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Targeting of epigenetic regulators in neuroblastoma
Luz Jubierre,Carlos Jiménez,Eric Rovira,Aroa Soriano,Constantino Sábado,Luis Gros,Anna Llort,Raquel Hladun,Josep Roma,Josep Sánchez de Toledo,Soledad Gallego,Miguel F. Segura 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Approximately 15,000 new cases of pediatric cancer are diagnosed yearly in Europe, with 8–10% corresponding to neuroblastoma, a rare disease with an incidence of 8–9 cases per million children <15 years of age. Although the survival rate for low-risk and intermediate-risk patients is excellent, half of children with high-risk, refractory, or relapsed tumors will be cured, and two-thirds of the other half will suffer major side effects and life-long disabilities. Epigenetic therapies aimed at reversing the oncogenic alterations in chromatin structure and function are an emerging alternative against aggressive tumors that are or will become resistant to conventional treatments. This approach proposes targeting epigenetic regulators, which are proteins that are involved in the creation, detection, and interpretation of epigenetic signals, such as methylation or histone post-translational modifications. In this review, we focused on the most promising epigenetic regulators for targeting and current drugs that have already reached clinical trials.
The erector spinae plane block: a narrative review
Pablo Kot,Pablo Rodriguez,Manuel Granell,Beatriz Cano,Lucas Rovira,Javier Morales,Ana Broseta,Jose De Andrés 대한마취통증의학회 2019 Korean Journal of Anesthesiology Vol.72 No.3
Regional anesthesia and pain management have experienced advances in recent years, especially with the advent of fascial plane blocks. The erector spinae plane block is one of the newest techniques to be described. In the past two years, publications referring to ESP block have increased significantly. The objective of this review is to analyze the articles about ESP block that have been published to date. We performed a search in the main databases and identified 368 articles. After a selection of the relevant articles, 125 studies were found eligible and were included in the review. The ESP block is performed by depositing the local anesthetic in the fascial plane, deeper than the erector spinae muscle at the tip of the transverse process of the vertebra. Many cases of its use have been described with satisfactory results in the treatment of both acute pain and chronic pain. The applicability of the technique covers many clinical scenarios. Of the 98 case reports reviewed, 12 and 87 articles, respectively described the technique as a treatment for chronic pain and acute pain. The single-shot was the most frequently used technique. As described in the articles published to date, the technique is easy to perform and has a low rate of complications. However, despite the effectiveness of the technique, further studies are necessary to obtain more evidence of its actions.
Sun, N.,Yun, J.,Liu, J.,Malide, D.,Liu, C.,Rovira, Ilsa I.,Holmstrom, Kira M.,Fergusson, Maria M.,Yoo, Y.,Combs, Christian A.,Finkel, T. Cell Press 2015 Molecular Cell Vol.60 No.4
Alterations in mitophagy have been increasingly linked to aging and age-related diseases. There are, however, no convenient methods to analyze mitophagy in vivo. Here, we describe a transgenic mouse model in which we expressed a mitochondrial-targeted form of the fluorescent reporter Keima (mt-Keima). Keima is a coral-derived protein that exhibits both pH-dependent excitation and resistance to lysosomal proteases. Comparison of a wide range of primary cells and tissues generated from the mt-Keima mouse revealed significant variations in basal mitophagy. In addition, we have employed the mt-Keima mice to analyze how mitophagy is altered by conditions including diet, oxygen availability, Huntingtin transgene expression, the absence of macroautophagy (ATG5 or ATG7 expression), an increase in mitochondrial mutational load, the presence of metastatic tumors, and normal aging. The ability to assess mitophagy under a host of varying environmental and genetic perturbations suggests that the mt-Keima mouse should be a valuable resource.
Singer, Oliver C.,Humpich, Marek C.,Fiehler, Jens,Albers, Gregory W.,Lansberg, Maarten G.,Kastrup, Andiras,Rovira, Alex,Liebeskind, David S.,Gass, Achim,Rosso, Charlotte,Derex, Laurent,Kim, Jong S.,Ne Wiley Subscription Services, Inc., A Wiley Company 2008 Annals of neurology Vol.63 No.1
<B>Objective</B><P>The risk for symptomatic intracerebral hemorrhage (sICH) associated with thrombolytic treatment has not been evaluated in large studies using diffusion-weighted imaging (DWI). Here, we investigated the relation between pretreatment DWI lesion size and the risk for sICH after thrombolysis.</P><B>Methods</B><P>In this retrospective multicenter study, prospectively collected data from 645 patients with anterior circulation stroke treated with intravenous or intraarterial thrombolysis within 6 hours (<3 hours: n = 320) after symptom onset were pooled. Patients were categorized according to the pretreatment DWI lesion size into three prespecified groups: small (≤10ml; n = 218), moderate (10–100ml; n = 371), and large (>100ml; n = 56) DWI lesions.</P><B>Results</B><P>In total, 44 (6.8%) patients experienced development of sICH. The sICH rate was significantly different between subgroups: 2.8, 7.8, and 16.1% in patients with small, moderate, and large DWI lesions, respectively (p < 0.05). This translates to a 5.8 (2.8)-fold greater sICH risk for patients with large DWI lesions as compared with patients with small (or moderate) DWI lesions. The results were similar in the large subgroup (n = 536) of patients treated with intravenous tissue plasminogen activator. DWI lesion size remained an independent risk factor when including National Institutes of Health Stroke Scale, age, time to thrombolysis, and leukoariosis in a logistic regression analysis.</P><B>Interpretation</B><P>This multicenter study provides estimates of sICH risk in potential candidates for thrombolysis. The sICH risk increases gradually with increasing DWI lesion size, indicating that the potential benefit of therapy needs to be balanced carefully against the risk for sICH, especially in patients with large DWI lesions. Ann Neurol 2007</P>
Cristol de Paiva Gouvˆea,F´abio Teixeira Dias,Valdemar das Neves Vieira,Douglas Langie da Silva,Jacob Schaf,Frederik Wolff-Fabris,Joan Josep Roa Rovira 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.10
In this work we report on systematic field-cooled magnetization experiments in melt-textured YBa2Cu3O7−δ samples containing Y211 precipitates. Magnetic fields up to 14 T were applied either parallel or perpendicular to the ab planes and a strong paramagnetic response related to the superconducting state was observed. This effect is known as paramagnetic Meissner effect (PME). The magnitude of the PME increases when the field is augmented. This effect shows a strong paramagnetic relaxation, such that the paramagnetic moment increases as a function of the time. The pinning by the Y211 particles plays a crucial role in the explanation of this effect and our results suggest that the pinning capacity can produce a strong flux compression into the sample,originating the PME and the strong time dependence.
Postthrombolysis hemorrhage risk is affected by stroke assessment bias between hemispheres
Audebert, H. J.,Singer, O. C.,Gotzler, B.,Vatankhah, B.,Boy, S.,Fiehler, J.,Lansberg, M. G.,Albers, G. W.,Kastrup, A.,Rovira, A.,Gass, A.,Rosso, C.,Derex, L.,Kim, J. S.,Heuschmann, P. Ovid Technologies (Wolters Kluwer) - American Acad 2011 Clinical Neurophysiology Vol.76 No.7