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        Antibacterial effect of biodegradable gelatin methacryloyl loaded with ginger rhizome extract

        Regina Guadalupe Arbizú-Trigueros,김서영,김유경,장용석,최애진,배태성,이민호 대한치과재료학회 2022 대한치과재료학회지 Vol.49 No.4

        Gelatin methacryloyl 3d mesh mimics the natural extracellular matrix which allow loading as promising drug delivery systems. However, insufficient mechanical and degradation properties remain the biggest obstacle for this material application. In thisstudy, a modified hydrogel with natural phytochemical was developed to improve the antibacterial effect by the additionof ginger extract, a natural spicy used in traditional medicine. GelMA hydrogels with ginger extract were fabricated and theirchemical and morphological characteristics were analyzed by Fourier transformer infrared spectroscopy and scanning electronmicroscopy, structural characteristic were evaluated by compressive test and surface wettability analysis. S. mutans, S. aureusand P. gingivalis were used to confirm the antibacterial effect of the modified hydrogels. The FT-IR spectra of the hydrogelsmodified with ginger presented an increase in intensity of some peaks in comparison with the 10% GelMA hydrogel. Thepores of ginger-modified hydrogels decreased it size which affected the hydrogels physical properties, decreasing the compressivemodulus and increasing the durability, swelling ratio and, hydrophobicity of the surface. The ginger-modified hydrogels exhibitedexcellent antibacterial properties against S. mutans and S. aureus at high concentrations of ginger extract, while P. gingivalispresented a higher sensitivity at all tested concentrations. Hence, this study concludes that ginger-modified GelMA hydrogelspresented better antibacterial effect, durability over time and, swelling stability.

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