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Genetic screening in young women diagnosed with endometrial cancer
Basilio Pecorino,Cinzia Rubino,Vito Fabio Guardalà,Antonio Galia,Paolo Scollo 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.1
Objective: To evaluate the importance of Lynch syndrome associated risk screening in the patients aged less than 50 years affected from endometrial cancer. Methods: From 2007 to 2014, 41 patients affected from endometrial cancer and aged less than 50 years underwent surgery at the Complex Operative Unit of Gynecology and Obstetrics, Cannizzaro Hospital of Catania, Italy. They were selected to undergo mismatch repair gene mutation analysis using immunohistochemistry (IHC; four markers: MLH1, MSH2, MSH6, PMS2) and microsatellite instability (MSI) test. For samples that resulted negative to IHC (abnormal finding), MSI test was performed to further study the suspected mutation. Samples were classified as MSI-high (MSI-H) if more than one marker was identified as unstable; MSI-low (MSI-L) if only one marker was identified as unstable; or MSI-stable (MSI-S) if no marker was identified as unstable. Samples were subdivided into two groups: MSI-H/L and MSI-S. Statistical analysis was performed to assess differences regarding survival, tumor staging, grading, and invasion of lymphovascular space between these two groups. Results: IHC analysis showed that in 46% (19/41) of samples there was negative outcome. Forty-two percent (8/19) of these negative samples were unstable (either low or high). Of eight patients showing MSI, 75% were MSI-L, while 25% were MSI-H. Differences in survival, stage, grade, lymphovascular space invasion and Amsterdam criteria adherence were not statistically significant due to the small size of the cohort. Conclusion: IHC and MSI test results of our cohort lead us to assess the relevance of performing Lynch syndrome genetic screening in endometrial cancer patients aged less than 50 years at the time of diagnosis.
Verdura Vincenzo,Guastafierro Antonio,Di Pace Bruno,Faenza Mario,Nicoletti Giovanni Francesco,Rubino Corrado 대한성형외과학회 2022 Archives of Plastic Surgery Vol.49 No.1
Background Many authors have researched ways to optimize fat grafting by looking for a technique that offers safe and long-term fat survival rate. To date, there is no standardized protocol. We designed a “hydraulic system technique” optimizing the relationship among the quantity of injected fat, operative time, and material cost to establish fat volume cutoffs for a single procedure.Methods Thirty-six patients underwent fat grafting surgery and were organized into three groups according to material used: standard, “1-track,” and “2-tracks” systems. The amount of harvested and grafted fat as well as material used for each procedure was collected. Operating times were recorded and statistical analysis was performed to establish the relationship with the amount of treated fat.Results In 15 cases the standard system was used (mean treated fat 72 [30–100] mL, mean cost 4.23 ± 0.27 euros), in 11 cases the “1-track” system (mean treated fat 183.3 [120–280] mL, mean cost 7.63 ± 0.6 euros), and in 10 cases the “2-tracks” one (mean treated fat 311[220–550] mL, mean cost 12.47 ± 1 euros). The mean time difference between the standard system and the “1-track” system is statistically significant starting from three fat syringes (90 mL) in 17.66 versus 6.87 minutes. The difference between the “1-track” system and “2-tracks” system becomes statistically significant from 240 mL of fat in 15 minutes (“1-track”) versus 9.3 minutes for the “2-tracks” system.Conclusion Data analysis would indicate the use of the standard system, “1-track,” and “2-tracks” to treat an amount of fat < 90 mL of fat, 90 ÷ 240 mL of fat, and ≥ 240 mL of fat, respectively.
Verdura Vincenzo,Guastafierro Antonio,Di Pace Bruno,Faenza Mario,Nicoletti Giovanni Francesco,Rubino Corrado 대한성형외과학회 2022 Archives of Plastic Surgery Vol.49 No.2
Background Many authors have researched ways to optimize fat grafting by looking for a technique that offers safe and long-term fat survival rate. To date, there is no standardized protocol. We designed a “hydraulic system technique” optimizing the relationship among the quantity of injected fat, operative time, and material cost to establish fat volume cutoffs for a single procedure.Methods Thirty-six patients underwent fat grafting surgery and were organized into three groups according to material used: standard, “1-track,” and “2-tracks” systems. The amount of harvested and grafted fat as well as material used for each procedure was collected. Operating times were recorded and statistical analysis was performed to establish the relationship with the amount of treated fat.Results In 15 cases the standard system was used (mean treated fat 72 [30–100] mL, mean cost 4.23 ± 0.27 euros), in 11 cases the “1-track” system (mean treated fat 183.3 [120–280] mL, mean cost 7.63 ± 0.6 euros), and in 10 cases the “2-tracks” one (mean treated fat 311[220–550] mL, mean cost 12.47 ± 1 euros). The mean time difference between the standard system and the “1-track” system is statistically significant starting from three fat syringes (90 mL) in 17.66 versus 6.87 minutes. The difference between the “1-track” system and “2-tracks” system becomes statistically significant from 240 mL of fat in 15 minutes (“1-track”) versus 9.3 minutes for the “2-tracks” system.Conclusion Data analysis would indicate the use of the standard system, “1-track,” and “2-tracks” to treat an amount of fat < 90 mL of fat, 90 ÷ 240 mL of fat, and ≥ 240 mL of fat, respectively.
Flow recovery after posterior clinoidectomy for surgical clipping of anterior choroidal aneurysm
Federico Carlos Gallardo,Juan Santiago Bottan,Clara Martin,Aylen Andrea Targa Carcia,Roman Pablo Arevalo,Pablo Augusto Rubino 대한뇌혈관외과학회 2021 Journal of Cerebrovascular and Endovascular Neuros Vol.23 No.4
Inadvertent flow alterations in the parent artery during microsurgical clipping might produce postoperative ischemic complications. Intraoperative recognition of such alterations and its correction might improve operative outcomes in these patients. We present the case of a thirty-five-year-old male with an incidental small left anterior choroidal aneurysm. Microsurgical clipping induced an external compression of the anterior choroidal artery against the posterior clinoidal process which was identified in situ through surgical exploration and the loss of arterial doppler signal in the vessel. After failed attempts at clip repositioning, a posterior clinoidectomy was performed to decompress the artery. This resulted in arterial flow recovery. The aneurysm was successfully treated, and a severe ischemic complication was likely avoided. This intraoperative phenomenon has not yet been described in the literature.
Migration of α-tocopherol and resveratrol from poly(L-lactic acid)/starch blends films into ethanol
Hwang, S.W.,Shim, J.K.,Selke, S.,Soto-Valdez, H.,Matuana, L.,Rubino, M.,Auras, R. Applied Science Publishers 2013 Journal of food engineering Vol.116 No.4
Poly(L-lactic acid) (PLLA)/starch blends with various concentrations of two natural antioxidants, α-tocopherol (α-TOC) and resveratrol, were fabricated by a melt blending and compression molding processes. The effects of the two antioxidants on the optical (color), thermal and mechanical properties of PLLA/starch blends with antioxidants were assessed. PLLA/starch blend films with α-TOC and resveratrol showed a yellowish color influenced by the combined effect of white starch and the brown color of the antioxidants. The glass transition and melting temperatures were significantly reduced with the addition of antioxidants while enhanced thermal stability was observed, which could be a benefit and important for processing and production. The enhanced mechanical properties could be attributed to not only a compatibilization effect based on the chemical linkage between PLLA and starch chains, but also restriction of the chain mobility by antioxidants. The release of resveratrol from PLLA and PLLA/starch blend films into ethanol followed Fickian behavior. The D values of α-TOC were in the range of 0.47-3.95x10<SUP>-11</SUP>cm<SUP>2</SUP>s<SUP>-1</SUP> for PLLA films and 0.70-6.83x10<SUP>-11</SUP>cm<SUP>2</SUP>s<SUP>-1</SUP> for PLLA/starch blend films at 13<SUP>o</SUP>C, 5.67-13.0x10<SUP>-11</SUP>cm<SUP>2</SUP>s<SUP>-1</SUP> for PLLA films and 4.10-24.2x10<SUP>-11</SUP>cm<SUP>2</SUP>s<SUP>-1</SUP> for PLLA/starch blend films at 23<SUP>o</SUP>C, and 89.0-118.0x10<SUP>-11</SUP>cm<SUP>2</SUP>s<SUP>-1</SUP> for PLLA films and 123-282x10<SUP>-11</SUP>cm<SUP>2</SUP>s<SUP>-1</SUP> for PLLA/starch blend films at 43<SUP>o</SUP>C. The D values of resveratrol were in the range of 0.073-0.54x10<SUP>-10</SUP>cm<SUP>2</SUP>s<SUP>-1</SUP> for PLLA films and 1.42-6.93x10<SUP>-10</SUP>cm<SUP>2</SUP>s<SUP>-1</SUP> for PLLA/starch blend films at 13<SUP>o</SUP>C, 0.90-3.44x10<SUP>-10</SUP>cm<SUP>2</SUP>s<SUP>-1</SUP> for PLLA films and 4.16-22.3x10<SUP>-10</SUP>cm<SUP>2</SUP>s<SUP>-1</SUP> for PLLA/starch blend films at 23<SUP>o</SUP>C, and 24.8-74.1x10<SUP>-10</SUP>cm<SUP>2</SUP>s<SUP>-1</SUP> for PLLA films and 40.1-309x10<SUP>-10</SUP>cm<SUP>2</SUP>s<SUP>-1</SUP> for PLLA/starch blend films at 43<SUP>o</SUP>C.