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만성적인 에탄올 섭취로 인한 쥐의 위 조직 손상에서 방사무늬 김( Pyropia yezoensis )의 보호효과
SaeidiSoma ( Saeidi Soma ),최정욱 ( Jeong Wook Choi ),이민경 ( Min Kyeong Lee ),김영민 ( Young Min Kim ),김인혜 ( In Hye Kim ),남택정 ( Taek Jeong Nam ) 한국수산과학회 2014 한국수산과학회지 Vol.47 No.6
We examined the protective effects of Pyropia yezoensis glycoprotein (PYGP) against ethanol-induced gastric damage. The experimental animals were divided into four groups. They were treated with distilled water (control), ethanol alone (EtOH), ethanol + PYGP 150 mg/kg BW (EtOH+150), or ethanol + PYGP 300 mg/kg BW (EtOH+300). The groups were treated for 4 weeks. We measured mitogen-activated protein kinase (MAPK), the apoptotic signaling pathway, and PARP activity in gastric tissues obtained from the rats. Ethanol consumption increased apoptotic signal activity and ERK, JNK, and p38 phosphorylation. PYGP reduced the apoptotic signaling pathway activity and ERK, JNK, and p38 phosphorylation. Furthermore, PYGP regulated Bcl-2 family expression. In light of these findings, PYGP appears to prevent ethanol-induced gastric injury and oxidative stress.