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RISS 인기검색어
- 검색키워드
- 저자 : Rong-hua Pan (검색결과 4 건)
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Rong-hua Pan,Feng-yan Xie,Hui-mei Chen,Li-zhi Xu,Xiao-chun Wu,Ling-ling Xu,Gang Yao 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.3
Salvianolic acid B (Sal B) is the most abundant bioactive molecule from Radix Salviae Miltiorrhizae, and has recently been used for treating renal fibrosis in traditional Chinese medicine. Here we investigated the ability reversal of Sal B to reverse the transdifferentiation of human kidney proximal tubular epithelial cells that was induced by transforming growth factor-beta 1 (TGF-β1). The effects of Sal B on HK-2 cell morphology were observed by phase contrast microscopy, while alpha smooth muscle actin and E-cadherin were studied by immunocytochemistry and real-time reverse transcription polymerase chain reaction, respectively. Exposure of HK-2 cells to TGF-β1 for 72 h induced a complete conversion of the epithelial cells to myofibroblasts. When HK-2 cells were co-incubated with Sal B and TGF-β1 for a further 72 h, the morphology of myofibroblasts returned to that of proximal tubular epithelial cells,whereas the myofibroblast phenotype was maintained after exposure of cells to TGF-β1 for 144 h. Sal B reduced alpha smooth muscle actin levels and increased E-cadherin levels compared with their epithelial-to-mesenchymal transition controls. The reversal effect of Sal B was dose-dependent. That Sal B reverses the epithelial-to-mesenchymal transition in vitro suggests that it could possibly facilitate the repair of tubular epithelial structures and the regression of renal fibrosis in injured kidneys.
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Viscoplastic response and collapse of 316L stainless steel tubes under cyclic bending
Kao-Hua Chang,Shane-Rong Sheu,Chien-Min Hsu,Wen-Fung Pan 국제구조공학회 2005 Steel and Composite Structures, An International J Vol.5 No.5
This paper presents the experimental and theoretical results of the viscoplastic response and collapse of 316L stainless steel tubes subjected to cyclic bending. The tube bending machine and curvatureovalization measurement apparatus, which was designed by Pan et al. (1998), were used for conducting the cyclic curvature-controlled experiment. Three different curvature-rates were controlled to highlight the characteristic of viscoplastic response and collapse. Next, the endochronic theory and the principle of virtual work were used to simulate the viscoplastic response of 316L stainless steel tubes under cyclic bending. In addition, a proposed theoretical formulation (Lee and Pan 2001) was used to simulate the relationship between the controlled cyclic curvature and the number of cycles to produce buckling under cyclic bending at different curvature-rates (viscoplastic collapse). It has been shown that the theoretical simulations of the response and collapse correlate well with the experimental data.
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Yi-Xin Pan,Hong-Bing Zhang,Rong-Hua Xie,Xing-Bin Liu,Min Wang 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.10
To characterize the effect of pipe inclination, low viscosity, flow rate and inlet water cut on annular flow pattern, a low viscosity oil-water two-phase annular flow in horizontal and slightly inclined (+1o, +3o and +5o) pipes with diameter of 20 mm has been experimentally investigated. A modified VOF model based on the CFD software package FLUENT was used to predict the in-situ oil fraction and pressure drop. The experimental data indicate that annular flow appears at a medium-high water cut. The slip ratio increases with flow rate increase but decreases with increasing water cut. The changes are more significant as the degree of inclination increases. Pressure drop is strongly dependent on flow rate, as it increases rapidly as inlet flow rate increase. Good agreement between the experimental data and calculated results of slip ratio and pressure drop was obtained.
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Wei Jiang,Jia-Jia Pan,Ying-Hui Deng,Mei-Rong Liang,Li-Hua Yao 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.6
Objective: MicroRNAs (miRNAs) play a vital role in pathogenesis and progression of many cancers, including cervical cancer. However, importance of serum level of miR-101 in cervical cancer has rarely been studied. In the present study, clinical significance and prognostic value of serum miR-101 for cervical cancer was investigated. Methods: Association between miR-101 level in cervical cancer tissues and prognosis of patients was analyzed by using data retrieved from The Cancer Genome Atlas (TCGA) database, which was followed with our clinical study in which miR-101 serum level comparison between cervical cancer patients and healthy controls was conducted by real-time quantitative polymerase chain reaction (PCR). Results: TCGA database demonstrated that miR-101 was down-regulated in cervical cancer tissues compared with normal cervical tissues, and univariate Cox regression analysis indicated that decreased miR-101 expression was a highly significant negative risk factor. Similar trend was found in the serum miR-101. Serum level of miR-101 was associated with International Federation of Gynecology and Obstetrics (FIGO) stage (p=0.003), lymph node metastasis (p=0.001), and serum squamous cell carcinoma antigen (SCC-Ag) level >4 (p=0.007). The overall survival time of cervical cancer patients with a higher level of serum miR-101 was significantly longer than that of patients with a lower level of serum miR-101. Moreover, multivariate Cox regression analysis indicated that the down-regulated serum level of miR-101 was an independent predictor for the unfavorable prognosis of cervical cancer. Conclusion: Serum level of miR-101 is closely associated with metastasis and prognosis of cervical cancer; and, hence could be a potential biomarker and prognostic predictor for cervical cancer.
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