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        Arterial Spin Labeling Magnetic Resonance Imaging in Healthy Adults: Mathematical Model Fitting to Assess Age-Related Perfusion Pattern

        Hu Ying,Liu Rongbo,Gao Fabao 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.7

        Objective: To investigate the age-dependent changes in regional cerebral blood flow (CBF) in healthy adults by fitting mathematical models to imaging data. Materials and Methods: In this prospective study, 90 healthy adults underwent pseudo-continuous arterial spin labeling imaging of the brain. Regional CBF values were extracted from the arterial spin labeling images of each subject. Multivariable regression with the Akaike information criterion, link test, and F test (Ramsey’s regression equation specification error test) was performed for 7 models in every brain region to determine the best mathematical model for fitting the relationship between CBF and age. Results: Of all 87 brain regions, 68 brain regions were best fitted by cubic models, 9 brain regions were best fitted by quadratic models, and 10 brain regions were best fitted by linear models. In most brain regions (global gray matter and the other 65 brain regions), CBF decreased nonlinearly with aging, and the rate of CBF reduction decreased with aging, gradually approaching 0 after approximately 60. CBF in some regions of the frontal, parietal, and occipital lobes increased nonlinearly with aging before age 30, approximately, and decreased nonlinearly with aging for the rest of life. Conclusion: In adults, the age-related perfusion patterns in most brain regions were best fitted by the cubic models, and age-dependent CBF changes were nonlinear.

      • Towards Instant Availability and Full Life Cycle Resilience in Vertical Cities: Automated Deployment and Transformation of High-Rise Buildings to Mitigate Social Challenges

        Thomas Bock,Rongbo Hu Council on Tall Building and Urban Habitat Korea 2022 International journal of high-rise buildings Vol.11 No.2

        High-rise buildings often can accommodate the population of small horizontal cities. The investment in high-rise buildings is considerable and therefore a rapid return on investment is necessary. The immediate availability of high-rise buildings can be achieved by automated prefabrication of highly finished modules and their instant on-site assembly by robotic and automated construction sites. A high-rise building as a vertical city can be considered as a sophisticated organism that can constantly change throughout its lifecycle in response to economic growth, demographic change, and environmental pressures. To date, many new urban high-rise developments claim to be "vertical cities", yet few represent this important characteristic. This article analyzed the technological readiness and innovations in the field of construction automation and robotics including single-task construction robots, automated on-site construction factories, and ambient assisted living. These technological advances enable the realization of future vertical cities that are able to continuously grow and transform in terms of form and function. Finally, the article proposes a visionary archetype of vertical city in the name of "dynamic vertical urbanism" that is easy to expand vertically and horizontally in order to achieve instant availability and full life cycle resilience thanks to advanced building technologies.

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