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Novel time and site specific ‘‘tablets in capsule’’ system for nocturnal asthma treatment
Sonia Pandey,Preety Mehta,Hetal Patel,Ritesh Shah,Arti Gupta,Ashish Mishra 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.5
The objective of present work was to develop a‘‘tablets in capsule’’ system for facilitating both immediateand pulsatile drug deliveries of theophylline to mimic thecircadian rhythm of nocturnal asthma. The system comprisedof capsule filled with two tablets, first pulse andsecond pulse tablet prepared by wet granulation method. First pulse tablet was not coated and was responsible forproviding loading dose whereas; second pulse tablet wascoated with Eudragit L100 and Eudragit S100 to releasedrug in colon after specific lag time. Two independentvariables, amount of polymers and coating thickness, wereoptimized by 32 full factorial design. The optimum formulationconsisted of Eudragit L100: Eudragit S100 in1:1.5 ratio and coating thickness of 20 % (w/w). In vitrodrug release of ‘‘tablets in capsule’’ system in three differentmedia (pH 1.2, pH 6.8, and pH 7.4) revealedimmediate and pulsatile release patterns.