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Sepsis-induced cardiac dysfunction: a review of pathophysiology
Habimana Reverien,최인수,조화진,김도완,이교선,정인석 대한중환자의학회 2020 Acute and Critical Care Vol.35 No.2
It is well known that cardiac dysfunction in sepsis is associated with significantly increased mortality. The pathophysiology of sepsis-induced cardiac dysfunction can be summarized as involving impaired myocardial circulation, direct myocardial depression, and mitochondrial dysfunction. Impaired blood flow to the myocardium is associated with microvascular dysfunction, impaired endothelium, and ventriculo-arterial uncoupling. The mechanisms behind direct myocardial depression consist of downregulation of β-adrenoceptors and several myocardial suppressants (such as cytokine and nitric oxide). Recent research has highlighted that mitochondrial dysfunction, which results in energy depletion, is a major factor in sepsis-induced cardiac dysfunction. Therefore, the authors summarize the pathophysiological process of cardiac dysfunction in sepsis based on the results of recent studies.
Extracorporeal circulation models in small animals: beyond the limits of preclinical research
Mukhammad Kayumov,Reverien Habimana,김도완,Francis O Obiweluozor,정인석,조화진 대한중환자의학회 2023 Acute and Critical Care Vol.38 No.1
Extracorporeal membrane oxygenation (ECMO) use has remarkably increased in recent years. Al- though ECMO has become essential for patients with refractory cardiac and respiratory failure, ex- tracorporeal circulation (ECC) is associated with significant complications. Small-animal models of ECC have been developed and widely used to better understand ECC-induced pathophysiology. This review article summarizes the development of small-animal ECC models, including the animal spe- cies, circuit configuration, priming, perioperative procedures, cannulation, and future perspectives of small-animal ECMO models.