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RISS 인기검색어
- 검색키워드
- 저자 : Sabuncu, Mustafa (검색결과 5 건)
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Gas-stabilizing nanoparticles for ultrasound imaging and therapy of cancer
Sabuncu Sinan,Yildirim Adem 나노기술연구협의회 2021 Nano Convergence Vol.8 No.39
The use of ultrasound in the clinic has been long established for cancer detection and image-guided tissue biopsies. In addition, ultrasound-based methods have been widely explored to develop more effective cancer therapies such as localized drug delivery, sonodynamic therapy, and focused ultrasound surgery. Stabilized fluorocarbon microbubbles have been in use as contrast agents for ultrasound imaging in the clinic for several decades. It is also known that microbubble cavitation could generate thermal, mechanical, and chemical effects in the tissue to improve ultrasound-based therapies. However, the large size, poor stability, and short-term cavitation activity of microbubbles limit their applications in cancer imaging and therapy. This review will focus on an alternative type of ultrasound responsive material; gas-stabilizing nanoparticles, which can address the limitations of microbubbles with their nanoscale size, robustness, and high cavitation activity. This review will be of interest to researchers who wish to explore new agents to develop improved methods for molecular ultrasound imaging and therapy of cancer.
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Static and dynamic stability of cracked multi-storey steel frames
Mustafa Sabuncu,Hasan Ozturk,Ahmed Yashar 국제구조공학회 2016 Structural Engineering and Mechanics, An Int'l Jou Vol.58 No.1
Multi-storey frame structures are frequently exposed to static and dynamic forces. Therefore analyses of static (buckling) and dynamic stability come into prominence for these structures. In this study, the effects of number of storey, static and dynamic load parameters, crack depth and crack location on the in-plane static and dynamic stability of cracked multi-storey frame structures subjected to periodic loading have been investigated numerically by using the Finite Element Method. A crack element based on the Euler beam theory is developed by using the principles of fracture mechanics. The equation of motion for the cracked multi-storey frame subjected to periodic loading is achieved by Lagrange’s equation. The results obtained from the stability analysis are presented in three dimensional graphs and tables.
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Vibration analysis of cracked frame structures
Ibrahim, Ahmed M.,Ozturk, Hasan,Sabuncu, Mustafa Techno-Press 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.45 No.1
In this study, the effects of crack depth and crack location on the in-plane free vibration of cracked frame structures have been investigated numerically by using the Finite Element Method. For the rectangular cross-section beam, a crack element is developed by using the principles of fracture mechanics. The effects of crack depth and location on the natural frequency of multi-bay and multi-store frame structures are presented in 3D graphs. The comparison between the present work and the results obtained from ANSYS shows a very good agreement.
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Vibration analysis of cracked frame structures
Ahmed M. Ibrahim,Hasan Ozturk,Mustafa Sabuncu 국제구조공학회 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.45 No.1
In this study, the effects of crack depth and crack location on the in-plane free vibration of cracked frame structures have been investigated numerically by using the Finite Element Method. For the rectangular cross-section beam, a crack element is developed by using the principles of fracture mechanics. The effects of crack depth and location on the natural frequency of multi-bay and multi-store frame structures are presented in 3D graphs. The comparison between the present work and the results obtained from ANSYS shows a very good agreement.
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Associations of serum fetuin-A and oxidative stress parameters with polycystic ovary syndrome
Sak, Sibel,Uyanikoglu, Hacer,Incebiyik, Adnan,Incebiyik, Hatice,Hilali, Nese Gul,Sabuncu, Tevfik,Sak, Erdal The Korean Society for Reproductive Medicine 2018 Clinical and Experimental Reproductive Medicine Vol.45 No.3
Objective: The aim of this study was to compare serum fetuin-A levels and oxidative stress markers, as indicators of insulin resistance, in women with polycystic ovary syndrome (PCOS) and in healthy controls. Methods: This prospective case-control study included 46 patients with PCOS and 48 age- and body mass index-matched control women. Levels of serum hormones, fetuin-A, and oxidative stress markers were measured in blood samples taken during the early follicular period from each participant. Results: Follicle-stimulating hormone (FSH), luteinising hormone (LH), total testosterone levels, and the LH/FSH ratio were found to be significantly higher in women with PCOS than in controls. Serum total antioxidant status, total oxidant status, and oxidative stress index parameters all indicated significantly higher levels of oxidative stress in PCOS patients than in controls. Serum fetuin-A levels, which were analyzed as an indicator of insulin resistance, were higher in the PCOS group than in the control group ($210.26{\pm}65.06{\mu}g/mL$ and $182.68{\pm}51.20{\mu}g/mL$, respectively; p= 0.024). Conclusion: The data obtained from the present study suggest that higher levels of both serum fetuin-A and oxidative stress markers might be related with PCOS.
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