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Rizvi, Syed Zaki Husain,Shah, Fawad Ali,Khan, Namrah,Muhammad, Iftikhar,Ali, Khan Hashim,Ansari, Muhammad Mohsin,Din, Fakhar ud,Qureshi, Omer Salman,Kim, Kyoung-Won,Choe, Yeong-Hwan,Kim, Jin-Ki,Zeb, A Elsevier 2019 International journal of pharmaceutics Vol.560 No.-
<P><B>Abstract</B></P> <P>The objective of current study was to develop solid lipid nanoparticles-loaded with simvastatin (SIM-SLNs) and investigate their <I>in vivo</I> anti-hyperlipidemic activity in poloxamer-induced hyperlipidemia model. Nano-template engineering technique was used to prepare SIM-SLNs with palmityl alcohol as lipid core and a mixture of Tween 40/Span 40/Myrj 52 to stabilize the core. The prepared SIM-SLNs were evaluated for physicochemical parameters including particle diameter, surface charge, morphology, incorporation efficiency, thermal behaviour and crystallinity. <I>In vitro</I> release profile of SIM-SLNs in simulated gastric and intestinal fluids was evaluated by using dialysis bag technique and anti-hyperlipidemic activity was assessed in hyperlipidemia rat model. SIM-SLNs revealed uniform particle size with spherical morphology, zeta potential of −24.9 mV and high incorporation efficiency (∼85%). Thermal behaviour and crystallinity studies demonstrated successful incorporation of SIM in the lipid core and its conversion to amorphous form. SIM-SLNs demonstrated a sustained SIM release from the lipid core of nanoparticles. SIM-SLNs significantly reduced the elevated serum lipids as indicated by ∼3.9 and ∼1.5-times decreased total cholesterol compared to those of untreated control and SIM dispersion treated hyperlipidemic rats. In conclusion, SIM-SLNs showed a great promise for improving the therapeutic outcomes of SIM via its effective oral delivery.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Asiri, Abdullah M.,Khan, Salman A.,Al-Amoudi, Muhammed S.,Alamry, Kalid A. Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.6
Three carbazole chromophores featuring dicyano, cyano, ethyl acetate and dimethyl acetate groups as an acceptor moiety with a ${\pi}$-conjugated spacer and $N$-methyl dibenzo[$b$]pyrole as donor were synthesized by Knovenagel condensation and characterized by IR, $^1HNMR$, $^{13}CNMR$, UV-vis, fluorescence spectroscopy, electrochemistry and theoretical B3LYP/6-$311G^*$ level whilst NLO properties and spectroscopic quantities were calculated. Calculations showed remarkable trend with HOMO located on the donor moiety and LUMO on the acceptors dicyano methylene, cyano, ethyl acetate methylene and dimethyl acetate methylene. In agreement with the calculations, solvatochromic, behavior intramolecular charge transfer band was observed in the visible region.
Abdullah M. Asiri,Salman A. Khan,Muhammed S. Al-Amoudi,Kalid A. Alamry 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.6
Three carbazole chromophores featuring dicyano, cyano, ethyl acetate and dimethyl acetate groups as an acceptor moiety with a π-conjugated spacer and N-methyl dibenzo[b]pyrole as donor were synthesized by Knovenagel condensation and characterized by IR, 1HNMR, 13CNMR, UV-vis, fluorescence spectroscopy, electrochemistry and theoretical B3LYP/6-311G* level whilst NLO properties and spectroscopic quantities were calculated. Calculations showed remarkable trend with HOMO located on the donor moiety and LUMO on the acceptors dicyano methylene, cyano, ethyl acetate methylene and dimethyl acetate methylene. In agreement with the calculations, solvatochromic, behavior intramolecular charge transfer band was observed in the visible region.
Shuguang Li,M. Waqas,Salman A. AlQahtani,M. Ijaz Khan 한국자기학회 2023 Journal of Magnetics Vol.28 No.2
Enhancing heat transfer is of utmost importance in modern industrial applications. Pure liquids for illustration ethylene glycol, propylene glycol and water having lower conductivity are commonly used as cooling liquids in distinct applications. This approach helps conserve and optimize the enhancement of heat transportation. However, in order to achieve enhanced thermal efficiency, state-of-the-art liquids known as nanoliquids have been recommended. Thus the Buongiorno two-component nanoliquid model, which exhibits superior thermal efficiency compared to the aforementioned standard cooling liquids is being considered for formulating and analyzing the behavior of Casson nanoliquid configured by cylindrical convected surface. The problem formulation incorporates various factors such as Darcy-Forchheimer porosity, thermophoresis, magnetohydrodynamics, Brownian diffusion, suction/injection and Joule heating. Boundary-layer stretching flow is formulated. Dimensionless differential form from governing nonlinear problems is achieved by employing relevant variables. The application of the homotopy procedure results in convergent solutions for strongly nonlinear systems. The graphs are used to reveal the plots of significant factors in the analysis.