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An immunohistochemical Study on the Pancreatic Endocrine Cells of the C57Bl/6 Mouse
Hyeung-Sik Lee,Hyeung-SikLee,Sae-KywangKu 대한수의학회 2002 Journal of Veterinary Science Vol.3 No.4
The regional distribution and relative frequency ofthe pancreatic endocrine cells in the C57BL/6 mousewere studied by immunohistochemical method usingfour types of specific mammalian antisera againstinsulin,glucagon,somatostatin and human pancreaticpolypeptide (PP). The pancreas of mouse could bedivided into three portions;pancreatic islets, pancreaticduct and exocrine portions, and pancreatic isletswere further subdivided into three regions (central,mantle and peripheral regions) according to theirlocated types of immunoreactive cells and pancreaticduct portions were also subdivided into two regions(epithelial and connective tissue regions). In thepancreatic islet portions, although some cells werealso demonstrated in the mantle regions, most ofinsulin-immunoreactive cells were located in thecentral regions and they were randomly dispersed inthe whole pancreatic islets.Glucagon-immunoreactivecells were detected in the mantle and peripheralregions. Their relative frequencies in the peripheralregions were somewhat numerous than those of themantle regions. Somatostatin-immunoreactive cellswere detected in the mantle and peripheral regions.However,no PP-immunoreactive cells were demonstratedin the pancreatic islets of C57BL/6 mouse. In thepancreatic duct portions,rare glucagon-immunoreactivecells were situated in the epithelial regions. Cellclusters that consisted of glucagon- or somatostatin-immunoreactive cells were found in some case ofconnective tissue regions of pancreatic ducts.However,insulin-and PP-immunoreactive cells were not detectedin the epithelial nor connective tissue regions.In theexocrine portions, all four types of immunoreactivecells except for PP cells were demonstrated in the*Corresponding author: Hyeung-Sik Lee