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Essential roles of bile acid receptors FXR and TGR5 as metabolic regulators
Sandra Jacinto,황성순 한국통합생물학회 2014 Animal cells and systems Vol.18 No.6
Alterations of bile acid (BA) metabolism in type II diabetes (T2D) have revealed a link between BAs and metabolichomeostasis. The BA receptors farnesoid X receptor (FXR) and G-protein coupled BA receptor 1 (TGR5) both have shownto regulate lipid, glucose, and energy metabolism, rendering them potential therapeutic targets for T2D therapy. Astonishingly, BA signaling is vital as it has known to be a positive factor for beneficial improvements in vertical sleevegastrectomy surgery, in turn making these BA receptors beneficial tools in therapeutic targets for T2D. These metabolicregulators: FXR and TGR5 are essential modulators in the metabolic system, which affect the human machinery and will bethe focus of this review.