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Saitou, Marie,Ishida, Takafumi Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.1
Background: Deletion types of genetic variants of glutathione S-transferase (GST) M1 and T1, the GSTM1 null and GSTT1 null which are risk factors for certain cancers, have been ubiquitously found in human populations but their worldwide distribution pattern is unclear. Materials and Methods: To perform a meta-analysis, a systematic search for the literature on GSTM1 and GSTT1 null genotypes was done to identify 63 reports for 81 human populations. Relationships between the GSTM1 and GSTT1 null genotype frequencies and the absolute latitude of 81 populations were tested by Spearman's rank correlation coefficient. Results: A significant positive correlation was detected between the GSTM1 null genotype frequency and the absolute latitude (r=0.28, p-value <0.05), whereas the GSTT1 null genotype frequency and absolute latitude showed a significant negative correlation (r= -0.41 p-value <0.01). There was no correlation between the frequencies of GSTM1 and GSTT1 null genotype in each population (r= -0.029, p-value=0.80). Conclusions: Latitudinal clines of the distribution of the GSTM1 and GSTT1 null genotypes may be attributed to the result of gene-environmental adaptation. No functional compensation between GSTM1 and GSTT1 was suggested by the lack of correlation between the null frequencies for GSTM1 and GSTT1.
Design of Heat-Activated Reversible Integral Attachments for Product-Embedded Disassembly
Li, Ying,Kikuchi, Noboru,Saitou, Kazuhiro Society for Computational Design and Engineering 2003 International Journal of CAD/CAM Vol.3 No.1
Disassembly is a fundamental process needed for component reuse and material recycling in all assembled products. Integral attachments, also known as 'snap' fits, are favored fastening means in design for assembly (DFA) methodologies, but not necessarily a favored choice for design for disassembly. In this paper, design methods of a new class of integral attachments are proposed, where the snapped joints can be disengaged by the application of localized heat sources. The design problem of reversible integral attachments is posed as the design of compliant mechanisms actuated with localized thermal expansion of materials. Topology optimization technique is utilized to obtain conceptual layout of snap-fit mechanisms that realizes a desired deformation of snapped features for joint release. Two design approaches are attempted and design results of each approach are presented, where the geometrical configuration extracted from optimal topologies are simplified to enhance the manufacturability for the conventional injection molding technologies. To maximize the magnitude of deformation, a design scheme has been proposed to include boundary conditions as design variables. Final designs are verified using commercial software for finite element analysis.