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Ye Hyon Park,Se Hee Park,Ryeo Bin Lee,Hye-Yon Cho,Jung Bae Kang,Pong Rheem Jang,Min Sun Kyung 순천향대학교 순천향의학연구소 2018 Journal of Soonchunhyang Medical Science Vol.24 No.1
Objective: The purpose of this study was to compare clinical and surgical outcomes of robotic single-site hysterectomy (RSSH) and robot-assisted multiport hysterectomy (RH) in benign disease. Methods: We retrospectively reviewed the medical records of 38 women who underwent RSSH (N=12) or RH (N=26) for the treatment of benign uterine disease between June 2015 and November 2017. Results: There were no intergroup differences in parity, comorbidities, and number of previous abdominal surgery. Mean age was older (49.5±5.05 years vs. 44.4±3.54 years, P=0.001) and mean body mass index was higher (27.4±2.47 kg/m2 vs. 25.3±3.12 kg/ m2, P=0.045) in RSSH group than RH group. Surgical outcomes, including operative time (165.0 minutes vs. 159.2 minutes, P=0.727), estimated blood loss (115.8±33.15 mL vs. 108.1±56.42 mL, P=0.662), uterus weight (445.9±157.21 g vs. 374.5±197.91 g, P=0.291), postoperative hospital stay (5.4±0.51 days vs. 5.8±1.20 days, P=0.289), postoperative hemoglobin change in day 1 (1.8±0.89 g/dL vs. 1.4±1.53 g/dL, P=0.431) and day 3 (2.1±1.32 g/dL vs. 1.7±1.83 g/dL, P=0.601), and perioperative complications did not significantly differ between two groups. The use of additional analgesics after 6 hours, 24 hours, and 48 hours, and mean NRS score after 6 hours, 24 hours, and 48 hours were not significantly different between two groups. Conclusion: RSSH might be an effective and safe alternative to RH, even if in older and/or obese women with large uteri.
Shin, Soon Shik,Park, Dongmin,Lee, Hee Young,Hong, Yeonhee,Choi, Jeonghyun,Oh, Jaeho,Lee, Hyunghee,Lee, Hye Rim,Kim, Mi Ryeo,Shen, Zhi Bin,Cui, Hong Hua,Yoon, Michung Informa Healthcare 2012 Pharmaceutical biology Vol.50 No.4
<P><I>Context</I>: Since AMP-activated protein kinase (AMPK) activation in skeletal muscle of obese rodents stimulates fatty acid oxidation, it is reasonable to hypothesize that pharmacological activation of AMPK might be of therapeutic benefit in obesity.</P><P><I>Objective</I>: To investigate the effects of the traditional Korean anti-obesity drug GGEx18, a mixture of three herbs, <I>Laminaria japonica</I> Aresch (Laminariaceae), <I>Rheum palmatum</I> L. (Polygonaceae), and <I>Ephedra sinica</I> Stapf (Ephedraceae), on obesity and the involvement of AMPK in this process.</P><P><I>Materials and methods</I>: After high fat diet-induced obese mice were treated with GGEx18, we studied the effects of GGEx18 on body weight, fat mass, skeletal muscle lipid accumulation, and the expressions of AMPK, peroxisome proliferator-activated receptor &aacgr;郭 (PPARα), and PPARα target genes. The effects of GGEx18 and/or the AMPK inhibitor compound C on lipid accumulation and expression of the above genes were measured in C2C12 skeletal muscle cells.</P><P><I>Results:</I> Administration of GGEx18 to obese mice for 9 weeks significantly (<I>p</I> < 0.05) decreased body and adipose tissue weights compared with obese control mice (<I>p</I> < 0.05). Lipid accumulation in skeletal muscle was inhibited by GGEx18. GGEx18 significantly (<I>p</I> < 0.05) increased skeletal muscle mRNA levels of AMPKα1 and AMPKα2 as well as PPARα and its target genes. Consistent with the <I>in vivo</I> data, GGEx18 inhibited lipid accumulation, and similar activation of genes was observed in GGEx18-treated C2C12 cells. However, compound C inhibited these effects in C2C12 cells.</P><P><I>Discussion and conclusion:</I> These results suggest that GGEx18 improves obesity through skeletal muscle AMPK and AMPK-stimulated expression of PPARα and its target enzymes for fatty acid oxidation.</P>