and time, PCB was evaluated for the effects on splenocyte viability and lipopolysaccaride (LPS) and concanavaline A (Con A)-induced splenocyte proliferation on mice spleen. In liver and lung, there were significantly defferent by concentration and time of PCB (p<0.0001). In respect of concentration of PCB, no significant effects on mice's liver by Aroclor 1254 concentration below than 300 mg/kg were observed except at the concentration of 1,000 mg/kg doses (p<0.0001). But there was not significant different change in mice spleen by concentration and time of PCB (p=0.2206) and the mode of weight change of spleen was different to of liver and of lung. Viabilities of splenocytes were decreased following treatment with high concentration of PCB. Also, LPS and Con A-induced cell proliferations were decreased by Aroclor 1254 at 1,000 mg/kg. These data suggest that Aroclor 1254 is the immunotoxic compound that may have an effect on mouse immune system.

한국에서의 1999년도 삼일열 말라리아 발생현황

박재원,황보영,손정일,허준평,정현순,이상원,기미경 대한감염학회 2000 감염 Vol.32 No.4

HIV 감염자에서 CD4+T 림프구수, β₂-Microglobulin 및 HIV p24 항원

조영걸,신영오,최병선,김태숙,허숙진,기미경,김성순,강춘,조양자,김영봉,조군제 대한감염학회 1993 감염 Vol.25 No.2

We have measured CD4+T lymposite , β²-MG) and p24 antigen level in 188 HIV patients Estimated duration presumptive HIV inpection last tested CD4+T lymphocyte counting was 55.2±23 months in group with Zidovudine (Acidothymidine, AZT) treatment(Tx) and 38.4±20 months in group without AZT. There was no CD4+T lymphocyte of less than 400/mm³in 56 normal persons but 46% (86) were CD4+T lymphocyte of less than 400/mm³in 188 HIV patients. Annual decrase of CD4+T lymphocyte counts was 70/mm³in group without AZT tx and 38/mm³in group with AZT tx months after tx start. In the distribution of serum β₂-MG level in 182 HIV patients and 48 normal control, 90% (43) of control were below 2.0 mg/L and 76%(139) of HIV patients were over 2.0mg/L (p=0). β₂-MG level was negatively correlated with CD4+T lymphocyte (r=-0.394,<0.001). HIV p24 core antigen was detected in 26 (14.9%) out of 174 HIV/AIDS patients. Of the 26 patients, 21(81%) were CD4+T lymphocyte of less than 400/mm³and 46% (12) of less than 200/mm³. In was confirmed that 3 tests mentioned above are useful markers for prognosis of HIV infected persons.