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      • Cardiovascular Fitness and Associated Comorbidities in An Executive Health Program

        Otto A Sanchez(Otto A Sanchez ),Anton S. Hesse(Anton S. Hesse ),Morgan R. Betker(Morgan R. Betker ),Christopher J. Lundstrom(Christopher J. Lundstrom ),William E. Conroy(William E. Conroy ),Zan Gao(Za 사피엔시아 2022 Exercise Medicine Vol.6 No.-

        Objectives: Low cardiorespiratory fitness, defined as a VO2 max below the 25th percentile for age and sex, is associated with greater body mass index (BMI), blood pressure, and plasma cholesterol values and is an independent risk factor for cardiovascular and metabolic diseases. Given that sedentarism has substantially increased in the U.S. population in the last 20 years and that office workers have the lowest cardiorespiratory fitness of the workforce, we aimed to assess the prevalence of low cardiorespiratory fitness in an corporate wellness program and determine its relationship with associated comorbidities. Methods: For this retrospective observational analysis demographics, height, weight, blood pressure at rest, plasma glucose, lipids, comorbidities, and VO2 max data was extracted from the medical records of 199 participants attending the Executive Health Program at M Health Fairview of the University of Minnesota. Participants were predominantly white, middle-aged men with near-optimal blood pressure values. Results: Participants with low cardiorespiratory fitness had a VO2 max [mean (range) of 28 (19.4 - 36.1) mL/kg/min], and was observed in 33% of all participants. Participants with low cardiorespiratory fitness were more likely to have higher BMI, dyslipidemia and hypertension than those in the excellent to superior category of cardiorespiratory fitness, VO2 max [mean (range) 45.6 (31.8 - 61.2) mL/kg/min]. Prevalence of obesity (17%) was lower than in the general U.S. population, and those who were obese were more likely to be of low cardiorespiratory fitness. Those with low cardiorespiratory fitness had a four fold relative risk of belonging to the group at high risk of cardiovascular and metabolic diseases when compared to those with a fair to superior cardiorespiratory fitness. Conclusions: Low cardiorespiratory fitness identified in a third of all participants, is a modifiable risk factor associated with risk for cardiovascular and metabolic disease, should be evaluated in executive health programs.

      • SCOPUSKCI등재

        Caudal Neuromodulation with the Transforaminal Sacral Electrode (InterStim<sup>Ⓡ</sup>): Experience in a Pain Center Regarding 12 Implants

        Guardo, Laura Alonso,Gala, Carlos Cano,Poveda, David Sanchez,Juan, Pablo Rueda,Sanchez Montero, Francisco Jose,Garzon Sanchez, Jose Carlos,Lamas, Juan Ignacio Santos,Sanchez Hernandez, Miguel Vicente The Korean Pain Society 2016 The Korean Journal of Pain Vol.29 No.1

        Background: Sacral nerve stimulation is a therapeutic option with demonstrated efficacy for conditions presenting with perineal pain caused by different etiologies. We aimed to assess whether a sacral electrode ($Interstim^{(R)}$, Medtronic, Minneapolis, MN, USA) inserted through the caudal pathway is able to offer an acceptable level of sacral stimulation and rate of catheter migration. Methods: We present 12 patients with pelvic pain who received sacral neuromodulation via the sacral hiatus with the InterStim electrode. We evaluated patient satisfaction as well as migration and removal of the electrode, if necessary. Results: Our experience included 12 patients, 10 women and two men, with a mean age of 60 years. In eight of the 12 patients, the initial therapy was effective, and the final system implantation was performed. During subsequent follow-up, patient satisfaction was good. To date, there have been no cases of electrode displacement or migration. Conclusions: The caudal insertion of the InterStim electrode, with its own fixation system, and initially designed for transsacral insertion, appears in our experience to be a satisfactory option which can minimize electrode displacements, achieving similar results in therapeutic efficacy and causing no difficulties in removal.

      • KCI등재

        On the use of time-dependent success criteria within Risk-Informed Analyses. Application to LONF-ATWS sequences in PWR reactors

        Sanchez-Torrijos Jorge,Queral Cesar,Paris Carlos,Rebollo Maria Jose,Sanchez-Perea Miguel,Posada Jose Maria 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.12

        The classical Probabilistic Safety Analysis (PSA) does not include any time dependence explicitly. However, the success criteria (SC) could evolve during the cycle for some initiating events. In that sense, there is a type of sequence in which this time-dependency is quite important, the family of Anticipated Transient without Scram (ATWS) sequences in Pressurized Water Reactors. Therefore, a new riskinformed approach is proposed in this paper, which makes it possible to obtain the time-dependent SC evolution of the safety functions affected by the Moderator Temperature Coefficient (MTC) value. Then, the evolution of the ATWS conditional core damage probability (CCDP) could be obtained using a PSA model. To quantify the CCDP, the average values of the time-dependent failure probabilities must be computed. Finally, the comparison between the CCDP obtained through the application of the classical PSA approach and the new one makes it possible to quantify the impact of time-dependence on the SC of the headers that this new risk-informed ATWS approach can provide.

      • Gene Expression of CYP1A1 and its Possible Clinical Application in Thyroid Cancer Cases

        Gallegos-Vargas, JA,Sanchez-Roldan, J,Ronquillo-Sanchez, MD,Carmona-Aparicio, L,Floriano-Sanchez, E,Cardenas-Rodriguez, N Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7

        Background: Thyroid cancer is the most common endocrine malignancy, and exact causes remain unknown. The role of CYP450 1A1 (CYP1A1) in cancer initiation and progression has been investigated. The aim of this work was to analyze, for the first time, CYP1A1 gene expression and its relationship with several clinicopathological factors in Mexican patients diagnosed with thyroid cancer. Materials and Methods: Real-time PCR analysis was conducted on 32 sets of thyroid tumors and benign pathologies. Expression levels were tested for correlations with clinical and pathological data. All statistical analysis were performed using GraphPad Prism version 3.0 software. Results: We found that female gender was associated with thyroid cancer risk (P<0.05). A positive relationship was identified between CYP1A1 mRNA levels and the presence of chronic disease, alcohol use, tumor size, metastasis and an advanced clinical stage (P<0.05). Conclusions: The results suggest that CYP1A1 gene expression could be used as a marker for thyroid cancer.

      • KCI등재

        Use of natural ingredients in Japanese quail diet and their effect on carcass and meat quality — A review

        Rey David Vargas-Sanchez,Felix Joel Ibarra-Arias,Brisa del Mar Torres-Martinez,Armida Sanchez-Escalante,Gaston Ramon Torrescano-Urrutia 아세아·태평양축산학회 2019 Animal Bioscience Vol.32 No.11

        The present paper reviews the findings of different research studies on the effect of natural ingredients in the Japanese quail (Coturnix coturnix japonica) diet on carcass characteristics and meat quality. The results show a relationship between the type and concentration of ingredients used in diets and carcass characteristics and meat quality. The inclusion of medicinal herbs (thyme, black seed, and mint), plants (canola), seeds (chickpea), spices (cinnamon and coriander), worms (earthworms), bee products (propolis), phytochemicals (lycopene), and edible fungi (common mushrooms) in the diet improved carcass quality characteristics compared to the control diets (basal diets). The inclusion of medicinal herbs (spearmint and green tea), spices (cinnamon), vegetables (tomato), plants (verbena and canola), seeds (marijuana), and edible fungi (oyster mushrooms) improved meat quality. In conclusion, the use of ingredients of natural origin in the diet of Japanese quail improves carcass quality characteristics and meat quality.

      • SCOPUSKCI등재

        Caudal Neuromodulation with the Transforaminal Sacral Electrode (InterStimⓡ): Experience in a Pain Center Regarding 12 Implants

        ( Laura Alonso Guardo ),( Carlos Cano Gala ),( David Sanchez Poveda ),( Pablo Rueda Juan ),( Francisco Jose Sanchez Montero ),( Jose Carlos Garzon Sanchez ),( Juan Ignacio Santos Lamas ),( Miguel Vice 대한통증학회 2016 The Korean Journal of Pain Vol.29 No.1

        Background: Sacral nerve stimulation is a therapeutic option with demonstrated efficacy for conditions presenting with perineal pain caused by different etiologies. We aimed to assess whether a sacral electrode (InterStimⓡ, Medtronic, Minneapolis, MN, USA) inserted through the caudal pathway is able to offer an acceptable level of sacral stimulation and rate of catheter migration. Methods: We present 12 patients with pelvic pain who received sacral neuromodulation via the sacral hiatus with the InterStim electrode. We evaluated patient satisfaction as well as migration and removal of the electrode, if necessary. Results: Our experience included 12 patients, 10 women and two men, with a mean age of 60 years. In eight of the 12 patients, the initial therapy was effective, and the final system implantation was performed. During subsequent follow-up, patient satisfaction was good. To date, there have been no cases of electrode displacement or migration. Conclusions: The caudal insertion of the InterStim electrode, with its own fixation system, and initially designed for transsacral insertion, appears in our experience to be a satisfactory option which can minimize electrode displacements, achieving similar results in therapeutic efficacy and causing no difficulties in removal. (Korean J Pain 2016; 29: 23-28)

      • Structure and optical properties of vapor grown In<sub>2</sub>O<sub>3</sub>: Ga nano-/microcrystals

        Sanchez, Diego Leon,Ramon, Jesus Alberto Ramos,Zaldivar, Manuel Herrera,Pal, Umapada,Rosas, Efrain Rubio Techno-Press 2015 Advances in nano research Vol.3 No.2

        Octahedral shaped single crystalline undoped and Ga-doped indium oxide nano-and microcrystals were fabricated using vapor-solid growth process. Effects of Ga doping on the crystallinity, defect structure, and optical properties of the nano-/microstructures have been studied using scanning electron microscopy, microRaman spectroscopy, transmission electron microscopy and cathodoluminescence spectroscopy. It has been observed that incorporation of Ga does not affect the morphology of $In_2O_3$ structures due to its smaller ionic radius, and similar oxidation state as that of In. However, incorporation of Ga in high concentration (~3.31 atom %) causes lattice compression, reduces optical band gap and defect induced CL emissions of $In_2O_3$ nano-/microcrystals. The single crystalline Ga-doped, $In_2O_3$ nano-/microcrystals with low defect contents are promising for optoelectronic applications.

      • Yaw motion analysis of a FPSO turret mooring system under wave drift forces

        Sanchez-Mondragon, J.,,zquez-Herná,ndez, A.O.,Cho, S.K.,Sung, H.G. Elsevier 2018 Applied ocean research Vol.74 No.-

        <P><B>Abstract</B></P> <P>In order to evaluate the dynamic behavior of a FPSO-turret system, experimental tests in engineering wave basin have been performed. During the realization of experimental test large slow yaw rotations were detected in the dynamic behavior of the vessel during regular and irregular wave conditions tests. In order to study this phenomenon, an analytical method was developed in order to predict the maximum yaw angle reached under the slow yaw varying oscillations of a single point moored FPSO-turret system dependent of the regular mean wave drift forces and the turret position. The results for the proposed analytical method were verified by comparing it with experimental and simulated results. Then, the proposed method allows to identify the critical regular wave periods than can provoke large yaw rotations as an alternative for the stability tests by bifurcation analysis. On the other hand, the performed yaw motion simulations take into account the following aspects: the turret position, and the force and momentum associated with the mooring system variations (in function of the FPSO center of gravity positions and regular mean wave drift forces). Analyzing the time domain simulations it is possible to identify that large yaw motion is reached faster when the turret is near the CG and so, as the turret moves away, the yaw motions become slower.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Analytical yaw stability condition is developed. </LI> <LI> FPSO-turret dynamic study under wave drift forces on regular wave conditions. </LI> <LI> Numerical simulations and experimental results compared the yaw stability condition. </LI> <LI> Turret position configuration variations associated with yaw instabilities. </LI> </UL> </P>

      • SCIESCOPUSKCI등재

        APOLLO2 YEAR 2010

        Sanchez, Richard,Zmijarevi, Igor,Coste-Delclaux, M.,Masiello, Emiliano,Santandrea, Simone,Martinolli, Emanuele,Villate, Laurence,Schwartz, Nadine,Guler, Nathalie Korean Nuclear Society 2010 Nuclear Engineering and Technology Vol.42 No.5

        This paper presents the mostortant developments implemented in the APOLLO2 spectral code since its last general presentation at the 1999 M&C conference in Madrid. APOLLO2 has been provided with new capabilities in the domain of cross section self-shielding, including mixture effects and transfer matrix self-shielding, new or improved flux solvers (CPM for RZ geometry, heterogeneous cells for short MOC and the linear-surface scheme for long MOC), improved acceleration techniques ($DP_1$), that are also applied to thermal and external iterations, and a number of sophisticated modules and tools to help user calculations. The method of characteristics, which took over the collision probability method as the main flux solver of the code, allows for whole core two-dimensional heterogeneous calculations. A flux reconstruction technique leads to fast albeit accurate solutions used for industrial applications. The APOLLO2 code has been integrated (APOLLO2-A) within the $ARCADIA^{(R)}$ reactor code system of AREVA as cross section generator for PWR and BWR fuel assemblies. APOLLO2 is also extensively used by Electricite de France within its reactor calculation chain. A number of numerical examples are presented to illustrate APOLLO2 accuracy by comparison to Monte Carlo reference calculations. Results of the validation program are compared to the measured values on power plants and critical experiments.

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