국산박류의 사료가치에 관한 연구 2 . 부로일러에 대한 박류비교시험

백인기,한인규,김춘수 ( In K . Paik,In K . Han,Chun S . Kim ) 한국축산학회 1975 한국축산학회지 Vol.17 No.4

An experiment was conducted to study the comparative feeding value of locally produced vegetable protein cakes such as soybean oil meal (44%) (S.B.O.M.), rapeseed oil meal (R.O.M.), perilla oil meal (P.O.M.), sesame oil meal (S.O.M.) and corn gluten (50%). Three hundred broiler chickens were used for 8 weeks feeding trial and successive metabolic tiral. Results obtained are as follows; 1. Weight gains were significantly (P$lt;0.01) different among treatments showing the best gain in S.B.O.M. group and then P.O.M., R.O.M., corn gluten and S.O.M. group in that order. Feed intake showed same trend as weight gain did. For the feed efficiency, S.B.O.M. group was significantly (P$lt;0.01) superior to the other groups and S.O.M. group was significantly inferior to the other groups. Among the groups of receiving R.O.M., P.O.M. and corn gluten, differences were not significant each other in feed efficiency. 2. Amino acids compositions of R.O.M. and S.B.O.M. were better than that of other protein feeds considering their relatively high E.A.A. Index of 76.32 and 76.21 respectively. P.O.M., S.O.M. and corn gluten were low in lysine content while methionine contents were relatively high. 3. Nitrogen corrected M.E. values of S.B.O.M., R.O.M., P.O.M., S.O.M. and corn gluten were 2,367㎉, 843㎉, 2.234㎉, 1,305㎉ and 4,283㎉, respectively. Rates of nitrogen retention of P.O.M., S.B.O.M., R.O.M., corn gluten and S.O.M. were 59.38%, 51.18%, 54.11%, 44.80%, and 36.01%, respectively. 4. Dry matter and crude protein availabilities of finisher diet of R.O.M. group and S.B.O.M. group were higher than that of other groups but not significantly different. On the contrary however, crude fat availabilities of R.O.M., and S.B.O.M. group were significantly (P$lt;0.01) lower than that of other groups. 5. Thyroid gland weights and total serum cholesterol contents were significantly (P$lt;0.05) different among treatments. However, the relationship between thyroid gland weight and cholesterol content was observed only in R.O.M. group. Corn gluten was verb effective to increase skin pigmentation. 6. Production cost for 1㎏ of broiler meat of S.B.O.M. group was lower by about 20 won to 30won than that of R.O.M., corn gluten, or P.O.M. group, and by about 100won than that of sesame oil meal group which was least for the performance among the treatments.

Sources, distribution, bioavailability, toxicity, and risk assessment of heavy metal(loid)s in complementary medicines

Bolan, Shiv,Kunhikrishnan, Anitha,Seshadri, Balaji,Choppala, Girish,Naidu, Ravi,Bolan, Nanthi S.,Ok, Yong Sik,Zhang, Ming,Li, Chun-Guang,Li, Feng,Noller, Barry,Kirkham, Mary Beth Elsevier 2017 Environment international Vol.108 No.-

<P><B>Abstract</B></P> <P>The last few decades have seen the rise of alternative medical approaches including the use of herbal supplements, natural products, and traditional medicines, which are collectively known as ‘Complementary medicines’. However, there are increasing concerns on the safety and health benefits of these medicines. One of the main hazards with the use of complementary medicines is the presence of heavy metal(loid)s such as arsenic (As), cadmium (Cd), lead (Pb), and mercury (Hg). This review deals with the characteristics of complementary medicines in terms of heavy metal(loid)s sources, distribution, bioavailability, toxicity, and human risk assessment. The heavy metal(loid)s in these medicines are derived from uptake by medicinal plants, cross-contamination during processing, and therapeutic input of metal(loid)s. This paper discusses the distribution of heavy metal(loid)s in these medicines, in terms of their nature, concentration, and speciation. The importance of determining bioavailability towards human health risk assessment was emphasized by the need to estimate daily intake of heavy metal(loid)s in complementary medicines. The review ends with selected case studies of heavy metal(loid) toxicity from complementary medicines with specific reference to As, Cd, Pb, and Hg. The future research opportunities mentioned in the conclusion of review will help researchers to explore new avenues, methodologies, and approaches to the issue of heavy metal(loid)s in complementary medicines, thereby generating new regulations and proposing fresh approach towards safe use of these medicines.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A first-time comprehensive overview on the health risk assessment of heavy metal(loid)s in complementary medicines </LI> <LI> Ayurvedic medicines contain toxic levels of heavy metal(loid)s including As, Cd, Hg and Pb </LI> <LI> The bioavailability of metal(loid)s in complementary medicines depends on speciation of these metals </LI> <LI> Regular intake of some complementary medicines has caused metal(loid) toxicity in humans </LI> <LI> Health risk assessment can be achieved based on the daily intake of complementary medicines and total metal(loid) content </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Interactions between heavy metal(loid)s and complementary medicines.</P> <P>[DISPLAY OMISSION]</P>

Prurigo Pigmentosa: A Report of 5 Cases with a Review of the Korean Literature

Chun, Y. S Korean Dermatological Association 1998 Annals of Dermatology Vol.10 No.2

Purification and characterization of a novel fibrinolytic α chymotrypsin like serine metalloprotease from the edible mushroom, Lyophyllum shimeji

Moon, S.M.,Kim, J.S.,Kim, H.J.,Choi, M.S.,Park, B.R.,Kim, S.G.,Ahn, H.,Chun, H.S.,Shin, Y.K.,Kim, J.J.,Kim, D.K.,Lee, S.Y.,Seo, Y.W.,Kim, Y.H.,Kim, C.S. Society for Bioscience and Bioengineering, Japan ; 2014 Journal of bioscience and bioengineering Vol.117 No.5

A novel fibrinolytic enzyme was purified from Lyophyllum shimeji, a popular edible mushroom in Asia. The enzyme was purified using combination of anion exchange chromatography on a Mono Q 5/5 column and size exclusion gel filtration chromatography on Superdex 200 100/300 column. This purification protocol resulted 80.9-fold purification of the enzyme and a final yield of 5.7%. The molecular weight of the purified enzyme was estimated to be 21 kDa by SDS-PAGE and size exclusion gel filtration. The N-terminal amino acid sequence was found to be ITFQSASP, which is dissimilar from that of known fibrinolytic enzymes. The purified enzyme was a neutral protease with an optimal reaction pH and temperature of 8.0 and 37<SUP>o</SUP>C, respectively. Enzymatic activity was inhibited by Cu<SUP>2+</SUP> and Co<SUP>2+</SUP>. It was also significantly inhibited by PMSF and TPCK. Furthermore, it was found to exhibit a higher specificity for S-7388, a well-known chymotrypsin chromogenic substrate, indicating chymotrypsin like serine metalloprotease. The relative fibrinolytic activity of 5 μg purified enzyme have two fold more activity than 1 unit/ml of plasmin on fibrin plate. Furthermore, purified enzyme preferentially hydrolyzed the Aα-chain followed by the Bβ- and γ-chain of fibrinogen, which is precursor of fibrin. Therefore, these data suggests that the fibrinolytic enzyme derived from edible mushroom, L. shimeji, might be useful for thrombolytic therapy and preventing thrombotic disease.

Biochemical analysis of recombinant CYP4A11 allelic variant enzymes: W126R, K276T and S353G

Han, S.,Cha, G.S.,Chun, Y.J.,Lee, C.H.,Kim, D.,Yun, C.H. JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS 2016 DRUG METABOLISM AND PHARMACOKINETICS Vol.31 No.6

Human CYP4A11 is the major ω-hydroxylase of fatty acids in the liver and kidneys. It produces 20-hydroxyeicosatetraenoic acid as well as hydroxylates fatty acids. In this study, we investigated the biochemical properties of three alleles of CYP4A11: W126R, K276T, and S353G. Site-directed mutagenesis of the wild type CYP4A11 was performed, to construct the W126R, K276T, and S353G variant clones. The CYP4A11 wild type and variant constructs were heterologously expressed in Escherichia coli. CO-binding spectra showed the expression of the wild type, K276T and S353G variants, indicating the functional P450 holoenzyme. The W126R variant was not expressed in E. coli. Binding affinities of lauric acid in K276T and S353G variants were stronger than that of wild type. Steady-state kinetics in the hydroxylation reaction of fatty acids were studied. The catalytic efficiencies (k<SUB>cat</SUB>/K<SUB>m</SUB>) of K276T and S353G variants in the reactions without cytochrome b<SUB>5</SUB> were approximately 2- and 4-fold higher, respectively, than that of wild type, and in the reactions with cytochrome b<SUB>5</SUB> they were approximately 2- and 3-fold higher, respectively. These results suggest that individuals carrying the alleles, K276T and S353G, might exhibit higher catalysis of CYP4A11, which may affect the endogenous metabolic products associated with regulation of blood pressure.

Movement-Related Sensorimotor High-Gamma Activity Mainly Represents Somatosensory Feedback

Ryun, Seokyun,Kim, June S.,Jeon, Eunjeong,Chung, Chun K. Frontiers Media S.A. 2017 Frontiers in neuroscience Vol.11 No.-

<P>Somatosensation plays pivotal roles in the everyday motor control of humans. During active movement, there exists a prominent high-gamma (HG >50 Hz) power increase in the primary somatosensory cortex (S1), and this provides an important feature in relation to the decoding of movement in a brain-machine interface (BMI). However, one concern of BMI researchers is the inflation of the decoding performance due to the activation of somatosensory feedback, which is not elicited in patients who have lost their sensorimotor function. In fact, it is unclear as to how much the HG component activated in S1 contributes to the overall sensorimotor HG power during voluntary movement. With regard to other functional roles of HG in S1, recent findings have reported that these HG power levels increase before the onset of actual movement, which implies neural activation for top-down movement preparation or sensorimotor interaction, i.e., an efference copy. These results are promising for BMI applications but remain inconclusive. Here, we found using electrocorticography (ECoG) from eight patients that HG activation in S1 is stronger and more informative than it is in the primary motor cortex (M1) regardless of the type of movement. We also demonstrate by means of electromyography (EMG) that the onset timing of the HG power in S1 is later (49 ms) than that of the actual movement. Interestingly, we show that the HG power fluctuations in S1 are closely related to subtle muscle contractions, even during the pre-movement period. These results suggest the following: (1) movement-related HG activity in S1 strongly affects the overall sensorimotor HG power, and (2) HG activity in S1 during voluntary movement mainly represents cortical neural processing for somatosensory feedback.</P>

급속응고한 고망간 합금강 박판의 미세조직 및 기계적 성질에 미치는 V 첨가원소 및 열처리 영향

김형수,조성석,최창범,천병선 대한금속재료학회(대한금속학회) 1990 대한금속·재료학회지 Vol.28 No.2

We have investigated the effects of the microstructure and mechanical properties with V content and heat treatment on the rapidly solidified V added Fe-13 Mn-1.2C steel strips which were produced by a twin roll melt-quenching method. Regardless of the V content, solidification process typically took place by primary austenite formation and then the residual liquid phase formed austenite by massive transformation. In melt-quenched, the austenite to ferrite transformation was suppressed, resulting in only austenite. As the V content increased, the equiaxed structure region increased and the secondary dendrite arm spacing became a little wider. With the increase in V content, the refining of austenite grain size after heat treatment was accelerated because the increase in the formation of carbides suppressed the grain growth. As 0.2%Y.S. was increased with increasing V content, a relation between it and grain size as a function of V content can be expressed as the following equation. 0.2% Y.S.(㎏/㎟)=22.05+7.4/√D The mechanism of the large strengthening effect of V on the 0.2% Y.S. was considered to be attributable to the grain refining by V addition and the large increase of Petch constan

부신피질의 선종 및 암종이 병발한 Cushing 氏 症候群에 대하여

이창화,전영균,이종,최숙희,백태일,김영건,최정학,박춘식,배진선 대한적십자사 1976 적십자병원지 Vol.3 No.1

Sweet's Syndrome Associated with Acute Erythema Nodosum

Chang, S. N Korean Dermatological Association 1998 Annals of Dermatology Vol.10 No.3

Bentazon에 의한 畓多年生 雜草의 防除

全載哲,梁桓承,金成朝 圓光大學校 1978 論文集 Vol.12 No.-

Bentazon의 效果的인 使用方法을 究明하기 위하여 濟型, 使用時期, 湛水 및 落水條件등으로 나누어 單用, 組合 및 混合處理하여 實驗을 實施하였다. 1. Bentazon 液濟處理는 ?濟處理보다 높은 除草效果를 나타내었다. 2. Bentazon ?濟의 경우 모내기 25日後 處理보다는 15日後 處理에 있어서 效果가 높았다. 3. Bentazon은 湛水下 처리보다는 落水下 處理가 效果的이다. 4. Bentazon 單濟 1回 處理만으로는 피를 비롯한 一年生鏶草의 一部를 防除할 수 없으므로 avirosan 4.4/1.1G, 3kg/10a를 모내기 10日後에 處理하고 뒤이어 모내기 25日後에 bentazon 48%液濟 300cc/10a 處理나 10G 3kg/10a를 處理함이 가장 效果的이다. To establisy the effective application methods of bentazon (3-isopropyl-2, 1, 3-benzothiadiazin-4-one-2, 2-dioxide) for perennial weed control in paddy rice, the field experiment was conducted at different formulations, application dates, and flooded and drainage conditions according to treatments of bentazon alon and/or combination and incorporation with other chemicals. 1. Treatment of bentazon solution was more effective for weed control than that of bentazon granule. 2. In the case of bentazon granule, 15 days after transplanting(DAT) treatment showed better weeding effect than 25DAT treatment. 3. Weeding effect of bentazon treated under the flooed condition was less than under the drainage condition. 4. As a few annuals including barnyardgrass(Echinochloa crusgalli Beauv.) cannot be controlled by a single treatment of bentazon G, 10DAT treatment of avirosan(S-(2-methyl-1, 1-piperyl-carbonyl-methyl)-O, O-di-n-propyltihio-phosphate+2-methylthio-4-ethylamino-6-(2,1-dimethyplropylamino)-s-triazne4.4/1.1 G at 3kg/10afollowed by 25DAT treatment of bentazon 48% solution at 300 cc/10a or 10G at 3kg/10a is recommended for controlling anual and perennial weeds.