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        AIDS Awareness: Indispensible Prerequisite Among Fishermen Population

        Swapna B. Shetty,Darshan D. Divakar,M.H.N. Dalati,Sajith Vellappally,Sukumaran Anil,Marey A. Alshehry,Baher Felemban,Al S. Mamdouh,Obaid A. Alshahrani 질병관리본부 2016 Osong Public Health and Research Persptectives Vol.7 No.5

        Objectives: Fishermen are among the most vulnerable groups for human immunodeficiency virus (HIV)/AIDS with reported high prevalence. Poor knowledge base has been evidenced by a few studies. The present study was conducted to assess the knowledge regarding HIV/AIDS among fishermen of the Kutch coast, Gujarat, India. Methods: A descriptive cross-sectional study was conducted among 950 fishermen of the Kutch coast, in the months of January-February 2015. Knowledge of HIV/AIDS of fishermen was assessed using structured interview schedules with 12 questions. The information on socio-demographic characteristics was also obtained. Chi-square test and multivariate logistic regression analysis were used for statistical analysis. The confidence level and level of significance were fixed at 95% and 5%, respectively. Results: A major proportion of participants (57.2%) had no access to any potential source of information and had never heard about HIV/AIDS (65.1%). Some of them were aware of modes of transmission of AIDS but only a few of them knew about the methods of prevention. Only 23.1% of participants were observed with appropriate knowledge regarding HIV/AIDS. Bivariate and multivariate analysis revealed significant variation in the proportion of participants with appropriate knowledge with age and educational status.

      • Association of Poly (ADP-Ribose) Polymerase 1 Variants with Oral Squamous Cell Carcinoma Susceptibility in a South Indian Population

        Anil, Sukumaran,Gopikrishnan, PB,Basheer, Ashik Bin,Vidyullatha, BG,Alogaibi, Yahya A,Chalisserry, Elna P,Javed, Fawad,Dalati, MHN,Vellappally, Sajith,Hashem, Mohamed Ibrahim,Divakar, Darshan Devang Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.8

        Background: Oral cancers account for approximately 2% of all cancers diagnosed each year; however, the vast majority (80%) of the affected individuals are smokers whose risk of developing a lesion is five to nine times greater than that of non-smokers. Tobacco smoke contains numerous carcinogens that cause DNA damage, including oxidative lesions that are removed effectively by the base-excision repair (BER) pathway, in which poly (ADP-ribose) polymerase 1 (PARP-1), plays key roles. Genetic variations in the genes encoding DNA repair enzymes may alter their functions. Several studies reported mixed effects on the association between PARP-1 variants and the risk of cancer development. Till now no reported studies have investigated the association between PARP-1 variants and oral squamous cell carcinoma (OSCC) risk in an Indian population. Materials and Methods: In the present case control study 100 OSCC patients and 100 matched controls were genotyped using PARP1 single nucleotide peptides (SNP's) rs1136410 and rs3219090 using TaqMan assays. Results: The results indicated significantly higher risk with PARP1 rs1136410 minor allele "C" (OR=1.909; p=0.02942; CI, 1.060-3.439). SNP rs1136410 also showed significantly increased risk in patients with smoking habit at C/C genotype and at minor allele C. Conclusions: The PAPR-1 Ala762Val polymorphism may play a role in progression of OSCC. Larger studies with a greater number of samples are needed to verify these findings.

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