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RISS 인기검색어
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- 저자 : Preety Mehta (검색결과 2 건)
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Computation of design forces and deflection in skew-curved box-girder bridges
Preeti Agarwal,Priyaranjan Pal,Pradeep Kumar Mehta 국제구조공학회 2021 Structural Engineering and Mechanics, An Int'l Jou Vol.78 No.3
The analysis of simply supported single-cell skew-curved reinforced concrete (RC) box-girder bridges is carried out using a finite element based CsiBridge software. The behaviour of skew-curved box-girder bridges can not be anticipated simply by superimposing the individual effects of skewness and curvature, so it becomes important to examine the behaviour of such bridges considering the combined effects of skewness and curvature. A comprehensive parametric study is performed wherein the combined influence of the skew and curve angles is considered to determine the maximum bending moment, maximum shear force, maximum torsional moment and maximum vertical deflection of the bridge girders. The skew angle is varied from 0° to 60° at an interval of 10°, and the curve angle is varied from 0° to 60° at an interval of 12°. The scantly available literature on such bridges focuses mainly on the analysis of skew-curved bridges under dead and point loads. But, the effects of actual loadings may be different, thus, it is considered in the present study. It is found that the performance of these bridges having more curvature can be improved by introducing the skewness. Finally, several equations are deduced in the non-dimensional form for estimating the forces and deflection in the girders of simply supported skew-curved RC box-girder bridges, based upon the results of the straight one. The developed equations may be helpful to the designers in proportioning, analysing, and designing such bridges, as the correlation coefficient is about 0.99.
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Novel time and site specific ‘‘tablets in capsule’’ system for nocturnal asthma treatment
Sonia Pandey,Preety Mehta,Hetal Patel,Ritesh Shah,Arti Gupta,Ashish Mishra 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.5
The objective of present work was to develop a‘‘tablets in capsule’’ system for facilitating both immediateand pulsatile drug deliveries of theophylline to mimic thecircadian rhythm of nocturnal asthma. The system comprisedof capsule filled with two tablets, first pulse andsecond pulse tablet prepared by wet granulation method. First pulse tablet was not coated and was responsible forproviding loading dose whereas; second pulse tablet wascoated with Eudragit L100 and Eudragit S100 to releasedrug in colon after specific lag time. Two independentvariables, amount of polymers and coating thickness, wereoptimized by 32 full factorial design. The optimum formulationconsisted of Eudragit L100: Eudragit S100 in1:1.5 ratio and coating thickness of 20 % (w/w). In vitrodrug release of ‘‘tablets in capsule’’ system in three differentmedia (pH 1.2, pH 6.8, and pH 7.4) revealedimmediate and pulsatile release patterns.
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