http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Rosnani Hasham,Hyun Kyung Choi,Mohamad Roji Sarmidi,박장서 한국생물공학회 2013 Biotechnology and Bioprocess Engineering Vol.18 No.1
Continuous exposure to ultraviolet (UV) irradiation leads to a variety of skin damage, such as sunburn,pigmentation, premature ageing, and photocarcinogenesis. Various phytochemical extracts have been identified to efficiently protect sun exposed skin from UV induced photodamage. A Ficus deltoidea (Mas cotek) water extract has been widely used for women’s health in Malaysia. In a previous study from this lab, the F. deltoidea extract exhibited strong anti-melanogenic effects towards cultured B16F1 melanoma cells. Additional studies were intended to evaluate the effects of the F. deltoidea extract on antiphotoageing activity using cultured human dermal fibroblasts and immortalised human keratinocytes (HaCaT). Both TNF-α and cyclooxygenase (COX-2) play primary roles in the inflammation process upon UV irradiation and are known to be stimulated by UVB irradiation. Treatment with the F. deltoidea extract dramatically inhibited the UVinduced TNF-α, IL-1α, IL-6, and COX-2 expression. The decreased collagen synthesis of fibroblasts as a result of UVB exposure was restored to a normal level after treatment with the F. deltoidea extract. In addition, the enhanced MMP-1 expression upon UVB irradiation was downregulated by the F. deltoidea extract in a dose-dependent manner. The overall findings indicate that the F. deltoidea extract may exert a protective effect against UVB-induced damage in the skin that is useful for anti-photoageing cosmetic products.
Potential Dermatological Application on Asian Plants
Nor Hazwani Mohd Ariffin,Rosnani Hasham 한국생물공학회 2016 Biotechnology and Bioprocess Engineering Vol.21 No.3
Skin diseases are among some of the most common types of health problems faced in Malaysia, as reported by the World Health Organization (WHO). Correspondingly, research into the use of medicinal plants for skin disease treatment has become important. Through the ages, medicinal plants have been used widely to treat a variety of skin diseases. The demand for plant-based medicines is growing, as they are generally considered to be safer and less harmful than conventional allopathic drugs. This article reviews the potential of Asian plants to be epidermal protecting agents. There are eleven remarkable Asian plants that are known for their skin barrier protecting agent properties. Important studies have shown that natural products offer a rich potential source of epidermal protecting agents. Nevertheless, further surveys and clinical evidence are needed to establish the potential of identified species in contributing to the treatment of skin disease, especially atopic eczema.
A long‐standing hyperglycaemic condition impairs skin barrier by accelerating skin ageing process
Park, Hwa‐,Young,Kim, Jae‐,Hong,Jung, Minyoung,Chung, Choon Hee,Hasham, Rosnani,Park, Chang Seo,Choi, Eung Ho Blackwell Publishing Ltd 2011 Experimental dermatology Vol.20 No.12
<P><B>Abstract: </B> Uncontrolled chronic hyperglycaemia including type 2 diabetes mellitus (DM) induces many skin problems related to chronic impaired skin barrier state. However, little is known about the skin barrier state of chronic hyperglycaemia patients, the dysfunction of which may be a major cause of their skin problems. In this study, we investigated whether a long‐standing hyperglycaemic condition including type 2 DM impairs skin barrier homoeostasis in proportion to the duration and its pathomechanism. We utilized the Otsuka Long‐Evans Tokushima Fatty (OLETF) rats as an animal model of long‐standing hyperglycaemia and Long‐Evans Tokushima Otsuka rats as a control strain. We confirmed that a long‐standing hyperglycaemia delayed skin barrier homoeostasis, which correlated with haemoglobin A1c levels. OLETF rats as a long‐standing hyperglycaemia model exhibited decreased epidermal lipid synthesis and antimicrobial peptide expression with increasing age. Decreased epidermal lipid synthesis accounted for decreased lamellar body production. In addition, OLETF rats had significantly higher serum levels of advanced glycation end products (AGEs) and elevated levels of the receptor for AGE in the epidermis. A long‐standing hyperglycaemic condition impairs skin barrier function including permeability and antimicrobial barriers by accelerating skin ageing process in proportion to the duration of hyperglycaemia, which could be a major pathophysiology underlying cutaneous complications of DM.</P>