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- 저자 : Renuka Prasad (검색결과 2 건)
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A concise review of human brain methylome during aging and neurodegenerative diseases
( Renuka Prasad G ),( Eek-hoon Jho ) 생화학분자생물학회 2019 BMB Reports Vol.52 No.10
DNA methylation at CpG sites is an essential epigenetic mark that regulates gene expression during mammalian development and diseases. Methylome refers to the entire set of methylation modifications present in the whole genome. Over the last several years, an increasing number of reports on brain DNA methylome reported the association between aberrant methylation and the abnormalities in the expression of critical genes known to have critical roles during aging and neurodegenerative diseases. Consequently, the role of methylation in understanding neurodegenerative diseases has been under focus. This review outlines the current knowledge of the human brain DNA methylomes during aging and neurodegenerative diseases. We describe the differentially methylated genes from fetal stage to old age and their biological functions. Additionally, we summarize the key aspects and methylated genes identified from brain methylome studies on neurodegenerative diseases. The brain methylome studies could provide a basis for studying the functional aspects of neurodegenerative diseases. [BMB Reports 2019; 52(10): 577-588]
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CRISPR/Cas9 assisted stem cell therapy in Parkinson's disease
Poojitha Pinjala,Kamatham Pushpa Tryphena,Renuka Prasad,Dharmendra Kumar Khatri,선웅,Shashi Bala Singh,Dalapathi Gugulothu,Saurabh Srivastava,Lalitkumar Vora 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Since its discovery in 2012, CRISPR Cas9 has been tried as a direct treatment approach to correct the causative gene mutation and establish animal models in neurodegenerative disorders. Since no strategy developed until now could completely cure Parkinson’s disease (PD), neuroscientists aspire to use gene editing technology, especially CRISPR/Cas9, to induce a permanent correction in genetic PD patients expressing mutated genes. Over the years, our understanding of stem cell biology has improved. Scientists have developed personalized cell therapy using CRISPR/Cas9 to edit embryonic and patient-derived stem cells ex-vivo. This review details the importance of CRISPR/Cas9-based stem cell therapy in Parkinson’s disease in developing PD disease models and developing therapeutic strategies after elucidating the possible pathophysiological mechanisms.
ScienceON
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