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- 저자 : Ruihua Fang (검색결과 2 건)
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Ruihua Fang,Jian Li,Weiping Wen,Wei Sun,Rui Xu,Jianbo Shi,Liang Peng,Yinyan Lai,Fenghong Chen,Yihui Wen 대한이비인후과학회 2022 Clinical and Experimental Otorhinolaryngology Vol.15 No.4
Objectives. Despite the efficacy of surgical treatments, the high rate of recurrence in juvenile nasopharyngeal angiofibroma (JNA) after surgery remains an unresolved problem. The present study comprehensively analyzed the risk factors and characteristics of JNA recurrence, providing clinical guidance for reducing recurrence. Methods. A total of 123 patients who underwent surgery for JNA between 1997 and 2019 at a single hospital were analyzed retrospectively. Univariate and multivariate analyses were used to assess the clinical risk factors for the recurrence of JNA. The relapse-free survival and annual cumulative recurrence rates were analyzed for subgroups defined according to clinical parameters. Results. After screening, 78 of the 123 patients were included in the present study. The main risk factors associated with JNA recurrence included the year of diagnosis, tumor size, sphenoid bone invasion, Radkowski stage, surgical approach, and intraoperative bleeding. Importantly, the surgical approach and sphenoid bone invasion were independent prognostic factors affecting recurrence. Patients who underwent endoscopic surgery without sphenoid bone invasion exhibited longer relapse-free survival. In the present study, the overall cumulative recurrence rate of JNA was 38.7%, and recurrence occurred mainly in the first year after the initial surgery. Conclusion. Endoscopic surgery achieved better relapse-free survival in JNA patients, and patients with sphenoid bone invasion should be carefully explored to avoid residual JNA. The recurrence rate of JNA differed among subgroups defined based on clinical parameters and was highest in the first year after surgery. Computed tomography or magnetic resonance imaging, along with close follow-up, should be performed strictly within 1 year after the primary operation.
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Fang Sun,Hongwei Jiang,Ruihua Zhu,Dan Wang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.2
In this work, novel nanoparticles-aggregated CuO sphere-like clusters were successfully synthesized on indium tin oxide (ITO) glass through a facile two-step procedure consisting of the fabrication of Cu2O films directly grown on ITO surface by electrodeposition, and subsequent calcinations of Cu2O films leading to the formation of CuO films. The morphology and structure of as-synthesized samples were characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD). It was found that the size of nanoparticles constituting sphere-like clusters structure obtained at 200℃ is much smaller than that of obtained at other temperature, which can provide large surface area for catalytic reaction. The CuO/ITO electrode was applied to detect glucose by cyclic voltammetry (CV) and amperometric detection (i - t). It was found that the obtained CuO films modified ITO electrode exhibited a much higher electrocatalytic activity for the oxidation of glucose in an alkaline medium through heat treatment of 200℃. A favorable performance with a high sensitivity of 1841.5544 µA mM-1 cm-2 to glucose ranging from 1.0 x 10-6 M to 5.0 x 10-4 M, a low operating potential of 0.35V versus Ag/AgCl and a fast amperometric response (within 3 s) were achieved on such CuO/ITO electrode. It also showed outstanding long-term stability and good reproducibility. Notably, poisoning by chloride ions and interference from ascorbic acid, uric acid and acetaminophen were negligible. Therefore, the nanoparticles-aggregated CuO sphere-like clusters would be a promising candidate electrode material for the development of nonenzymatic glucose sensors.
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